Compare Theraflu Daytime Severe Cold and Cough vs. Alka-Seltzer Plus Day Cold and Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Theraflu Daytime Severe Cold And Cough
(Acetaminophen / Dextromethorphan / Phenylephrine)

Alka-Seltzer Plus Day Cold And Flu
(Acetaminophen / Dextromethorphan / Phenylephrine)

Relieves cold and flu symptoms. Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is good for treating multiple cold and flu symptoms, but it's more medicine than you need if you only have one symptom.Relieves cold and flu symptoms. Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.
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Reviews & ratings
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Have you used Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine)?
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Have you used Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine)?
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Side effects
Theraflu Daytime Severe Cold and CoughAlka-Seltzer Plus Day Cold and Flu

We haven’t found good data for Theraflu Daytime Severe Cold and Cough side effects.

FDA side effect reports for Theraflu Daytime Severe Cold and Cough »

We haven’t found good data for Alka-Seltzer Plus Day Cold and Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Day Cold and Flu »
How it works
Theraflu Daytime Severe Cold and CoughAlka-Seltzer Plus Day Cold and Flu
Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Theraflu Daytime Severe Cold and CoughAlka-Seltzer Plus Day Cold and Flu
Pain reliever
Acetaminophen (APAP)
Cough suppressantDecongestantOver-the-counter
Pain reliever
Acetaminophen (APAP)
Cough suppressantDecongestantOver-the-counter
Available as
Theraflu Daytime Severe Cold and CoughAlka-Seltzer Plus Day Cold and Flu
  • Powder
  • Pill
Used for (click to learn more)
Theraflu Daytime Severe Cold and CoughAlka-Seltzer Plus Day Cold and Flu
Risk factors for serious side effects
Theraflu Daytime Severe Cold and CoughAlka-Seltzer Plus Day Cold and Flu
  • Drinking more than 3 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
  • History of high blood pressure
  • Taking MAO inhibitors
  • Using other medications that affect serotonin
  • History of phenylketonuria (PKU)
  • Women of childbearing age
Detailed Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) risks & warnings »
Pregnancy category
Theraflu Daytime Severe Cold and CoughAlka-Seltzer Plus Day Cold and Flu
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Upsides and benefits
Theraflu Daytime Severe Cold and CoughAlka-Seltzer Plus Day Cold and Flu
  • Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold and flu symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • Since you're taking this with water, it can help you stay hydrated.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
Downsides and risks
Theraflu Daytime Severe Cold and CoughAlka-Seltzer Plus Day Cold and Flu
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
Tips from our pharmacists for people taking the medication
Theraflu Daytime Severe Cold and CoughAlka-Seltzer Plus Day Cold and Flu
  • Starts working in about 30 minutes.
  • Dissolve 1 packet in a cup of hot water and use every 4 hours as needed. Don't use more than 5 packets in 24 hours.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
Learn more
More about Theraflu Daytime Severe Cold and CoughSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine)?
Worth itNot sureNot worth it
More about Alka-Seltzer Plus Day Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Alka-Seltzer Plus Day Cold And Flu (Acetaminophen / Dextromethorphan / Phenylephrine)?
Worth itNot sureNot worth it