Compare Strattera vs. Provigil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Strattera (Atomoxetine)

Prescription only

Provigil (modafinil)

Prescription only
Helps you focus and stay alert.

Strattera (Atomoxetine) isn't considered a first-line medication for ADHD, but since it isn't a stimulant, it's still highly recommended.

3.2/ 5 average rating with 94 reviewsforStrattera
Improves alertness.

Provigil (modafinil) is effective in improving alertness, but it interacts with some medicines and shouldn't be used long-term.

4.2/ 5 average rating with 28 reviewsforProvigil
Upsides
  • One of the few medications used to treat ADHD that's not a stimulant.
  • It isn't a controlled substance.
  • Strattera (Atomoxetine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • You usually only need to take it once a day.
  • Provigil (modafinil) is a nonstimulant medication that improves alertness.
  • Provigil (modafinil) is available in a cheaper, generic version.
  • Provigil (modafinil) is good at decreasing excessive sleepiness in shift work sleep disorder.
  • If you need to sleep in the daytime, this medication won't effect you.
Downsides
  • It's a second-line medication used to treat ADHD. Other medications are usually tried first.
  • It's only available as a brand name medication, so it can be expensive.
  • Provigil (modafinil) can be habit forming, so it shouldn't be used for long-term treatment.
  • Provigil (modafinil) is not a good choice if you have liver problems.
  • May not be a good option if you are taking hormonal contraception like birth control pills.
Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
94 reviews so far
46%
saidit'sworth it
32%
saiditworked well
24%
saidit'sa big hassle

Have you used Strattera (Atomoxetine)?

Leave a review
28 reviews so far
82%
saidit'sworth it
71%
saiditworked well
4%
saidit'sa big hassle

Have you used Provigil (modafinil)?

Leave a review
Side effects
30possible side effects
  • Nausea
    26%
  • Dry mouth
    20%
  • Decreased appetite
    16%
  • Insomnia
    15%
  • Changes in heart rate or blood pressure
    10%
  • Fatigue
    10%
  • Constipation
    8%
  • Dizziness
    8%
  • Somnolence
    8%
  • Erectile dysfunction
    8%
  • Abdominal pain
    7%
  • Urinary hesitation
    6%
  • Irritability
    5%
  • Dyspepsia
    4%
  • Vomiting
    4%
  • Abnormal dreams
    4%
  • Ejaculation delayed and/or ejaculation disorder
    4%
  • Hyperhidrosis
    4%
  • Palpitations
    3%
  • Chills
    3%
  • Paraesthesia
    3%
  • Libido decreased
    3%
  • Sleep disorder
    3%
  • Dysmenhorrhea
    3%
  • Hot flush
    3%
  • Feeling jittery
    2%
  • Thirst
    2%
  • Weight loss
    2%
  • Dysuria
    2%
  • Any sexual side effect
    2%
See more detailed side effects
25possible side effects
  • Headache
    34%
  • Nausea
    11%
  • Nervousness
    7%
  • Stuffy nose
    7%
  • Back pain
    6%
  • Diarrhea
    6%
  • Indigestion
    5%
  • Difficulty sleeping
    5%
  • Anxiety
    5%
  • Dizziness
    5%
  • Flu symptoms
    4%
  • Dry mouth
    4%
  • Loss of appetite
    4%
  • Throat inflammation
    4%
  • Chest pain
    3%
  • High blood pressure
    3%
  • Fast heart beat
    2%
  • Palpitation
    2%
  • Dilation of blood vessels
    2%
  • Constipation
    2%
  • Abnormal liver function
    2%
  • Depression
    2%
  • Burning/tingling sensation
    2%
  • Drowsiness
    2%
  • Lung disorder
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thinking
    • Age below 18
  • Liver disease
  • Serious or life-threatening cardiovascular events
    • History of heart problems
  • Aggressive behavior and psychosis
    • History of psychotic episodes
    • History of Bipolar Disorder
  • Prolonged erection
  • Problems with urination
  • Long-term growth suppression
    • Starting Strattera (Atomoxetine) before puberty
See more detailed risks and warnings
  • Serious allergic reactions
    • Allergy to Provigil (modafinil)
  • Heart problems
    • History of heart problems
  • Increased side effects
    • Current kidney problems
    • Current liver problems
  • Driving impairment
    • Taking with alcohol or drugs
See more detailed risks and warnings