Compare Tenex vs. Topamax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tenex
(guanfacine)

Qudexy Xr
(topiramate)

Treats ADHD and lowers blood pressure. Tenex (Guanfacine) can be used to treat both blood pressure and ADHD, but it's not recommended as a first-line treatment for either problem.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.
Reviews & ratings
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Have you used Tenex (guanfacine)?
Worth itNot sureNot worth it
Reviews for Topamax
52%
+28% better vs. Tenex
50%
+10% better vs. Tenex
36%
+36% better vs. Tenex
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
Side effects
TenexTopamax
  • Dry Mouth 1%
  • Dizziness 2%
  • Any side effect 3%
  • Asthenia 2%
  • Somnolence 13%
  • Impotence 3%
  • Constipation 5%
More Tenex side effects »
  • Upper respiratory tract infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Rhinitis 5%
  • Paresthesia 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
How it works
TenexTopamax
Tenex (Guanfacine) is a centrally-acting alpha agonist medication. It lowers blood pressure by slowing down the heart rate and relaxing the blood vessels. It's not clear how Tenex (Guanfacine) works in ADHD, but it's used when stimulants haven't worked or can't be used in people.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.
Type of medication
TenexTopamax
Prescription onlyPrescription only
Available as
TenexTopamax
  • Pill
  • Extended release
  • Pill
  • Extended release capsule
Used for
TenexTopamax
Risk factors for serious side effects
TenexTopamax
  • Taking other medications that cause sedation or sleepiness
  • Stopping Tenex (Guanfacine) suddenly to treat high blood pressure
Detailed Tenex (guanfacine) risks & warnings »
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
TenexTopamax
  • Limit the amount of alcohol you drink while taking this.
No alcohol related info.
Kidneys and liver
TenexTopamax
No kidneys and liver related info.
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • A few people will get kidney stones.
Sleep
TenexTopamax
  • People report having sleepiness or sedation while on Tenex (Guanfacine). You're at higher risk for this if you're taking other medications that have similar effects. Don't drive or do anything that requires concentration until you know how Tenex (Guanfacine) affects you.
  • You can feel sleepy the first few times you take it, or when your dose is increased. Don't drive or do anything that requires concentration until you know how the medication affects your body.
No sleep related info.
Weight
TenexTopamax
No weight related info.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
Upsides and benefits
TenexTopamax
  • The same medication treats two different things, high blood pressure and attention deficit hyperactivity disorder (ADHD).
  • It's not a "controlled medication".
  • Used to control ADHD when stimulant medications haven't worked or can't be used due to other medical problems.
  • Available as a generic medication, so it should be more affordable than other options.
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
Downsides and risks
TenexTopamax
  • Doesn't control ADHD as well as stimulants do, so it's used as a second-line medication.
  • Not a preferred drug to control blood pressure.
  • Can't be stopped suddenly, especially for blood pressure, since the blood pressure can dramatically increase.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
TenexTopamax
  • Don't stop taking Tenex (Guanfacine) without talking to your doctor first.
  • Limit the amount of alcohol you drink while taking this.
  • Drink plenty of liquids and don't get overheated while taking Tenex (Guanfacine).
  • You can feel sleepy the first few times you take it, or when your dose is increased. Don't drive or do anything that requires concentration until you know how the medication affects your body.
  • Can take up to 2 weeks for the maximum effect.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
Learn more
More about TenexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tenex (guanfacine)?
Worth itNot sureNot worth it
More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it