Compare Tegretol vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tegretol
(Carbamazepine)

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.48Tegretol
Reviews for Tegretol (Carbamazepine)
56%
of people (All ages) say Tegretol (Carbamazepine) is worth it
43%
say it works well
23%
say it's a big hassle
Have you used Tegretol (Carbamazepine)?
Worth itNot sureNot worth it
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
-10% worse vs. Tegretol (Carbamazepine)
40%
-3% worse vs. Tegretol (Carbamazepine)
27%
-4% worse vs. Tegretol (Carbamazepine)
Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?
Worth itNot sureNot worth it
Side effects
TegretolDepakote
  • Dizziness 32%
  • Drowsiness 19%
  • Nausea 18%
  • Vomiting 15%
  • Lack of muscle coordination 15%
  • Constipation 5%
  • Itching 6%
  • Dry mouth 5%
  • Muscle weakness 4%
  • Rash 3%
More Tegretol side effects »
  • Nausea 7%
  • Drowsiness 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Muscle weakness 3%
  • Abdominal pain 1%
  • Indigestion 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
How it works
TegretolDepakote
Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
TegretolDepakote
Prescription only
Prescription only
Available as
TegretolDepakote
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for
TegretolDepakote
Risk factors for serious side effects
TegretolDepakote
  • People also taking Depakote
  • Asian ancestry
    • History of depression
    • European, Chinese, or Japanese ancestry
      • Age 65 years or older
      • Stopping Tegretol (Carbamazepine) suddenly
      Detailed Tegretol (Carbamazepine) risks & warnings »
        • Children under age 2
        • History of metabolic disorders
          • History of depression
            • History of metabolic disorders
            • People also taking Topamax
            • People also taking Topamax
              • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
              Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
              Pregnancy

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Interactions
              TegretolDepakote
              • Interacts with many other medicines and supplements.
              No interactions related info.
              Food
              TegretolDepakote
              No food related info.
              • Take with food to avoid upset stomach.
              Kidneys and liver
              TegretolDepakote
              No kidneys and liver related info.
              • Can cause liver damage, so it's probably not safe if you already have liver problems.
              Weight
              TegretolDepakote
              No weight related info.
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • May cause hair loss and weight gain.
              Upsides and benefits
              TegretolDepakote
              • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
              • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
              • May be helpful in stabilizing mood for people with bipolar disorder.
              • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
              • One of the first-line options to stabilize mood for people with bipolar disorder.
              • Helpful in preventing frequent migraine headaches.
              Downsides and risks
              TegretolDepakote
              • Interacts with many other medicines and supplements.
              • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
              • Can cause blurry vision, dizziness, and upset stomach.
              • Not safe to use if you're pregnant.
              • Requires routine blood tests to see how the medicine is affecting your body.
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • Can cause liver damage, so it's probably not safe if you already have liver problems.
              • Not safe to use if you're pregnant.
              • Requires routine blood tests to see how the medicine is affecting your body.
              Tips from our pharmacists for people taking the medication
              TegretolDepakote
              • For the first week, avoid activities that require you to be alert.
              • Report skin rashes or blistering immediately.
              • Don't use if pregnant.
              • Requires routine blood tests.
              • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
              • Takes up to 5 weeks to feel full effects on mood.
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Requires routine blood tests.
              • Take with food to avoid upset stomach.
              • May cause hair loss and weight gain.
              • Different versions of Depakote have different dosing. Be careful.
              • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
              • Takes 3 to 4 weeks to feel full effects on mood.
              Learn more
              More about TegretolSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Tegretol (Carbamazepine)?
              Worth itNot sureNot worth it
              More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?
              Worth itNot sureNot worth it