Compare Theraflu Daytime Severe Cold And Cough vs. Phenylephrine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Theraflu Daytime Severe Cold And Cough
(acetaminophen / dextromethorphan / phenylephrine)

Sudafed Pe
(phenylephrine)

Relieves cold and flu symptoms. Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is good for treating multiple cold and flu symptoms, but it's more medicine than you need if you only have one symptom.Clears your sinuses. Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Phenylephrine
Best available price for 2 (2ml of 2.5%) eye droppers of phenylephrine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Theraflu Daytime Severe Cold And Cough (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
Reviews for Phenylephrine
44%
+23% better vs. Theraflu Daytime Severe Cold And Cough
24%
+9% better vs. Theraflu Daytime Severe Cold And Cough
10%
-7% worse vs. Theraflu Daytime Severe Cold And Cough
164 reviews
Have you used Sudafed Pe (phenylephrine)?
Worth itNot sureNot worth it
Side effects
Theraflu Daytime Severe Cold And CoughPhenylephrine

We haven’t found good data for Theraflu Daytime Severe Cold And Cough side effects.

FDA side effect reports for Theraflu Daytime Severe Cold And Cough »

We haven’t found good data for Phenylephrine side effects.

FDA side effect reports for Phenylephrine »
How it works
Theraflu Daytime Severe Cold And CoughPhenylephrine
Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.Sudafed Pe (Phenylephrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.
Type of medication
Theraflu Daytime Severe Cold And CoughPhenylephrine
Over-the-counterPrescription or OTC
Available as
Theraflu Daytime Severe Cold And CoughPhenylephrine
  • Powder
  • Pill
  • Nasal spray
  • Eye drops
  • Suppository
Used for
Theraflu Daytime Severe Cold And CoughPhenylephrine
Risk factors for serious side effects
Theraflu Daytime Severe Cold And CoughPhenylephrine
  • Drinking more than 3 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
Detailed Theraflu Daytime Severe Cold And Cough (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of heart problems
  • Age 65 years or older
  • Women of childbearing age
Detailed Sudafed Pe (phenylephrine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
Theraflu Daytime Severe Cold And CoughPhenylephrine
  • Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) contains aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, don't use this product.
No food related info.
Kidneys and liver
Theraflu Daytime Severe Cold And CoughPhenylephrine
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
No kidneys and liver related info.
Pain
Theraflu Daytime Severe Cold And CoughPhenylephrine
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
No pain related info.
Upsides and benefits
Theraflu Daytime Severe Cold And CoughPhenylephrine
  • Theraflu Daytime Severe Cold And Cough (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold and flu symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • Since you're taking this with water, it can help you stay hydrated.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • Works to clear nasal congestion and helps you breathe better.
  • Helpful in relieving congestion-related headaches.
  • Has fewer side effects than other decongestants like pseudoephedrine.
  • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
Downsides and risks
Theraflu Daytime Severe Cold And CoughPhenylephrine
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
  • You shouldn't use it if you have high blood pressure.
  • Can make your heart race or make you feel anxious and restless.
  • Shouldn't use it before you want to sleep.
  • Not as effective after using it for 4 days in a row.
Tips from our pharmacists for people taking the medication
Theraflu Daytime Severe Cold And CoughPhenylephrine
  • Starts working in about 30 minutes.
  • Dissolve 1 packet in a cup of hot water and use every 4 hours as needed. Don't use more than 5 packets in 24 hours.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Starts working in 30 minutes.
  • Phenylephrine can make you restless, so don't take it too close to bedtime.
  • It's in other cold and flu combination medicines. Read labels closely so you don't accidentally double up and take too much of it in a day.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
Learn more
More about Theraflu Daytime Severe Cold And CoughSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Theraflu Daytime Severe Cold And Cough (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
More about PhenylephrineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Sudafed Pe (phenylephrine)?
Worth itNot sureNot worth it