Compare Surmontil vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Surmontil
(trimipramine)

Norpramin
(desipramine)

Improves your mood. Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Surmontil
Best available price for 30 (100mg) capsules of surmontil
Coupons for desipramine
Best available price for 30 (25mg) tablets of desipramine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
Side effects
Surmontildesipramine

The Surmontil FDA package insert doesn’t have numbers about how common side effects are.

More about Surmontil side effects »

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
How it works
Surmontildesipramine
Surmontil (trimipramine) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood.Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.
Type of medication
Surmontildesipramine
Prescription onlyPrescription only
Available as
Surmontildesipramine
  • Pill
  • Pill
Used for
Surmontildesipramine
Risk factors for serious side effects
Surmontildesipramine
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Surmontil (trimipramine) risks & warnings »
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Norpramin (desipramine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Food
Surmontildesipramine
  • Can be taken with or without food.
No food related info.
Upsides and benefits
Surmontildesipramine
  • Surmontil (trimipramine) is part of the first choice medicines to treat depression.
  • Available in generic and in three different strengths.
  • Can be taken once a day, usually before you go to bed.
  • Can be taken with or without food.
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
Downsides and risks
Surmontildesipramine
  • You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
  • Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
  • Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
Tips from our pharmacists for people taking the medication
Surmontildesipramine
  • Take Surmontil (trimipramine) at night since it can make you sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you forget a dose, take it as soon as you remember, unless it's time for your next dose. Don't take extra medicine to make up for the missed dose.
  • Don't stop taking Surmontil (trimipramine) without talking to your doctor first.
  • Be very careful getting up if you've been sitting or lying down for a while since you can feel dizzy.
  • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
  • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
  • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
  • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
Learn more
More about SurmontilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it
More about desipramineSide effectsAlternativesFDA package insert
Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it