Compare Tenex vs. Propranolol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tenex
(Guanfacine)

Inderal
(Propranolol)

Treats ADHD and lowers blood pressure. Tenex (Guanfacine) can be used to treat both blood pressure and ADHD, but it's not recommended as a first-line treatment for either problem.Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.
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Reviews & ratings
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Have you used Tenex (Guanfacine)?
Worth itNot sureNot worth it
Reviews for Inderal (Propranolol)
62%
13% vs. Tenex (Guanfacine)
58%
+8% vs. Tenex (Guanfacine)
17%
17% vs. Tenex (Guanfacine)
Have you used Inderal (Propranolol)?
Worth itNot sureNot worth it
Side effects
TenexPropranolol
  • Drowsiness 31%
  • Fatigue 8%
  • Dizziness 7%
  • Headache 5%
More Tenex side effects »
  • Dizziness 5%
  • Fatigue 4%
More Propranolol side effects »
How it works
TenexPropranolol
Tenex (Guanfacine) is a centrally-acting alpha agonist medication. It lowers blood pressure by slowing down the heart rate and relaxing the blood vessels. It's not clear how Tenex (Guanfacine) works in ADHD, but it's used when stimulants haven't worked or can't be used in people.Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
TenexPropranolol
Antihypertensive
Alpha agonist
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
TenexPropranolol
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
TenexPropranolol
Risk factors for serious side effects
TenexPropranolol
  • Taking other medications that cause sedation or sleepiness
  • Stopping Tenex (Guanfacine) suddenly to treat high blood pressure
Detailed Tenex (Guanfacine) risks & warnings »
  • Suddenly stopping Inderal (Propranolol)
    • Major surgery requiring anesthesia
    • Diabetes
      • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
        Detailed Inderal (Propranolol) risks & warnings »
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        TenexPropranolol
        • Limit the amount of alcohol you drink while taking this.
        No alcohol related info.
        Sleep
        TenexPropranolol
        • You can feel sleepy the first few times you take it, or when your dose is increased. Don't drive or do anything that requires concentration until you know how the medication affects your body.
        • People report having sleepiness or sedation while on Tenex (Guanfacine). You're at higher risk for this if you're taking other medications that have similar effects. Don't drive or do anything that requires concentration until you know how Tenex (Guanfacine) affects you.
        No sleep related info.
        Upsides and benefits
        TenexPropranolol
        • The same medication treats two different things, high blood pressure and attention deficit hyperactivity disorder (ADHD).
        • It's not a "controlled medication".
        • Used to control ADHD when stimulant medications haven't worked or can't be used due to other medical problems.
        • Available as a generic medication, so it should be more affordable than other options.
        • A first-choice treatment to prevent chest pain (angina).
        • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
        • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
        Downsides and risks
        TenexPropranolol
        • Doesn't control ADHD as well as stimulants do, so it's used as a second-line medication.
        • Not a preferred drug to control blood pressure.
        • Can't be stopped suddenly, especially for blood pressure, since the blood pressure can dramatically increase.
        • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
        • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
        • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
        • Can hide symptoms of low blood sugar if you're diabetic.
        • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
        Tips from our pharmacists for people taking the medication
        TenexPropranolol
        • Don't stop taking Tenex (Guanfacine) without talking to your doctor first.
        • Limit the amount of alcohol you drink while taking this.
        • Drink plenty of liquids and don't get overheated while taking Tenex (Guanfacine).
        • You can feel sleepy the first few times you take it, or when your dose is increased. Don't drive or do anything that requires concentration until you know how the medication affects your body.
        • Can take up to 2 weeks for the maximum effect.
        • Can cause dizziness in the first few days.
        • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • Can cause insomnia and fatigue.
        • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
        • Don't stop taking this medicine suddenly.
        Learn more
        More about TenexSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Tenex (Guanfacine)?
        Worth itNot sureNot worth it
        More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Inderal (Propranolol)?
        Worth itNot sureNot worth it