Compare Sustiva vs. Edurant

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Sustiva
(efavirenz)

Edurant
(rilpivirine)

Works with other medicines to treat HIV infection. Sustiva (efavirenz) is one of the most widely used and effective components of an HIV medication regimen. However, it is not a first-line choice because it can have a lot of side effects.Works with other medications to treat HIV infection. Edurant (rilpivirine) is a good HIV drug that has to be used in combination with other HIV medications in patients who are new to treatment or are looking for alternatives to a current HIV regimen.
Reviews & ratings
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Have you used Sustiva (efavirenz)?
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Have you used Edurant (rilpivirine)?
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Side effects
SustivaEdurant
  • Skin rash 16%
  • Diarrhea 14%
  • Pain 13%
  • Nausea 10%
  • Dizziness 9%
  • Itching 9%
  • Fatigue 8%
  • Headache 8%
More Sustiva side effects »
  • Depressive disorders 5%
  • Headache 3%
  • Insomnia 3%
  • Rash 3%
  • Abdominal pain 2%
  • Fatigue 2%
  • Abnormal dreams 2%
More Edurant side effects »
How it works
SustivaEdurant
Sustiva (efavirenz) is a Non-Nucleoside reverse transcriptase inhibitor (NNRTI). It treats HIV by stopping the virus from replicating within cells in your immune system.Edurant (rilpivirine) is a Non-nucleoside reverse transcriptase inhibitor (NNRTI). It treats HIV by stopping the virus from replicating within cells in your immune system.
Type of medication
SustivaEdurant
Prescription only
Available as
SustivaEdurant
  • Pill
  • Pill
Used for
SustivaEdurant
Risk factors for serious side effects
SustivaEdurant
  • Starting Sustiva (efavirenz) for the first few weeks.
  • Taking alcohol or other drugs that also affect your nervous system
  • HIV treatment
  • History of liver damage
  • Alcohol intake
Detailed Sustiva (efavirenz) risks & warnings »
  • History of mental health problems
  • Exposure to other infections
  • Start of a new HIV medication
  • Change in HIV therapy
  • Prior severe allergic reaction to Edurant (rilpivirine)
Detailed Edurant (rilpivirine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
SustivaEdurant
No food related info.
  • Take each dose with a meal.
Kidneys and liver
SustivaEdurant
  • Liver damage has been reported in patients who use Sustiva (efavirenz). Your doctor might do blood tests to check your liver regularly. If you notice yellowing of the eyes or the skin, or dark urine, talk to your doctor right away.
  • Can be used in patients with mild to moderate kidney damage.
  • Can be used in patients with mild or moderate kidney damage.
Sleep
SustivaEdurant
  • Some patients experience central nervous system side effects when starting Sustiva (efavirenz), such as dizziness, trouble sleeping, difficulty concentrating, drowsiness, and strange dreams. Taking Sustiva (efavirenz) at bedtime will help lower the risk of experiencing these side effects. These symptoms are common in the first few weeks of starting treatment and usually go away. If symptoms don't improve or are preventing you from taking your medications regularly, let your doctor know.
No sleep related info.
Upsides and benefits
SustivaEdurant
  • If first-line choices for HIV medications are not an option, Sustiva (efavirenz) would be a good alternative to consider.
  • Only taken once daily.
  • Sustiva (efavirenz) is available in combination tablets.
  • Can be used in patients with mild to moderate kidney damage.
  • Can be used in children who are at least 3 months old.
  • Generally well tolerated.
  • Taken only once daily.
  • Edurant (rilpivirine) is available in other combination tablets.
  • Can be used in patients with mild or moderate kidney damage.
Downsides and risks
SustivaEdurant
  • Not suggested for women who plan on becoming pregnant.
  • Many people exerience intolerable side effects (eg. insomnia, dizziness, abnormal dreams, confusion), which make it hard to take the medication regularly.
  • Cannot be taken alone for treatment of HIV.
  • Must be taken in combination with other HIV drugs to treat HIV. Cannot be taken alone as treatment.
  • Must be taken with a meal.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Edurant (rilpivirine). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Edurant (rilpivirine).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Not recommended for children under 12 years old.
Tips from our pharmacists for people taking the medication
SustivaEdurant
  • Side effects such as dizziness, insomnia, and/or abnormal dreams are common within the first few weeks of starting Sustiva (efavirenz). Talk to your doctor if these side effects last longer or are preventing you from taking your medication regularly.
  • Should be taken on an empty stomach at bedtime to reduce side effects.
  • Women taking Sustiva (efavirenz) should be on effective form(s) of birth control, as Sustiva (efavirenz) can cause birth defects.
  • If swallowing the capsule is difficult, you may open the capsules and sprinkle/mix the contents over a small amount of food (eg. applesause, yogurt) before taking.
  • Talk to your doctor or pharmacist before starting any new medication while on Sustiva (efavirenz) to prevent drug interactions.
  • Keep your regularly scheduled doctor and lab appointments. These help ensure your medication is working well and safely.
  • Edurant (rilpivirine) should be taken at the same time everyday.
  • For missed doses, take one if you remember within 12 hours of your regularly scheduled time. Don't take two doses at the same time.
  • Take each dose with a meal.
  • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your doctor.
Learn more
More about SustivaSide effectsAlternativesFDA package insert
Have you used Sustiva (efavirenz)?
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More about EdurantSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Edurant (rilpivirine)?
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