Compare Strattera vs. Provigil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Strattera
(atomoxetine)

Provigil
(modafinil)

Helps you focus and stay alert. Strattera (Atomoxetine) isn't considered a first-line medication for ADHD, but since it isn't a stimulant, it's still highly recommended.Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.
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Coupons for Strattera
Best available price for 30 (40mg) tablets of strattera
Coupons for Provigil
Best available price for 30 (200mg) tablets of provigil
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.32Strattera
Reviews for Strattera
46%
of people (All ages) say Strattera is worth it
32%
say it works well
24%
say it's a big hassle
Have you used Strattera (atomoxetine)?
Worth itNot sureNot worth it
Reviews for Provigil
82%
-36% worse vs. Strattera
71%
-39% worse vs. Strattera
4%
-20% worse vs. Strattera
Have you used Provigil (modafinil)?
Worth itNot sureNot worth it
Side effects
StratteraProvigil
  • Headache 4%
  • Abdominal pain 8%
  • Decreased appetite 12%
  • Vomiting 5%
  • Drowsiness 7%
  • Changes in heart rate or blood pressure 10%
  • Nausea 5%
  • Fatigue 5%
  • Irritability 3%
  • Dizziness 3%
More Strattera side effects »
  • Headache 11%
  • Nausea 8%
  • Any side effect 5%
  • Inflammation inside the nose 1%
  • Nervousness 4%
  • Back pain 1%
  • Diarrhea 1%
  • Dizziness 1%
  • Sleep difficulty 4%
  • Indigestion 1%
More Provigil side effects »
How it works
StratteraProvigil
Strattera (Atomoxetine) is a norepinephrine reuptake inhibitor (non-stimulant). Researchers don't know exactly how it works for ADHD, but it increases norepinephrine activity in the brain, which affects attention and behavior.Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.
Type of medication
StratteraProvigil
Prescription onlyPrescription only
Available as
StratteraProvigil
  • Pill
  • Pill
Used for
StratteraProvigil
Risk factors for serious side effects
StratteraProvigil
  • Age below 18
  • History of heart problems
  • History of psychotic episodes
  • History of Bipolar Disorder
  • Starting Strattera (Atomoxetine) before puberty
Detailed Strattera (atomoxetine) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Current kidney problems
  • Current liver problems
  • History of heart problems
Detailed Provigil (modafinil) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
StratteraProvigil
No interactions related info.
  • Interacts with many other medications.
Alcohol
StratteraProvigil
No alcohol related info.
  • Don't drink alcohol with Provigil (Modafinil).
Kidneys and liver
StratteraProvigil
No kidneys and liver related info.
  • Not a good choice if you have liver or kidney problems.
  • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
Upsides and benefits
StratteraProvigil
  • One of the few medications used to treat ADHD that's not a stimulant.
  • It isn't a controlled substance.
  • Strattera (Atomoxetine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • You usually only need to take it once a day.
  • It's a non-amphetamine medicine that helps improve alertness.
  • Available in a generic version.
  • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
  • Doesn't negatively affect daytime sleep.
Downsides and risks
StratteraProvigil
  • It's a second-line medication used to treat ADHD. Other medications are usually tried first.
  • It's only available as a brand name medication, so it can be expensive.
  • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
  • Interacts with many other medications.
  • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
  • Not a good choice if you have liver or kidney problems.
Tips from our pharmacists for people taking the medication
StratteraProvigil
  • It can cause changes in sex drive.
  • Can raise your blood pressure and pulse, so it's not safe for people with heart problems.
  • It can also cause changes in your mood.
  • Take it at the same time every day.
  • Common side effects include decreased appetite, nausea, and constipation.
  • The capsules can't be opened and need to be swallowed whole.
  • Take Provigil (Modafinil) about an hour before you need to be fully alert.
  • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
  • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
  • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
  • Tell your doctor right away if you break out in a rash.
  • Don't drink alcohol with Provigil (Modafinil).
Learn more
More about StratteraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Strattera (atomoxetine)?
Worth itNot sureNot worth it
More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Provigil (modafinil)?
Worth itNot sureNot worth it