Compare Sulfasalazine vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Azulfidine
(sulfasalazine)

Humira
(adalimumab)

Reduces inflammation. Azulfidine (Sulfasalazine) is used for moderate to severe inflammatory bowel conditions, and with other meds for treating rheumatoid arthritis.Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.
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Coupons for Sulfasalazine
Best available price for 120 (500mg) tablets of sulfasalazine
Coupons for Humira
Best available price for 2 (2 pens of 40mg/0.8ml) cartons of humira
Reviews & ratings
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Have you used Azulfidine (sulfasalazine)?
Worth itNot sureNot worth it
Reviews for Humira
60%
-60% worse vs. Sulfasalazine
51%
-51% worse vs. Sulfasalazine
26%
+26% better vs. Sulfasalazine
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
Side effects
SulfasalazineHumira

We haven’t found good data for Sulfasalazine side effects.

FDA side effect reports for Sulfasalazine »
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
How it works
SulfasalazineHumira
Azulfidine (Sulfasalazine) is an anti-inflammatory drug that reduces inflammation and pain. It treats inflammatory bowel diseases and rheumatoid arthritis.Humira (adalimumab) is a TNF blocker which stops inflammation.
Type of medication
SulfasalazineHumira
Prescription onlyPrescription only
Available as
SulfasalazineHumira
  • Pill
  • Extended release
  • Injection
Used for
SulfasalazineHumira
Risk factors for serious side effects
SulfasalazineHumira
    Detailed Azulfidine (sulfasalazine) risks & warnings »
    • Taking other immunosuppressant medications such as Kineret or Orencia
    • Age 65 or older
    • Active, chronic, or recurrent infection
    • Comorbidities
    • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
    Detailed Humira (adalimumab) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Food
    SulfasalazineHumira
    • Swallow tablets whole, and take after a meal with a full glass of water.
    No food related info.
    Kidneys and liver
    SulfasalazineHumira
    • Severe hypersensitivity reactions can include internal organ involvement, such as hepatitis (liver), nephritis (kidney), myocarditis (heart), blood abnormalities, or pneumonitis (lungs).
    • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
    No kidneys and liver related info.
    Upsides and benefits
    SulfasalazineHumira
    • When taken consistently, Azulfidine (Sulfasalazine) can control your symptoms of ulcerative colitis and other bowel diseases.
    • Azulfidine (Sulfasalazine) is usually used in combination with other medications to control rheumatoid arthritis.
    • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
    • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
    • Humira (adalimumab) treats many different autoimmune conditions.
    • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
    Downsides and risks
    SulfasalazineHumira
    • You need to have blood tests every 3 months when taking Azulfidine (Sulfasalazine).
    • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
    • Can't take Azulfidine (Sulfasalazine) if you are allergic to aspirin or sulfa medications.
    • Azulfidine (Sulfasalazine) shouldn't be used if you are breastfeeding.
    • Not first-choice treatment for rheumatoid arthritis.
    • Humira (adalimumab) is an injection and not an oral medication.
    • Humira (adalimumab) is expensive because there's no generic available yet.
    • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
    • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
    • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
    Tips from our pharmacists for people taking the medication
    SulfasalazineHumira
    • Don't use if you are allergic to sulfa drugs or aspirin.
    • Swallow tablets whole, and take after a meal with a full glass of water.
    • Drink at least six glasses of water daily while on this.
    • Continue to take Azulfidine (Sulfasalazine) even once you feel better.
    • Read the information that come with your medication in the drugstore since there are many conditions you should be aware of before taking Azulfidine (Sulfasalazine).
    • Can cause an orange color in your urine or skin.
    • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
    • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
    • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
    • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
    • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
    Learn more
    More about SulfasalazineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Azulfidine (sulfasalazine)?
    Worth itNot sureNot worth it
    More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Humira (adalimumab)?
    Worth itNot sureNot worth it