Compare Tagamet vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tagamet (cimetidine)

Prescription or OTC

Zantac 75 (ranitidine)

Prescription or OTC
Treats heartburn.

Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.

4.6/ 7 average rating with 632 reviewsforTagamet
Relieves heartburn and stomach ulcers.

Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.

5.1/ 7 average rating with 1062 reviewsforZantac
Upsides
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
Downsides
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
Price
Lowest price near you
$15.99
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Reviews
632 
63%
think this treatment is worth it
36%
think this treatment works well
12%
think this treatment is a hassle

Have you used Tagamet (cimetidine)?

Leave a review
1062 
72%
think this treatment is worth it
44%
think this treatment works well
7%
think this treatment is a hassle

Have you used Zantac 75 (ranitidine)?

Leave a review
Side effects
The Tagamet (cimetidine) FDA package insert doesn’t have numbers about how common side effects are.
The Zantac 75 (ranitidine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Confusion

    Elderly

    ...and 3 more risk factors

  • Chronic lung problems

    Asthma

    ...and 2 more risk factors

  • Clostridium difficile associated diarrhea

    Taking antibiotics

See more detailed risks and warnings
  • Confusion

    Aged 60 years or older

    ...and 2 more risk factors

  • Acute porphyria

    Acute Porphyria

  • Chronic lung problems

    Asthma

    ...and 2 more risk factors

See more detailed risks and warnings