Compare Tegretol vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tegretol
(carbamazepine)

Depacon
(valproate, valproic acid, or divalproex)

Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.48Tegretol
Reviews for Tegretol
56%
of people (All ages) say Tegretol is worth it
43%
say it works well
23%
say it's a big hassle
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
Reviews for Depakote
46%
+10% better vs. Tegretol
40%
+3% better vs. Tegretol
27%
+4% better vs. Tegretol
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
Side effects
TegretolDepakote
  • Dizziness 32%
  • Somnolence 19%
  • Nausea 18%
  • Vomiting 15%
  • Ataxia 15%
  • Constipation 5%
  • Pruritus 6%
  • Dry Mouth 5%
  • Asthenia 4%
  • Rash 3%
More Tegretol side effects »
  • Nausea 7%
  • Somnolence 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Asthenia 3%
  • Abdominal Pain 1%
  • Dyspepsia 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
How it works
TegretolDepakote
Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
TegretolDepakote
Prescription onlyPrescription only
Available as
TegretolDepakote
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for
TegretolDepakote
Risk factors for serious side effects
TegretolDepakote
  • People also taking Depakote
  • Asian ancestry
  • History of depression
  • European, Chinese, or Japanese ancestry
  • Age 65 years or older
Detailed Tegretol (carbamazepine) risks & warnings »
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
TegretolDepakote
  • Interacts with many other medicines and supplements.
No interactions related info.
Food
TegretolDepakote
No food related info.
  • Take with food to avoid upset stomach.
Kidneys and liver
TegretolDepakote
No kidneys and liver related info.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
Weight
TegretolDepakote
No weight related info.
  • May cause hair loss and weight gain.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
Upsides and benefits
TegretolDepakote
  • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
  • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
  • May be helpful in stabilizing mood for people with bipolar disorder.
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
Downsides and risks
TegretolDepakote
  • Interacts with many other medicines and supplements.
  • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
  • Can cause blurry vision, dizziness, and upset stomach.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Tips from our pharmacists for people taking the medication
TegretolDepakote
  • For the first week, avoid activities that require you to be alert.
  • Report skin rashes or blistering immediately.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes up to 5 weeks to feel full effects on mood.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
Learn more
More about TegretolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it