Compare Sudafed vs. Flonase

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sudafed (Pseudoephedrine)

Prescription or OTC

Flonase (Fluticasone)

Prescription or OTC
Clears your sinuses.

Sudafed (Pseudoephedrine) relieves stuffy nose, but it could keep you up at night. Don't forget your photo ID or you won't be able to buy it in the drugstore.

5.3/ 7 average rating with 1740 reviewsforSudafed
Relieves allergy symptoms.

Flonase (Fluticasone) is a good first-choice medicine for treating a runny or stuffy nose caused by allergies, and it's cheaper than some alternatives.

5.0/ 7 average rating with 890 reviewsforFlonase
Upsides
  • One of the best over-the-counter options to clear stuffy nose and help you breathe better.
  • Clears nasal congestion better than other decongestants like phenylephrine.
  • Can be helpful in relieving congestion-related headaches and pressure in your ears.
  • Available in regular and extended release forms.
  • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
  • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
  • Can be used as needed to help control symptoms in people age 13 years or older.
  • Available as a generic medication.
Downsides
  • Pseudoephedrine (a decongestant) can make your heart race or make you feel anxious and restless.
  • It can affect the quality of your sleep, so you can't take it too close to going to bed.
  • Can raise blood pressure so check with your doctor before using it if you have high blood pressure or other heart conditions.
  • Sudafed (Pseudoephedrine) isn't as effective after using it for more than 4 days straight.
  • Need to show a photo ID to buy it in the drugstore and there is a limit on how much you can buy each visit.
  • Flonase (Fluticasone) doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
  • Needs to be primed (pressed/pumped until a fine spray appears) up to six times prior to using it for the first time, or if you haven't used it in 2 weeks.
  • Since the medicine in Flonase (Fluticasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
Used for
Dosage forms
  • Pill
  • Extended release
  • Liquid
  • Nasal spray
Price
No pricing information available
Lowest price near you
$200.08
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Reviews
1740 
82%
think this treatment is worth it
45%
think this treatment works well
6%
think this treatment is a hassle

Have you used Sudafed (Pseudoephedrine)?

Leave a review
890 
72%
think this treatment is worth it
43%
think this treatment works well
7%
think this treatment is a hassle

Have you used Flonase (Fluticasone)?

Leave a review
Side effects
The Sudafed (Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
The Flonase (Fluticasone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • High blood pressure

    History of high blood pressure

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Seizures

    History of seizures

  • Harm to fetus

    Women of childbearing age

See more detailed risks and warnings
  • Adrenal suppression

    Switching from oral or injectable steroids to inhaled, especially if used long term

    ...and 1 more risk factors

  • Decrease in growth in children and teenagers

    Long-term use

    ...and 1 more risk factors

  • Adrenal suppression

    Switching from oral or injectable steroids to inhaled, especially if used long term

    ...and 1 more risk factors

  • Thrush in the nose and throat

    Long-term use

  • Reduced immune system

    Exposure to immunizable diseases (chickenpox and measles)

    ...and 1 more risk factors

  • Decreased wound healing

    Surgery or trauma to the nose or sinuses

  • Changes in the nasal septum

    Long-term use

See more detailed risks and warnings