Compare Tagamet vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.


(Aluminum / Magnesium / Simethicone)

Relieves heartburn and acid tummy. Tagamet (Cimetidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Relieves heartburn and acid tummy. Maalox (Aluminum / Magnesium / Simethicone) gives quick relief for heartburn, gas, and bloating. It may not be as effective or last as long as alternative antacids though.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Tagamet (Cimetidine)
of people say Tagamet (Cimetidine) is worth it
say it works well
say it's a big hassle
631 reviews
Reviews for Maalox (Aluminum / Magnesium / Simethicone)
+5% vs. Tagamet (Cimetidine)
6% vs. Tagamet (Cimetidine)
+3% vs. Tagamet (Cimetidine)
212 reviews
Side effects
  • Headache 2%
More Tagamet side effects »

We haven’t found good data for Maalox side effects.

FDA side effect reports for Maalox »
How it works
Tagamet (Cimetidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Maalox (Aluminum / Magnesium / Simethicone) is a combination medicine for stomach trouble. Aluminum and magnesium are antacids that relieve heartburn and acid tummy (indigestion). Simethicone relieves gas and bloating.
Type of medication
Acid reducer
Histamine blocker
Prescription or OTC
Available as
  • Pill
  • Liquid
  • Chewable tablet
  • Liquid
Used for (click to learn more)
Risk factors for serious side effects
    • Current kidney disease
    • Current liver disease
    • Age 50 or older
    • Current severe illness
      • Autoimmune disease
      • HIV or AIDS
      • Organ transplant
      • People without a spleen
      Detailed Tagamet (Cimetidine) risks & warnings »
      • Age 65 or older
        • Current kidney disease
          Detailed Maalox (Aluminum / Magnesium / Simethicone) risks & warnings »
          Pregnancy category
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          NFDA pregnancy category (Unknown)

          The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

          See the FDA package insert
          No specific alcohol-related info.No specific alcohol-related info.
          No specific food-related info.
          • Take 1-3 hours after a meal.
          Kidneys and liver
          • People with kidney disease may need to take a lower dose.
          • Tagamet (Cimetidine) can cause states of intense confusion. This is usually reversible when you stop taking Tagamet (Cimetidine). If you have kidney problems, you may need a different dose to prevent this increased risk for side effects. However, stopping Tagamet (Cimetidine) completely may be necessary.
          • People with kidney disease may need to avoid Maalox. Ask your doctor.
          • If you have kidney disease Maalox (Aluminum / Magnesium / Simethicone) can build up in your blood. This may can cause toxic levels of aluminum or magnesium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Maalox (Aluminum / Magnesium / Simethicone); a different antacid would be better for you.
          No specific sex-related info.No specific sex-related info.
          No specific sleep-related info.No specific sleep-related info.
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          • Most people can take Cimetidine without any noticeable day-to-day side effects.
          • Cimetidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Works really fast.
          • Available over the counter without a prescription.
          • Cheap.
          Downsides and risks
          • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Cimetidine.
          • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Cimetidine (H2 blockers).
          • Has more drug interactions than zantac and pepcid.
          • Although rare, Cimetidine can cause large breasts or impotence for men who need to use high doses for 6 months or more. It's reversible though and should go away when you stop or if you change medication.
          • Doesn't last very long.
          • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
          • Some people don't care for the taste.
          Tips from our pharmacists for people taking the medication
          • Works best if you take it with a full glass of water.
          • Starts working in one hour.
          • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
          • People with kidney disease may need to take a lower dose.
          • Tell your doctor all of the medications that you use before taking Cimetidine to avoid drug interactions.
          • Take 1-3 hours after a meal.
          • Take 1-2 hours apart from other medication that you take by mouth.
          • Tell your doctor if you have severe diarrhea or constipation.
          • People with kidney disease may need to avoid Maalox. Ask your doctor.
          Learn more
          More about TagametSide effectsReviews & ratingsAlternativesFDA package insert
          More about MaaloxSide effectsReviews & ratingsAlternativesFDA package insert