Compare Tagamet vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tagamet
(cimetidine)

Zantac 75
(ranitidine)

Treats heartburn. Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.Relieves heartburn and stomach ulcers. Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.
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Coupons for Tagamet
Best available price for 60 (400mg) tablets of cimetidine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.64Tagamet
Reviews for Tagamet
63%
of people (All ages) say Tagamet is worth it
36%
say it works well
12%
say it's a big hassle
632 reviews
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
Reviews for Zantac
72%
-9% worse vs. Tagamet
44%
-8% worse vs. Tagamet
7%
-5% worse vs. Tagamet
1062 reviews
Have you used Zantac 75 (ranitidine)?
Worth itNot sureNot worth it
Side effects
TagametZantac
  • Headache 2%
More Tagamet side effects »

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »
How it works
TagametZantac
Tagamet (cimetidine) reduces acid production in your stomach.Zantac 75 (ranitidine) reduces the production of acid by blocking a chemical from acting on the acid-producing cells in your stomach.
Type of medication
TagametZantac
Prescription or OTCPrescription or OTC
Available as
TagametZantac
  • Pill
  • Liquid
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
Used for
TagametZantac
Risk factors for serious side effects
TagametZantac
  • Elderly
  • Kidney problems
  • Liver problems
  • Dementia
  • Asthma
Detailed Tagamet (cimetidine) risks & warnings »
  • Aged 60 years or older
  • Kidney conditions
  • Liver conditions
  • Acute Porphyria
  • Asthma
Detailed Zantac 75 (ranitidine) risks & warnings »
Pregnancy
Interactions
TagametZantac
No interactions related info.
  • Zantac 75 (ranitidine) can interact with certain prescription and over-the-counter medications. Let your doctor or pharmacist know about the medicines you are currently taking.
Alcohol
TagametZantac
No alcohol related info.
  • The syrup product may contain up to 7.5% of alcohol.
Kidneys and liver
TagametZantac
  • Tagamet (cimetidine) can cause confusion if you have kidney or liver problems, dementia, or if you are over 60 years old. Talk to your doctor or pharmacist about alternative medicines if you have any of these conditions.
  • May not be the best option if you are elderly or have kidney or liver problems.
No kidneys and liver related info.
Upsides and benefits
TagametZantac
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
Downsides and risks
TagametZantac
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
Tips from our pharmacists for people taking the medication
TagametZantac
  • Take 30 minutes before eating for maximum heartburn relief.
  • Talk to your doctor if you don't see any improvement after 2 weeks.
  • Talk to your doctor if you end up using this medicine more than 2 times a week.
  • Let your doctor or pharmacist know about any other medicines or supplements that you are taking because Tagamet (cimetidine) can interfere with how a lot of other medicines work.
  • To prevent a heartburn attack, take Zantac 75 (ranitidine) 30 minutes before eating.
  • Works within 30 to 60 minutes. Relief lasts up to 12 hours.
  • Do not use Zantac 75 (ranitidine) for more than 14 days. Talk to your doctor if your symptoms do not improve after 2 weeks of using the over-the-counter product, as this may indicate a more serious problem.
  • The syrup product may contain up to 7.5% of alcohol.
  • Speak to your doctor or pharmacist about lifestyle and dietary changes that can help prevent heartburn.
Learn more
More about TagametSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zantac 75 (ranitidine)?
Worth itNot sureNot worth it