Compare Theraflu Daytime Severe Cold And Cough vs. Phenylephrine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine)

Over-the-counter

Sudafed Pe (Phenylephrine)

Prescription or OTC
Relieves cold and flu symptoms.

Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is good for treating multiple cold and flu symptoms, but it's more medicine than you need if you only have one symptom.

Clears your sinuses.

Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.

4.2/ 7 average rating with 164 reviewsforPhenylephrine
Upsides
  • Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold and flu symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • Since you're taking this with water, it can help you stay hydrated.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Works to clear nasal congestion and helps you breathe better.
  • Helpful in relieving congestion-related headaches.
  • Has fewer side effects than other decongestants like pseudoephedrine.
  • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
Downsides
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
  • You shouldn't use it if you have high blood pressure.
  • Can make your heart race or make you feel anxious and restless.
  • Shouldn't use it before you want to sleep.
  • Not as effective after using it for 4 days in a row.
Used for
Dosage forms
  • Powder
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
Price
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Lowest price near you
$17.3
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Reviews
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164 
44%
think this treatment is worth it
24%
think this treatment works well
10%
think this treatment is a hassle

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Side effects
The Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
The Sudafed Pe (Phenylephrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Liver damage

    Drinking more than 3 alcoholic beverages a day

    ...and 2 more risk factors

  • Chronic cough from an infection

    History of chronic obstructive pulmonary disease (COPD)

    ...and 1 more risk factors

  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Brain damage from too much phenylalanine

    History of phenylketonuria (PKU)

  • Harm to unborn babies

    Women of childbearing age

See more detailed risks and warnings
  • High blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Harm to fetus

    Women of childbearing age

See more detailed risks and warnings