Compare Sustiva vs. Intelence

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Works with other medicines to treat HIV infection.

Sustiva (efavirenz) is one of the most widely used and effective components of an HIV medication regimen. However, it is not a first-line choice because it can have a lot of side effects.

Works with other medicines to treat HIV infection.

Intelence (etravirine) can be an option for patients who are already taking HIV medications but are in need of improving their current HIV drug regimen.

Upsides
  • If first-line choices for HIV medications are not an option, Sustiva (efavirenz) would be a good alternative to consider.
  • Only taken once daily.
  • Sustiva (efavirenz) is available in combination tablets.
  • Can be used in patients with mild to moderate kidney damage.
  • Can be used in children who are at least 3 months old.
  • Intelence (etravirine) has a lower rate of failure due to single HIV mutations compared to other HIV drugs in its class.
  • Can be used in patients with kidney damage.
  • If swallowing a tablet is difficult, you can dissolve Intelence (etravirine) in water and drink it.
  • Can used by children 6 years and older.
Downsides
  • Not suggested for women who plan on becoming pregnant.
  • Many people exerience intolerable side effects (eg. insomnia, dizziness, abnormal dreams, confusion), which make it hard to take the medication regularly.
  • Cannot be taken alone for treatment of HIV.
  • Taken twice daily.
  • Should be taken after meals.
  • Not for use in patients who are new to HIV medications.
  • Intelence (etravirine) can interact with a significant number of drugs.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price
$1007.22
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Lowest price
$1206.70
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Side effects
19possible side effects
  • Skin rash
    16%
  • Diarrhea
    14%
  • Pain
    13%
  • Nausea
    10%
  • Dizziness
    9%
  • Itching
    9%
  • Fatigue
    8%
  • Headache
    8%
  • Insomnia
    7%
  • Vomiting
    6%
  • Trouble concentrating
    5%
  • Depression
    5%
  • Indigestion
    4%
  • Anxiety
    4%
  • Abnormal dreams
    3%
  • Abdominal pain
    3%
  • Sleepiness
    2%
  • Nervousness
    2%
  • Loss of appetite
    2%
See more detailed side effects
The Intelence (etravirine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Central nervous system (CNS) effects
    • Starting Sustiva (efavirenz) for the first few weeks.
    • Taking alcohol or other drugs that also affect your nervous system
  • Fat redistribution
    • HIV treatment
  • Liver damage
    • History of liver damage
    • Alcohol intake
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Psychiatric effects
    • History of mental illness
    • History of substance abuse
  • Rash
    • History of severe skin reactions
    • Children
See more detailed risks and warnings
  • Severe skin reactions
    • Use of Intelence (etravirine)
  • Fat redistribution
    • HIV treatment
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Drug interactions
    • Taking many other medicines
See more detailed risks and warnings