Compare Strattera vs. Vyvanse

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Strattera
(Atomoxetine)

Vyvanse
(Lisdexamfetamine)

Helps you focus and stay alert. Strattera (Atomoxetine) isn't considered a first-line medication for ADHD, but since it isn't a stimulant, it's still highly recommended.Helps you focus and stay alert. Vyvanse (Lisdexamfetamine) is a first-choice treatment for ADHD and you only have to take it once a day. However, it's only available as brand name drug, so it can be expensive.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.32Strattera
Reviews for Strattera (Atomoxetine)
46%
of people (All ages) say Strattera (Atomoxetine) is worth it
32%
say it works well
24%
say it's a big hassle
Have you used Strattera (Atomoxetine)?
Worth itNot sureNot worth it
Reviews for Vyvanse (Lisdexamfetamine)
67%
+21% vs. Strattera (Atomoxetine)
49%
+17% vs. Strattera (Atomoxetine)
17%
+7% vs. Strattera (Atomoxetine)
491 reviews
Have you used Vyvanse (Lisdexamfetamine)?
Worth itNot sureNot worth it
Side effects
StratteraVyvanse
  • Abdominal pain 11%
  • Nausea 9%
  • Fatigue 7%
  • Vomiting 3%
  • Constipation 1%
More Strattera side effects »

The Vyvanse FDA package insert doesn’t have numbers about how common side effects are.

More about Vyvanse side effects »
How it works
StratteraVyvanse
Strattera (Atomoxetine) is a norepinephrine reuptake inhibitor (non-stimulant). Researchers don't know exactly how it works for ADHD, but it increases norepinephrine activity in the brain, which affects attention and behavior.Vyvanse (Lisdexamfetamine) is an amphetamine stimulant. Researchers don't know exactly how it works for ADHD, but it increases norepinephrine and dopamine activity in the brain, which affects attention and behavior.
Type of medication
StratteraVyvanse
Selective norepinephrine reuptake inhibitor (SNRI)Prescription only
StimulantPrescription only
Available as
StratteraVyvanse
  • Pill
  • Pill
Used for (click to learn more)
StratteraVyvanse
Risk factors for serious side effects
StratteraVyvanse
  • Age below 18
  • History of heart problems
  • History of psychotic episodes
  • History of Bipolar Disorder
  • Starting Strattera (Atomoxetine) before puberty
Detailed risks & warnings »
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • History of drug abuse
  • History of heart problems
  • History of psychotic episodes
  • History of Bipolar Disorder
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
StratteraVyvanse
No alcohol related info.
  • Don't take it with alcohol or drugs.
Upsides and benefits
StratteraVyvanse
  • One of the few medications used to treat ADHD that's not a stimulant.
  • It isn't a controlled substance.
  • Strattera (Atomoxetine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • You usually only need to take it once a day.
  • First-choice medication to treat ADHD.
  • Vyvanse (Lisdexamfetamine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • Usually dosed once a day, so parents don't need to send the medication with their children to school.
  • The capsule can be taken whole, or opened into a glass of water or orange juice, or swallowed in a spoonful of yogurt.
Downsides and risks
StratteraVyvanse
  • It's a second-line medication used to treat ADHD. Other medications are usually tried first.
  • It's only available as a brand name medication, so it can be expensive.
  • Has to be taken in the morning, otherwise it can cause insomnia later that night.
  • Not available as a generic medication, so it can be expensive.
  • It's a controlled medication and should be locked up to prevent potential abuse.
  • Not safe for people with a history of heart problems.
Tips from our pharmacists for people taking the medication
StratteraVyvanse
  • It can cause changes in sex drive.
  • It can also cause changes in your mood.
  • Take it at the same time every day.
  • Common side effects include decreased appetite, nausea, and constipation.
  • The capsules can't be opened and need to be swallowed whole.
  • Can raise your blood pressure and pulse, so it's not safe for people with heart problems.
  • Take Vyvanse (Lisdexamfetamine) early in the morning to prevent insomnia later that night.
  • Avoid driving the first few days that you take Vyvanse (Lisdexamfetamine) until you know how your body reacts to it.
  • Don't take it with alcohol or drugs.
  • Store it in a locked area to prevent abuse.
  • It can cause changes in your mood.
  • Can raise your blood pressure and pulse, so it's not safe for people with heart problems.
Learn more
More about StratteraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Strattera (Atomoxetine)?
Worth itNot sureNot worth it
More about VyvanseSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vyvanse (Lisdexamfetamine)?
Worth itNot sureNot worth it