Compare Sudafed PE Pressure Pain And Cough vs. Advil Congestion Relief

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sudafed Pe Pressure Pain And Cough (Acetaminophen / Dextromethorphan / Phenylephrine)

Over-the-counter
Relieves coughing and cold symptoms.

Sudafed Pe Pressure Pain And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.

Relieves pain and congestion.

Advil Congestion Relief (Ibuprofen / Phenylephrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.

4.9/ 7 average rating with 1125 reviewsforAdvil Congestion Relief
Upsides
  • Sudafed Pe Pressure Pain And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Advil Congestion Relief (Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
Downsides
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need both of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
Used for
Dosage forms
  • Pill
  • Pill
No pricing information available
No pricing information available
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Reviews
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1125 
73%
think this treatment is worth it
32%
think this treatment works well
7%
think this treatment is a hassle

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Side effects
The Sudafed Pe Pressure Pain And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Advil Congestion Relief (Ibuprofen / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Liver damage

    Taking with alcohol

    ...and 2 more risk factors

  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Chronic cough from an infection

    History of chronic obstructive pulmonary disease (COPD)

    ...and 1 more risk factors

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Harm to unborn babies

    Women of childbearing age

See more detailed risks and warnings
  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Harm to fetus

    Women of childbearing age

  • High blood pressure

    History of high blood pressure

  • Lower kidney function

    Kidney disease

    ...and 4 more risk factors

  • Heart attack or stroke

    History of heart problems

    ...and 2 more risk factors

See more detailed risks and warnings