Compare Sudafed PE Pressure Pain and Mucus vs. Theraflu Daytime Severe Cold and Cough

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sudafed Pe Pressure Pain And Mucus
(Acetaminophen / Guaifenesin / Phenylephrine)

Theraflu Daytime Severe Cold And Cough
(Acetaminophen / Dextromethorphan / Phenylephrine)

Relieves cold symptoms. Sudafed Pe Pressure Pain And Mucus (Acetaminophen / Guaifenesin / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is good for treating multiple cold and flu symptoms, but it's more medicine than you need if you only have one symptom.
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Side effects
Sudafed PE Pressure Pain and MucusTheraflu Daytime Severe Cold and Cough

We haven’t found good data for Sudafed PE Pressure Pain and Mucus side effects.

FDA side effect reports for Sudafed PE Pressure Pain and Mucus »

We haven’t found good data for Theraflu Daytime Severe Cold and Cough side effects.

FDA side effect reports for Theraflu Daytime Severe Cold and Cough »
How it works
Sudafed PE Pressure Pain and MucusTheraflu Daytime Severe Cold and Cough
Sudafed Pe Pressure Pain And Mucus (Acetaminophen / Guaifenesin / Phenylephrine) is a combination medicine that treats cold symptoms. Acetaminophen relieves pain and reduces fever. Phenylephrine is a decongestant that clears your sinuses. Guaifenesin breaks up mucus and phlegm.Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Sudafed PE Pressure Pain and MucusTheraflu Daytime Severe Cold and Cough
Pain reliever
Acetaminophen (APAP)
ExpectorantDecongestantOver-the-counter
Pain reliever
Acetaminophen (APAP)
Cough suppressantDecongestantOver-the-counter
Available as
Sudafed PE Pressure Pain and MucusTheraflu Daytime Severe Cold and Cough
  • Pill
  • Powder
Used for (click to learn more)
Sudafed PE Pressure Pain and MucusTheraflu Daytime Severe Cold and Cough
Risk factors for serious side effects
Sudafed PE Pressure Pain and MucusTheraflu Daytime Severe Cold and Cough
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
    • Women of childbearing age
    Detailed Sudafed Pe Pressure Pain And Mucus (Acetaminophen / Guaifenesin / Phenylephrine) risks & warnings »
    • Drinking more than 3 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
    • History of chronic obstructive pulmonary disease (COPD)
    • History of smoking
    • History of high blood pressure
    • Taking MAO inhibitors
    • Using other medications that affect serotonin
    • History of phenylketonuria (PKU)
    • Women of childbearing age
    Detailed Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) risks & warnings »
    Pregnancy category
    Sudafed PE Pressure Pain and MucusTheraflu Daytime Severe Cold and Cough
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    Sudafed PE Pressure Pain and MucusTheraflu Daytime Severe Cold and Cough
    • Sudafed Pe Pressure Pain And Mucus (Acetaminophen / Guaifenesin / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, congestion, fever, and pain.
    • The decongestant (phenylephrine) has fewer side effects than other decongestants. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
    • Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold and flu symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
    • Since you're taking this with water, it can help you stay hydrated.
    • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
    Downsides and risks
    Sudafed PE Pressure Pain and MucusTheraflu Daytime Severe Cold and Cough
    • Guaifenesin isn’t useful if you have a dry cough without chest congestion.
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
    • You shouldn't use it if you have high blood pressure.
    • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
    • You shouldn't use it if you have high blood pressure.
    • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
    Tips from our pharmacists for people taking the medication
    Sudafed PE Pressure Pain and MucusTheraflu Daytime Severe Cold and Cough
    • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
    • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Starts working in about 30 minutes.
    • Dissolve 1 packet in a cup of hot water and use every 4 hours as needed. Don't use more than 5 packets in 24 hours.
    • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
    • Let your doctor know if your symptoms don't improve in a few days.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    Learn more
    More about Sudafed PE Pressure Pain and MucusSide effectsAlternativesFDA package insert
    More about Theraflu Daytime Severe Cold and CoughSide effectsReviews & ratingsAlternativesFDA package insert