Compare Sulfasalazine vs. Remicade

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Reduces inflammation. Azulfidine (Sulfasalazine) is used for moderate to severe inflammatory bowel conditions, and with other meds for treating rheumatoid arthritis.Calms down your immune system. Remicade (Infliximab) is very effective at calming down your immune system, but you have to get each dose at your doctor's office and watch out for serious side effects.
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Reviews & ratings
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Reviews for Remicade (Infliximab)
+77% vs. Azulfidine (Sulfasalazine)
+65% vs. Azulfidine (Sulfasalazine)
13% vs. Azulfidine (Sulfasalazine)
Side effects

We haven’t found good data for Sulfasalazine side effects.

FDA side effect reports for Sulfasalazine »
  • Infusion reaction 13%
  • Infections 11%
More Remicade side effects »
How it works
Azulfidine (Sulfasalazine) is an anti-inflammatory drug that reduces inflammation and pain. It treats inflammatory bowel diseases and rheumatoid arthritis.Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
Biological response modifier
Prescription only
Biological response modifier
Prescription only
Available as
  • Pill
  • Extended release
  • Injection
Used for (click to learn more)
Risk factors for serious side effects
          Detailed Azulfidine (Sulfasalazine) risks & warnings »
            • History of heart failure
            • Taking other immunosuppressant drugs
            • Age 60 or older
            • Taking other immunosuppressant drugs
            • History of malignancy
            • History of neurologic condition
                Detailed Remicade (Infliximab) risks & warnings »
                Pregnancy category
                BFDA pregnancy category (Probably safe)

                Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                See the FDA package insert
                BFDA pregnancy category (Probably safe)

                Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                See the FDA package insert
                No specific alcohol-related info.No specific alcohol-related info.
                • Swallow tablets whole, and take after a meal with a full glass of water.
                No specific food-related info.
                Kidneys and liver
                • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
                • Complete blood counts should be done before starting Azulfidine (Sulfasalazine) and every other week during the first three months of treatment. Since kidney damage can occur, you'll need a urinalysis and an assessment of your kidney function periodically during treatment.
                • Severe hypersensitivity reactions can include internal organ involvement, such as hepatitis (liver), nephritis (kidney), myocarditis (heart), blood abnormalities, or pneumonitis (lungs).
                No specific kidneys and liver-related info.
                No specific sex-related info.No specific sex-related info.
                No specific sleep-related info.No specific sleep-related info.
                No specific weight-related info.
                • Remicade (Infliximab) can increase your risk of serious or life-threatening bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Remicade (Infliximab). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
                • Although rare, Remicade (Infliximab) can cause serious liver injury. You'll need to have your liver enzymes tested regularly. If liver enzymes are significantly elevated and you have appetite/weight loss, stomach discomfort, vomiting, and notice dark urine, yellowing of skin/eyes, change in stool color, and skin rash you should stop treatment with Remicade (Infliximab) until you can be completely assessed,
                Upsides and benefits
                • When taken consistently, Azulfidine (Sulfasalazine) can control your symptoms of ulcerative colitis and other bowel diseases.
                • Azulfidine (Sulfasalazine) is usually used in combination with other medications to control rheumatoid arthritis.
                • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
                • Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
                • Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
                Downsides and risks
                • You need to have blood tests every 3 months when taking Azulfidine (Sulfasalazine).
                • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
                • Can't take Azulfidine (Sulfasalazine) if you are allergic to aspirin or sulfa medications.
                • Azulfidine (Sulfasalazine) shouldn't be used if you are breastfeeding.
                • You have to get every dose through an IV infusion at your doctor's office.
                • It's expensive because there's no generic available yet.
                • Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
                • Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
                • Not the best choice if you have heart failure.
                • Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
                Tips from our pharmacists for people taking the medication
                • Don't use if you are allergic to sulfa drugs or aspirin.
                • Swallow tablets whole, and take after a meal with a full glass of water.
                • Drink at least six glasses of water daily while on this.
                • Continue to take Azulfidine (Sulfasalazine) even once you feel better.
                • Read the information that come with your medication in the drugstore since there are many conditions you should be aware of before taking Azulfidine (Sulfasalazine).
                • Can cause an orange color in your urine or skin.
                • Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
                • It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
                • It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
                • You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
                • Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
                • If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.
                Learn more
                More about SulfasalazineSide effectsReviews & ratingsAlternativesFDA package insert
                More about RemicadeSide effectsReviews & ratingsAlternativesFDA package insert