Compare Tagamet vs. Alka-Seltzer

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tagamet
(cimetidine)

Alka-Seltzer Original
(aspirin / citric acid / sodium bicarbonate)

Treats heartburn. Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.Relieves heartburn, headache, and body pains. Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) gives quick relief for headache, body pains, and upset tummies, but might be hard to swallow if you don't like the taste or fizz.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Tagamet
Best available price for 60 (400mg) tablets of cimetidine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.64Tagamet
Reviews for Tagamet
63%
of people (All ages) say Tagamet is worth it
36%
say it works well
12%
say it's a big hassle
632 reviews
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
Reviews for Alka-Seltzer
81%
-18% worse vs. Tagamet
52%
-16% worse vs. Tagamet
8%
-4% worse vs. Tagamet
1055 reviews
Have you used Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate)?
Worth itNot sureNot worth it
Side effects
TagametAlka-Seltzer
  • Headache 2%
More Tagamet side effects »

We haven’t found good data for Alka-Seltzer side effects.

FDA side effect reports for Alka-Seltzer »
How it works
TagametAlka-Seltzer
Tagamet (cimetidine) reduces acid production in your stomach.Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) is a combination medicine. Sodium bicarbonate is an antacid that relieves heartburn and acid tummy (indigestion). Aspirin is a pain reliever that treats headache and body pains.
Type of medication
TagametAlka-Seltzer
Prescription or OTCOver-the-counter
Available as
TagametAlka-Seltzer
  • Pill
  • Liquid
  • Chewable tablet
  • Effervescent tablet
Used for
TagametAlka-Seltzer
Risk factors for serious side effects
TagametAlka-Seltzer
  • Elderly
  • Kidney problems
  • Liver problems
  • Dementia
  • Asthma
Detailed Tagamet (cimetidine) risks & warnings »
  • Current kidney disease
  • Kidney dialysis
  • Age 65 or older
  • Congestive heart failure (CHF)
  • High blood pressure
Detailed Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Food
TagametAlka-Seltzer
No food related info.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
TagametAlka-Seltzer
  • Tagamet (cimetidine) can cause confusion if you have kidney or liver problems, dementia, or if you are over 60 years old. Talk to your doctor or pharmacist about alternative medicines if you have any of these conditions.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • If you have kidney or hyperparathyroid disease Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) can build up in your blood. This may can cause toxic levels of sodium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate); a different antacid would be better for you.
Upsides and benefits
TagametAlka-Seltzer
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
  • Works great if you have an upset stomach and a headache or body pain at the same time.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
Downsides and risks
TagametAlka-Seltzer
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Because it has aspirin in it, it increases the risk of bleeding, especially if you take any other blood thinning medicine.
  • Can't be used by people with allergy to aspirin.
  • You may not like the taste or fizz.
Tips from our pharmacists for people taking the medication
TagametAlka-Seltzer
  • Take 30 minutes before eating for maximum heartburn relief.
  • Talk to your doctor if you don't see any improvement after 2 weeks.
  • Talk to your doctor if you end up using this medicine more than 2 times a week.
  • Let your doctor or pharmacist know about any other medicines or supplements that you are taking because Tagamet (cimetidine) can interfere with how a lot of other medicines work.
  • Don't take Alka-Seltzer if you're allergic to aspirin.
  • Take it with food to lower the chance of an upset stomach.
  • This medicine isn't recommended for kids 12 and younger because it has aspirin in it.
  • Stop taking this right away and talk to your doctor if you have ringing in your ears, rash, trouble breathing, unusual bleeding, or nausea or vomiting that doesn't go away.
  • Having a dental or medical procedure? You may need to stop taking this before the big day. Ask your dentist or doctor.
  • Alka-Seltzer contains sodium. If you need to follow a low sodium diet a different medication would be better for you.
  • Not a good choice if you have stomach bleeding, bleeding problems, diabetes, or gout, or if you're taking medicines to thin your blood.
Learn more
More about TagametSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
More about Alka-SeltzerSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate)?
Worth itNot sureNot worth it