Compare Stribild vs. Complera

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Stribild
(elvitegravir / cobicistat / emtricitabine / tenofovir)

Complera
(emtricitabine / rilpivirine / tenofovir)

Treats HIV infection. Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) is a convenient 4-in-1 medication and one of the first choices used to treat HIV infections.Treats HIV infection Complera (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections.
Reviews & ratings
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Have you used Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir)?
Worth itNot sureNot worth it

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Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
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Side effects
StribildComplera
  • Nausea 16%
  • Diarrhea 12%
  • Abnormal dreams 9%
  • Headache 7%
  • Fatigue 4%
  • Rash 4%
  • Dizziness 3%
  • Insomnia 3%
  • Flatulence 2%
More Stribild side effects »
  • Headache 2%
  • Depressive disorders 2%
  • Insomnia 2%
More Complera side effects »
How it works
StribildComplera
Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) is a combination pill that contains four HIV drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Complera (emtricitabine / rilpivirine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.
Type of medication
StribildComplera
Prescription onlyPrescription only
Available as
StribildComplera
  • Pill
  • Pill
Used for
StribildComplera
Risk factors for serious side effects
StribildComplera
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of bone fractures
Detailed Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) risks & warnings »
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
Detailed Complera (emtricitabine / rilpivirine / tenofovir) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
StribildComplera
  • Can interact with many other drugs.
No interactions related info.
Food
StribildComplera
  • Take with food.
No food related info.
Kidneys and liver
StribildComplera
  • First-choice treatment for HIV in patients with good kidney function.
  • Can't be used in patients with kidney problems.
  • Complera (emtricitabine / rilpivirine / tenofovir) is not yet approved for treating Hepatitis B. If you have hepatitis B and HIV, don't stop taking Complera (emtricitabine / rilpivirine / tenofovir) without talking to your doctor since your hepatitis can get worse. Your doctor will check your liver regularly.
  • People on Complera (emtricitabine / rilpivirine / tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles. Your doctor will do blood tests to check your kidneys regularly while you're taking Complera (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients with kidney damage.
Upsides and benefits
StribildComplera
  • First-choice treatment for HIV in patients with good kidney function.
  • One tablet contains four different HIV medications.
  • Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) is only taken once daily.
  • There are assistance programs available through the manufacturer of Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) if you need help paying for high insurance copays.
  • Complera (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Complera (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
Downsides and risks
StribildComplera
  • Can't be used in patients with kidney problems.
  • Can interact with many other drugs.
  • Must be taken with a light meal which includes fat.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Complera (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Not recommended for patients with kidney damage.
  • Can weaken your bones.
Tips from our pharmacists for people taking the medication
StribildComplera
  • Take around the same time each day.
  • Take with food.
  • If you take antacids, separate it from Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) by at least two hours.
  • Talk to your doctor or pharmacist before starting any new medication while on Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) to prevent drug interactions.
  • Keep your regularly scheduled doctor's and lab appointments. These help ensure your medication is working well and safely.
  • Keep an eye out for any new symptoms or side effects you may start to feel while taking Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) and report them to your doctor.
  • Complera (emtricitabine / rilpivirine / tenofovir) should be taken at the same time everyday.
  • For missed doses, take one if you remember within 12 hours of your regularly scheduled time. Don't take two doses at the same time.
  • Take Complera (emtricitabine / rilpivirine / tenofovir) with at least a light meal with 12 grams of fat. Some examples that the makers of Complera (emtricitabine / rilpivirine / tenofovir) list are toast with peanut butter & fruit, roast beef sandwich, or a grilled chicken caesar salad.
  • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your doctor.
Learn more
More about StribildSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir)?
Worth itNot sureNot worth it
More about CompleraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Complera (emtricitabine / rilpivirine / tenofovir)?
Worth itNot sureNot worth it