Compare Sulfasalazine vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Azulfidine
(Sulfasalazine)

Humira
(Adalimumab)

Reduces inflammation. Azulfidine (Sulfasalazine) is used for moderate to severe inflammatory bowel conditions, and with other meds for treating rheumatoid arthritis.Calms down your immune system. Humira (Adalimumab) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.
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Reviews & ratings
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Have you used Azulfidine (Sulfasalazine)?
Worth itNot sureNot worth it
Reviews for Humira (Adalimumab)
60%
+60% vs. Azulfidine (Sulfasalazine)
51%
+51% vs. Azulfidine (Sulfasalazine)
26%
26% vs. Azulfidine (Sulfasalazine)
182 reviews
Have you used Humira (Adalimumab)?
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Side effects
SulfasalazineHumira

We haven’t found good data for Sulfasalazine side effects.

FDA side effect reports for Sulfasalazine »

The Humira FDA package insert doesn’t have numbers about how common side effects are.

More about Humira side effects »
How it works
SulfasalazineHumira
Azulfidine (Sulfasalazine) is an anti-inflammatory drug that reduces inflammation and pain. It treats inflammatory bowel diseases and rheumatoid arthritis.Humira (Adalimumab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
SulfasalazineHumira
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Available as
SulfasalazineHumira
  • Pill
  • Extended release
  • Injection
Used for (click to learn more)
SulfasalazineHumira
Risk factors for serious side effects
SulfasalazineHumira
    Detailed risks & warnings »
    • History of heart failure
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • History of malignancy
    • History of neurologic condition
    Detailed risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Food
    SulfasalazineHumira
    • Swallow tablets whole, and take after a meal with a full glass of water.
    No food related info.
    Kidneys and liver
    SulfasalazineHumira
    • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
    • Severe hypersensitivity reactions can include internal organ involvement, such as hepatitis (liver), nephritis (kidney), myocarditis (heart), blood abnormalities, or pneumonitis (lungs).
    No kidneys and liver related info.
    Upsides and benefits
    SulfasalazineHumira
    • When taken consistently, Azulfidine (Sulfasalazine) can control your symptoms of ulcerative colitis and other bowel diseases.
    • Azulfidine (Sulfasalazine) is usually used in combination with other medications to control rheumatoid arthritis.
    • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
    • Most people feel it's worth the hassle.
    • Once you've learned the correct way to use Humira, you can inject the medicine yourself without going to your doctor's office.
    • It's available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
    • It's an alternative for people with Crohn's disease who stopped getting better on other TNF-blockers or had side effects that made them switch.
    Downsides and risks
    SulfasalazineHumira
    • You need to have blood tests every 3 months when taking Azulfidine (Sulfasalazine).
    • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
    • Can't take Azulfidine (Sulfasalazine) if you are allergic to aspirin or sulfa medications.
    • Azulfidine (Sulfasalazine) shouldn't be used if you are breastfeeding.
    • It's an injection.
    • It's expensive because there's no generic available yet.
    • Humira lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
    • You're first dose of Humira will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
    • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
    • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
    Tips from our pharmacists for people taking the medication
    SulfasalazineHumira
    • Don't use if you are allergic to sulfa drugs or aspirin.
    • Swallow tablets whole, and take after a meal with a full glass of water.
    • Drink at least six glasses of water daily while on this.
    • Continue to take Azulfidine (Sulfasalazine) even once you feel better.
    • Read the information that come with your medication in the drugstore since there are many conditions you should be aware of before taking Azulfidine (Sulfasalazine).
    • Can cause an orange color in your urine or skin.
    • Humira (Adalimumab) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
    • Humira (Adalimumab) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
    • You'll need to have a TB test before you start using Humira (Adalimumab).
    • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
    • Don't inject Humira (Adalimumab) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
    • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
    Learn more
    More about SulfasalazineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Azulfidine (Sulfasalazine)?
    Worth itNot sureNot worth it
    More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Humira (Adalimumab)?
    Worth itNot sureNot worth it