Compare Testim vs. Depo-Testosterone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Testim
(testosterone gel)

Depo-Testosterone
(testosterone cypionate injection)

Treats low testosterone. This testosterone gel comes in convenient daily doses, but you have to be careful about skin-to-skin contact with other people.Treats low testosterone. This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.
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Coupons for Testim
Best available price for 150 (50mg of 1%) packets of testosterone
Coupons for Depo-Testosterone
Best available price for 1 (1ml of 200mg/ml) vial of testosterone-cypionate
Reviews & ratings
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Have you used Testim (testosterone gel)?
Worth itNot sureNot worth it
Reviews for Depo-Testosterone
49%
+51% better vs. Testim
32%
+68% better vs. Testim
17%
+17% better vs. Testim
100 reviews
Have you used Depo-Testosterone (testosterone cypionate injection)?
Worth itNot sureNot worth it
Side effects
TestimDepo-Testosterone
  • Increase in hematocrit (≥ 58%) 1%
  • Hematocrit/hemoglobin increased 2%
  • Increase in hemoglobin (≥ 19 g/dl) 1%
More Testim side effects »

The Depo-Testosterone FDA package insert doesn’t have numbers about how common side effects are.

More about Depo-Testosterone side effects »
How it works
TestimDepo-Testosterone
Testosterone gel works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.The testosterone injection works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
TestimDepo-Testosterone
Prescription onlyPrescription only
Available as
TestimDepo-Testosterone
  • Cream, gel, or ointment
  • Injection
Used for
TestimDepo-Testosterone
  • Low Testosterone
  • Low Testosterone
Risk factors for serious side effects
TestimDepo-Testosterone
    Coming soon.
    • Male
    • Enlarged prostate (benign prostatic hypertrophy)
    • Taking high doses of Depo-Testosterone (Testosterone Cypionate Injection)
    • Heart, liver or kidney disease
    Detailed Depo-Testosterone (testosterone cypionate injection) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Kidneys and liver
    TestimDepo-Testosterone
    No kidneys and liver related info.
    • There have been reports of people on Depo-Testosterone (Testosterone Cypionate Injection) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This can happen if you are unable to move around or have cancer. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
    Upsides and benefits
    TestimDepo-Testosterone
    • You apply it to your shoulders and upper arms like a lotion, so it's easy to use.
    • Available in individual daily doses, so it's more convenient than some alternatives.
    • A first-choice treatment for low testosterone in men and delayed puberty in boys.
    • Available in generic.
    • Only has to be given once every 2 to 4 weeks.
    • The shot can be done at home.
    Downsides and risks
    TestimDepo-Testosterone
    • Not available in generic form, so it can be more expensive.
    • You have to let the skin dry after you've put on testosterone gel, and you have to wear clothes over the area to prevent the medication from spreading onto other people.
    • You have to wait at least 2 hours after applying testosterone gel before you can swim or bathe, otherwise your body won't absorb the full amount of the medication.
    • Only available as a shot.
    • Has to be given by someone else since it has to be injected into your buttocks.
    Tips from our pharmacists for people taking the medication
    TestimDepo-Testosterone
    • Use the entire contents of one tube each day and apply to your shoulders and upper arms. Don't put it anywhere else.
    • Don't swim or bathe for at least 2 hours after you apply testosterone gel.
    • Cover the area with clothing as soon as it's dry so you don't spread it to other people, and wash your hands with soap and water.
    • If you think you'll have skin-to-skin contact at the area where you've placed testosterone gel, wash that area with soap and water then dry.
    • Your doctor will show you how to inject this correctly.
    • Can cause nausea, vomiting and headache.
    • Can cause increased acne and changes in sex drive.
    • Keep this medication locked up and away from children since it's a controlled substance.
    Learn more
    More about TestimSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Testim (testosterone gel)?
    Worth itNot sureNot worth it
    More about Depo-TestosteroneSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Depo-Testosterone (testosterone cypionate injection)?
    Worth itNot sureNot worth it