Compare Tagamet vs. Alka-Seltzer

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tagamet (cimetidine)

Prescription or OTC
Treats heartburn.

Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.

4.6/ 7 average rating with 632 reviewsforTagamet
Relieves heartburn, headache, and body pains.

Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) gives quick relief for headache, body pains, and upset tummies, but might be hard to swallow if you don't like the taste or fizz.

5.4/ 7 average rating with 1055 reviewsforAlka-Seltzer
Upsides
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
  • Works great if you have an upset stomach and a headache or body pain at the same time.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
Downsides
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Because it has aspirin in it, it increases the risk of bleeding, especially if you take any other blood thinning medicine.
  • Can't be used by people with allergy to aspirin.
  • You may not like the taste or fizz.
Used for
Dosage forms
  • Pill
  • Liquid
  • Chewable tablet
  • Effervescent tablet
Price
Lowest price near you
$15.99
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Reviews
632 
63%
think this treatment is worth it
36%
think this treatment works well
12%
think this treatment is a hassle

Have you used Tagamet (cimetidine)?

Leave a review
1055 
81%
think this treatment is worth it
52%
think this treatment works well
8%
think this treatment is a hassle

Have you used Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate)?

Leave a review
Side effects
The Tagamet (cimetidine) FDA package insert doesn’t have numbers about how common side effects are.
The Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Confusion

    Elderly

    ...and 3 more risk factors

  • Chronic lung problems

    Asthma

    ...and 2 more risk factors

  • Clostridium difficile associated diarrhea

    Taking antibiotics

See more detailed risks and warnings
  • High blood sodium levels

    Current kidney disease

    ...and 2 more risk factors

  • May worsen heart or kidney problems

    Congestive heart failure (CHF)

    ...and 3 more risk factors

  • Brain damage or death from Reye's Syndrome

    Children 18 years or younger recovering from viral infections

  • Stomach Bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Serious allergic reactions

    Asthma

    ...and 4 more risk factors

See more detailed risks and warnings