Sulfasalazine vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Reduces inflammation. Azulfidine (Sulfasalazine) is used for moderate to severe inflammatory bowel conditions, and with other meds for treating rheumatoid arthritis.Calms down your immune system. Humira (Adalimumab) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.
How it works
Azulfidine (Sulfasalazine) is an anti-inflammatory drug that reduces inflammation and pain. It treats inflammatory bowel diseases and rheumatoid arthritis.Humira (Adalimumab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
Biological response modifier
Prescription only
Biological response modifier
Prescription only
Available as
  • Pill
  • Extended release
  • Injection
Used for (click to learn more)
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Humira (Adalimumab)
+59% vs. Azulfidine (Sulfasalazine)
+49% vs. Azulfidine (Sulfasalazine)
-26% vs. Azulfidine (Sulfasalazine)
Side effects

We haven’t found good data for Sulfasalazine side effects.

FDA side effect reports for Sulfasalazine »
  • Injection site reactions 6%
  • Rash 6%
  • Positive titers 5%
  • Upper respiratory infection 4%
  • Headache 4%
  • Abdominal pain 3%
  • Urinary tract infection 3%
  • High blood pressure 2%
  • Alkaline phosphatase increased 2%
  • High blood lipid levels 2%
More Humira side effects »
Risk factors for serious side effects
          Detailed Azulfidine (Sulfasalazine) risks & warnings »
            • History of heart failure
            • Taking other immunosuppressant drugs
            • Age 60 or older
            • Taking other immunosuppressant drugs
            • History of malignancy
            • History of neurologic condition
              Detailed Humira (Adalimumab) risks & warnings »
              Pregnancy category
              BFDA pregnancy category (Probably safe)

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              See the FDA package insert
              BFDA pregnancy category (Probably safe)

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              See the FDA package insert
              No specific alcohol-related info.No specific alcohol-related info.
              • Swallow tablets whole, and take after a meal with a full glass of water.
              No specific food-related info.
              Kidneys and liver
              • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
              • Complete blood counts should be done before starting Azulfidine (Sulfasalazine) and every other week during the first three months of treatment. Since kidney damage can occur, you'll need a urinalysis and an assessment of your kidney function periodically during treatment.
              • Severe hypersensitivity reactions can include internal organ involvement, such as hepatitis (liver), nephritis (kidney), myocarditis (heart), blood abnormalities, or pneumonitis (lungs).
              No specific kidneys and liver-related info.
              No specific sex-related info.No specific sex-related info.
              No specific sleep-related info.No specific sleep-related info.
              No specific weight-related info.
              • Humira (Adalimumab) can increase your risk of serious or life-threatening bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Humira (Adalimumab). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
              Upsides and benefits
              • When taken consistently, Azulfidine (Sulfasalazine) can control your symptoms of ulcerative colitis and other bowel diseases.
              • Azulfidine (Sulfasalazine) is usually used in combination with other medications to control rheumatoid arthritis.
              • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
              • Most people feel it's worth the hassle.
              • Once you've learned the correct way to use Humira, you can inject the medicine yourself without going to your doctor's office.
              • It's available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
              • It's an alternative for people with Crohn's disease who stopped getting better on other TNF-blockers or had side effects that made them switch.
              Downsides and risks
              • You need to have blood tests every 3 months when taking Azulfidine (Sulfasalazine).
              • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
              • Can't take Azulfidine (Sulfasalazine) if you are allergic to aspirin or sulfa medications.
              • Azulfidine (Sulfasalazine) shouldn't be used if you are breastfeeding.
              • It's an injection.
              • It's expensive because there's no generic available yet.
              • Humira lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
              • You're first dose of Humira will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
              • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
              • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
              Tips from our pharmacists for people taking the medication
              • Don't use if you are allergic to sulfa drugs or aspirin.
              • Swallow tablets whole, and take after a meal with a full glass of water.
              • Drink at least six glasses of water daily while on this.
              • Continue to take Azulfidine (Sulfasalazine) even once you feel better.
              • Read the information that come with your medication in the drugstore since there are many conditions you should be aware of before taking Azulfidine (Sulfasalazine).
              • Can cause an orange color in your urine or skin.
              • Humira (Adalimumab) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
              • Humira (Adalimumab) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
              • You'll need to have a TB test before you start using Humira (Adalimumab).
              • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
              • Don't inject Humira (Adalimumab) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
              • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
              Learn more
              More about SulfasalazineSide effectsReviews & ratingsAlternativesFDA package insert
              More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert