Compare Sulfasalazine vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Azulfidine (Sulfasalazine)

Prescription only

Humira (adalimumab)

Prescription only
Reduces inflammation.

Azulfidine (Sulfasalazine) is used for moderate to severe inflammatory bowel conditions, and with other meds for treating rheumatoid arthritis.

Calms down the immune system.

Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.

4.9/ 7 average rating with 182 reviewsforHumira
Upsides
  • When taken consistently, Azulfidine (Sulfasalazine) can control your symptoms of ulcerative colitis and other bowel diseases.
  • Azulfidine (Sulfasalazine) is usually used in combination with other medications to control rheumatoid arthritis.
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
Downsides
  • You need to have blood tests every 3 months when taking Azulfidine (Sulfasalazine).
  • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
  • Can't take Azulfidine (Sulfasalazine) if you are allergic to aspirin or sulfa medications.
  • Azulfidine (Sulfasalazine) shouldn't be used if you are breastfeeding.
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
Used for
Dosage forms
  • Pill
  • Extended release
  • Injection
Price
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$15.66
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$4537.05
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Reviews
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182 
60%
think this treatment is worth it
51%
think this treatment works well
26%
think this treatment is a hassle

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Side effects
The Azulfidine (Sulfasalazine) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Upper airway infection
    17%
  • Headache
    12%
  • Rash
    12%
  • Sinus infection
    11%
  • Nausea
    9%
  • Injection site reactions
    8%
  • Urinary tract infection
    8%
  • Flu syndrome
    7%
  • Stomach pain
    7%
  • High cholesterol
    7%
See more detailed side effects
Risks and warnings
See more detailed risks and warnings
  • Serious infections

    Taking other immunosuppressant medications such as Kineret or Orencia

    ...and 3 more risk factors

  • Cancers

    Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)

    ...and 3 more risk factors

  • Heart problems

    History of heart failure

  • Nervous system effects

    Preexisting or recently acquired neurologic condition

See more detailed risks and warnings