Compare Stribild vs. Isentress

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Stribild
(elvitegravir / cobicistat / emtricitabine / tenofovir)

Isentress
(raltegravir)

Treats HIV infection. Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) is a convenient 4-in-1 medication and one of the first choices used to treat HIV infections.Works with other medicines to treat HIV infection. This is the first medication approved as an Integrase Inhibitor (InSTI), so it may be a great, but somewhat expensive, option for people who have already tried other drugs and need another option.
Reviews & ratings
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Have you used Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir)?
Worth itNot sureNot worth it

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Have you used Isentress (raltegravir)?
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Side effects
StribildIsentress
  • Nausea 16%
  • Diarrhea 12%
  • Abnormal dreams 9%
  • Headache 7%
  • Fatigue 4%
  • Rash 4%
  • Dizziness 3%
  • Sleep difficulty 3%
  • Passing gas 2%
More Stribild side effects »

We haven’t found good data for Isentress side effects.

FDA side effect reports for Isentress »
How it works
StribildIsentress
Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) is a combination pill that contains four HIV drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Isentress stops the replication of the human immunodeficiency virus (HIV) within important cells of the body by preventing the virus from taking over normal functions of the cell for its own purposes.
Type of medication
StribildIsentress
Prescription onlyPrescription only
Available as
StribildIsentress
  • Pill
  • Pill
  • Chewable tablet
  • Liquid
Used for
StribildIsentress
  • HIV Infection
Risk factors for serious side effects
StribildIsentress
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of bone fractures
Detailed Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) risks & warnings »
  • Prior severe allergic reaction to Isentress
  • Phenylketonuria
  • Certain drugs can increase the dose of Isentress in the body
  • HIV
Detailed Isentress (raltegravir) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
StribildIsentress
  • Can interact with many other drugs.
No interactions related info.
Food
StribildIsentress
  • Take with food.
  • Take Isentress with or without food.
Kidneys and liver
StribildIsentress
  • First-choice treatment for HIV in patients with good kidney function.
  • Can't be used in patients with kidney problems.
No kidneys and liver related info.
Pain
StribildIsentress
No pain related info.
  • Combining certain medications can increase the risk of muscle pain (myopathy), muscle damage (rhabdomyolysis), and kidney damage. Talk to your doctor or pharmacist when taking any new medications.
Upsides and benefits
StribildIsentress
  • First-choice treatment for HIV in patients with good kidney function.
  • One tablet contains four different HIV medications.
  • Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) is only taken once daily.
  • There are assistance programs available through the manufacturer of Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) if you need help paying for high insurance copays.
  • If having difficulty swallowing the tablet, consider the chewable tablet or oral suspension.
  • Only one tablet taken two times a day.
  • Can be used for kids 4 weeks and older.
  • May be helpful if other HIV drugs have stopped working since Isentress works differently than most HIV drugs.
Downsides and risks
StribildIsentress
  • Can't be used in patients with kidney problems.
  • Can interact with many other drugs.
  • Tablets, chewable tablets, and the oral suspension all have different doses, so talk to your doctor if you want to switch from one to another.
  • The oral suspension has to be taken within 30 minutes of mixing it.
  • Avoid taking antacids that contain aluminum and/or magnesium while taking Isentress.
  • Let your doctor know right away if while taking Isentress you begin to feel unexplained muscle pain.
Tips from our pharmacists for people taking the medication
StribildIsentress
  • Take around the same time each day.
  • Take with food.
  • If you take antacids, separate it from Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) by at least two hours.
  • Talk to your doctor or pharmacist before starting any new medication while on Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) to prevent drug interactions.
  • Keep your regularly scheduled doctor's and lab appointments. These help ensure your medication is working well and safely.
  • Keep an eye out for any new symptoms or side effects you may start to feel while taking Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir) and report them to your doctor.
  • Set two times during the day, one in the morning and one in the evening that you will remember to take Isentress.
  • Take Isentress with or without food.
  • Isentress can make you tired, so avoid other medications or drinks that will add to the problem.
  • If being used for kids, the dose of Isentress will continue to change as they grow, so keep in touch with their doctor.
Learn more
More about StribildSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir)?
Worth itNot sureNot worth it
More about IsentressSide effectsReviews & ratingsFDA package insert
Have you used Isentress (raltegravir)?
Worth itNot sureNot worth it