Compare Sudafed vs. Nyquil Cold And Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sudafed
(pseudoephedrine)

Nyquil Cold And Flu
(acetaminophen / dextromethorphan / doxylamine)

Clears your sinuses. Sudafed (Pseudoephedrine) relieves stuffy nose, but it could keep you up at night. Don't forget your photo ID or you won't be able to buy it in the drugstore.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.28Sudafed
Reviews for Sudafed
82%
of people (All ages) say Sudafed is worth it
45%
say it works well
6%
say it's a big hassle
1740 reviews
Have you used Sudafed (pseudoephedrine)?
Worth itNot sureNot worth it
Reviews for Nyquil Cold And Flu
83%
-1% worse vs. Sudafed
42%
+3% better vs. Sudafed
7%
+1% better vs. Sudafed
1188 reviews
Have you used Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)?
Worth itNot sureNot worth it
Side effects
SudafedNyquil Cold And Flu

We haven’t found good data for Sudafed side effects.

FDA side effect reports for Sudafed »

We haven’t found good data for Nyquil Cold And Flu side effects.

FDA side effect reports for Nyquil Cold And Flu »
How it works
SudafedNyquil Cold And Flu
Sudafed (Pseudoephedrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
SudafedNyquil Cold And Flu
Prescription or OTCOver-the-counter
Available as
SudafedNyquil Cold And Flu
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Liquid
Used for
SudafedNyquil Cold And Flu
Risk factors for serious side effects
SudafedNyquil Cold And Flu
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
  • History of seizures
  • Women of childbearing age
Detailed Sudafed (pseudoephedrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Using other medications that affect serotonin
  • Taking with alcohol
Detailed Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
SudafedNyquil Cold And Flu
No alcohol related info.
  • Avoid using alcohol and other drugs that make you drowsy.
Kidneys and liver
SudafedNyquil Cold And Flu
No kidneys and liver related info.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Pain
SudafedNyquil Cold And Flu
No pain related info.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Sleep
SudafedNyquil Cold And Flu
  • It can affect the quality of your sleep, so you can't take it too close to going to bed.
No sleep related info.
Upsides and benefits
SudafedNyquil Cold And Flu
  • One of the best over-the-counter options to clear stuffy nose and help you breathe better.
  • Clears nasal congestion better than other decongestants like phenylephrine.
  • Can be helpful in relieving congestion-related headaches and pressure in your ears.
  • Available in regular and extended release forms.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
Downsides and risks
SudafedNyquil Cold And Flu
  • Pseudoephedrine (a decongestant) can make your heart race or make you feel anxious and restless.
  • It can affect the quality of your sleep, so you can't take it too close to going to bed.
  • Can raise blood pressure so check with your doctor before using it if you have high blood pressure or other heart conditions.
  • Sudafed (Pseudoephedrine) isn't as effective after using it for more than 4 days straight.
  • Need to show a photo ID to buy it in the drugstore and there is a limit on how much you can buy each visit.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
SudafedNyquil Cold And Flu
  • Starts working in 30 minutes.
  • You need to show an ID to buy Sudafed (Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Don't take Sudafed (Pseudoephedrine) too close to bedtime since it can keep you awake.
  • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
  • Talk to your doctor if your symptoms don't get better in 1 week.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about SudafedSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Sudafed (pseudoephedrine)?
Worth itNot sureNot worth it
More about Nyquil Cold And FluSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)?
Worth itNot sureNot worth it