Compare Tegretol vs. Zonegran

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tegretol
(carbamazepine)

Zonegran
(zonisamide)

Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.Controls partial seizures. Zonegran (zonisamide) is used with other medicines to help control partial seizures. It can't be used by itself.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Tegretol
Best available price for 60 (200mg) tablets of tegretol
Coupons for Zonegran
Best available price for 60 (100mg) capsules of zonisamide
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.48Tegretol
Reviews for Tegretol
56%
of people (All ages) say Tegretol is worth it
43%
say it works well
23%
say it's a big hassle
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zonegran (zonisamide)?
Worth itNot sureNot worth it
Side effects
TegretolZonegran
  • Dizziness 32%
  • Drowsiness 19%
  • Nausea 18%
  • Vomiting 15%
  • Lack of muscle coordination 15%
  • Constipation 5%
  • Itching 6%
  • Dry mouth 5%
  • Muscle weakness 4%
  • Rash 3%
More Tegretol side effects »
  • Sleepiness 10%
  • Loss of appetite 7%
  • Dizziness 6%
  • Headache 2%
  • Nausea 3%
  • Agitation or irritability 5%
  • Fatigue 2%
  • Tiredness 2%
  • Trouble sleeping 3%
  • Low mood disorder 3%
More Zonegran side effects »
How it works
TegretolZonegran
Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.Zonegran (zonisamide) is a sulfonamide. It's not exactly clear how it controls seizures, but it stops nerves from sending signals that can cause seizures.
Type of medication
TegretolZonegran
Prescription onlyPrescription only
Available as
TegretolZonegran
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
  • Pill
Used for
TegretolZonegran
Risk factors for serious side effects
TegretolZonegran
  • People also taking Depakote
  • Asian ancestry
  • History of depression
  • European, Chinese, or Japanese ancestry
  • Age 65 years or older
Detailed Tegretol (carbamazepine) risks & warnings »
  • Allergy to sulfonamides such as Septra or Bactrim
  • Under age 18
  • Taking other medicines to control seizures
  • Diarrhea
  • Kidney disease
Detailed Zonegran (zonisamide) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
TegretolZonegran
  • Interacts with many other medicines and supplements.
No interactions related info.
Alcohol
TegretolZonegran
No alcohol related info.
  • Be very careful drinking alcohol or taking medicines for pain or anxiety while taking Zonegran (zonisamide) because your breathing can become dangerously slow.
Food
TegretolZonegran
No food related info.
  • You can take Zonegran (zonisamide) with or without food.
Kidneys and liver
TegretolZonegran
No kidneys and liver related info.
  • Rarely, Zonegran (zonisamide) can cause changes to the acid balance in your blood. If not treated in time, it can cause kidney stones, or weaken your bones and make them likely to fracture. Your doctor might do regular blood tests to make sure you're healthy.
  • Zonegran (zonisamide) can cause kidney stones; so you have to make sure you drink plenty of liquids.
Pain
TegretolZonegran
No pain related info.
  • If you're allergic to sulfa medicines, don’t take Zonegran (zonisamide), since you might have a severe allergic reaction. Talk to your doctor or go to the emergency room right away if you notice a skin rash, high fever, or severe pain in your stomach.
Upsides and benefits
TegretolZonegran
  • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
  • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
  • May be helpful in stabilizing mood for people with bipolar disorder.
  • Available in generic.
  • Can be given once a day, so it's easier to remember.
  • You can take Zonegran (zonisamide) with or without food.
Downsides and risks
TegretolZonegran
  • Interacts with many other medicines and supplements.
  • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
  • Can cause blurry vision, dizziness, and upset stomach.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Zonegran (zonisamide) has to be used with other medicines to help control your seizures. It's not used by itself.
  • Zonegran (zonisamide) is only approved in people age 16 or older.
  • Zonegran (zonisamide) can cause kidney stones; so you have to make sure you drink plenty of liquids.
  • Zonegran (zonisamide) can weaken your bones. Talk to your doctor about how to keep your bones strong.
  • Other medicines used to control seizures can interact with Zonegran (zonisamide), so your doctor might have to change the dosing of your medications.
Tips from our pharmacists for people taking the medication
TegretolZonegran
  • For the first week, avoid activities that require you to be alert.
  • Report skin rashes or blistering immediately.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes up to 5 weeks to feel full effects on mood.
  • Don't drive or do anything requiring concentration until you know how Zonegran (zonisamide) affects you since it can make you sleepy.
  • You're more likely to get overheated while taking Zonegran (zonisamide). Make sure you drink plenty of liquids, don't exercise too hard, and don't stay out in the sun if it's hot out.
  • Don't stop taking Zonegran (zonisamide) suddenly without talking to your doctor, as your seizures can get worse.
  • Be very careful drinking alcohol or taking medicines for pain or anxiety while taking Zonegran (zonisamide) because your breathing can become dangerously slow.
Learn more
More about TegretolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
More about ZonegranSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zonegran (zonisamide)?
Worth itNot sureNot worth it