Compare Tenex vs. Topamax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tenex (Guanfacine)

Prescription only

Topamax (topiramate)

Prescription only
Treats ADHD and lowers blood pressure.

Tenex (Guanfacine) can be used to treat both blood pressure and ADHD, but it's not recommended as a first-line treatment for either problem.

Prevents seizures and migraine headaches.

Topamax (topiramate) is very effective at preventing many types of seizures and migraines, but it can cause several severe side effects that can lead to stopping the medication.

3.3/ 5 average rating with 56 reviewsforTopamax
Upsides
  • The same medication treats two different things, high blood pressure and attention deficit hyperactivity disorder (ADHD).
  • It's not a "controlled medication".
  • Used to control ADHD when stimulant medications haven't worked or can't be used due to other medical problems.
  • Available as a generic medication, so it should be more affordable than other options.
  • Can lower your number of seizures and also prevent migraine headaches. This medicine can be used on its own or with other antiepileptic medicines to lower the frequency of seizures.
  • Doesn't need routine blood tests like similar medications.
  • Available in short-acting and long-acting forms.
  • Comes as a generic, so it's relatively cheap.
Downsides
  • Doesn't control ADHD as well as stimulants do, so it's used as a second-line medication.
  • Not a preferred drug to control blood pressure.
  • Can't be stopped suddenly, especially for blood pressure, since the blood pressure can dramatically increase.
  • Can cause many severe side effects. People starting Topamax (topiramate) need to be monitored for these effects as soon as they start treatment.
  • This medicine can take 4 to 6 weeks for the full effects of this medication to kick in, especially for people taking it for migraines.
  • Children taking Topamax (topiramate) for long periods of time need to have their dose adjusted by their pediatrician as they grow.
  • At higher doses (ie. 400 mg/day), children may experience difficulty with concentration/attention, fever, flushing, and confusion.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
  • Extended release capsule
Price
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Reviews
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56 reviews so far
52%
saidit'sworth it
50%
saiditworked well
36%
saidit'sa big hassle

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Side effects
7possible side effects
  • Dry Mouth
    10%
  • Somnolence
    10%
  • Headache
    7%
  • Fatigue
    5%
  • Any side effect
    5%
  • Asthenia
    3%
  • Dizziness
    2%
See more detailed side effects
39possible side effects
  • Sleepiness
    26%
  • Loss of appetite
    24%
  • Fatigue
    16%
  • Injury
    14%
  • Nervousness
    14%
  • Personality disorder (behavior problems)
    11%
  • Difficulty with concentration/attention
    10%
  • Weight loss
    9%
  • Aggressive reaction
    9%
  • Abnormal gait
    8%
  • Purpura
    8%
  • Difficulty sleeping
    8%
  • Viral infection
    7%
  • Impaired coordination
    6%
  • Nausea
    6%
  • Increased saliva
    6%
  • Muscle spasm
    5%
  • Constipation
    5%
  • Difficulty with memory
    5%
  • Pneumonia
    5%
  • Dizziness
    4%
  • Speech disorders/ related speech problems
    4%
  • Nose bleed
    4%
  • Confusion
    4%
  • Urinary incontinence
    4%
  • Stomach flu
    3%
  • Psychomotor slowing
    3%
  • Skin disorder
    3%
  • Allergic reaction
    2%
  • Abnormal reflexes
    2%
  • Thirst
    2%
  • Pussing
    2%
  • Hair loss
    2%
  • Dermatitis
    2%
  • Increased hair growth
    2%
  • Red skin rash
    2%
  • Eye abnormality
    2%
  • Abnormal vision
    2%
  • Leukopenia
    2%
See more detailed side effects
Risks and risk factors
  • Sedation
    • Taking other medications that cause sedation or sleepiness
  • Rebound high blood pressure
    • Stopping Tenex (Guanfacine) suddenly to treat high blood pressure
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • History of depression
  • Fever and inability to sweat
    • Children
  • Mental and cognitive changes
    • History of metabolic disorders
    • People also taking Depakote
  • Kidney stones
    • Low-carb diet
    • Dehydration
    • Drug interactions
  • Vision problems
  • Withdrawal seizures
    • Stopping Topamax (topiramate) suddenly
See more detailed risks and warnings