Compare Sudafed vs. Advil Cold and Sinus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sudafed
(Pseudoephedrine)

Advil Cold And Sinus
(Ibuprofen / Pseudoephedrine)

Clears your sinuses. Sudafed (Pseudoephedrine) relieves stuffy nose, but it could keep you up at night. Don't forget your photo ID or you won't be able to buy it in the drugstore.Relieves sinus pain and congestion. Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.273672055427252Sudafed
Reviews for Sudafed (Pseudoephedrine)
82%
of people say Sudafed (Pseudoephedrine) is worth it
45%
say it works well
6%
say it's a big hassle
Reviews for Advil Cold And Sinus (Ibuprofen / Pseudoephedrine)
75%
7% vs. Sudafed (Pseudoephedrine)
34%
11% vs. Sudafed (Pseudoephedrine)
6%
Same vs. Sudafed (Pseudoephedrine)
Side effects
SudafedAdvil Cold and Sinus

We haven’t found good data for Sudafed side effects.

FDA side effect reports for Sudafed »

We haven’t found good data for Advil Cold and Sinus side effects.

FDA side effect reports for Advil Cold and Sinus »
How it works
SudafedAdvil Cold and Sinus
Sudafed (Pseudoephedrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms and sinus pressure. Ibuprofen (an NSAID) relieves pain and reduces fever. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
SudafedAdvil Cold and Sinus
DecongestantPrescription or OTC
Pain reliever
NSAID
DecongestantOver-the-counter
Available as
SudafedAdvil Cold and Sinus
  • Pill
  • Extended release
  • Liquid
  • Pill
Used for (click to learn more)
SudafedAdvil Cold and Sinus
Risk factors for serious side effects
SudafedAdvil Cold and Sinus
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
  • History of seizures
  • Women of childbearing age
Detailed Sudafed (Pseudoephedrine) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
  • History of high blood pressure
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • History of heart problems
  • Age 65 years or older
  • Taking with aspirin
Detailed Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) risks & warnings »
Pregnancy category
SudafedAdvil Cold and Sinus
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.
  • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) for any amount of time.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • It can affect the quality of your sleep, so you can't take it too close to going to bed.
No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
SudafedAdvil Cold and Sinus
  • One of the best over-the-counter options to clear stuffy nose and help you breathe better.
  • Clears nasal congestion better than other decongestants like phenylephrine.
  • Can be helpful in relieving congestion-related headaches and pressure in your ears.
  • Available in regular and extended release forms.
  • Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms. It's good to use if you have congestion, sore throat, headache, or fever.
  • Ibuprofen (a pain reliever) is more effective than acetaminophen at lowering fever and relieving sinus pain.
  • Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
Downsides and risks
SudafedAdvil Cold and Sinus
  • Pseudoephedrine (a decongestant) can make your heart race or make you feel anxious and restless.
  • It can affect the quality of your sleep, so you can't take it too close to going to bed.
  • Can raise blood pressure so check with your doctor before using it if you have high blood pressure or other heart conditions.
  • Sudafed (Pseudoephedrine) isn't as effective after using it for more than 4 days straight.
  • Need to show a photo ID to buy it in the drugstore and there is a limit on how much you can buy each visit.
  • If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
  • Pseudoephedrine, the decongestant in Advil Cold And Sinus (Ibuprofen / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
Tips from our pharmacists for people taking the medication
SudafedAdvil Cold and Sinus
  • You need to show an ID to buy Sudafed (Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Don't take Sudafed (Pseudoephedrine) too close to bedtime since it can keep you awake.
  • Talk to your doctor if your symptoms don't get better in 1 week.
  • Starts working in 30 minutes.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • You need to show an ID to buy Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Take it after eating to avoid getting an upset stomach.
  • Be careful taking Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) if you have a history of bleeding problems or ulcers since it can make them worse.
  • Talk to your doctor if symptoms don't get better in 1 week.
  • Starts working in 30 minutes.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
Learn more
More about SudafedSide effectsReviews & ratingsAlternativesFDA package insert
More about Advil Cold and SinusSide effectsReviews & ratingsAlternativesFDA package insert