Compare thiothixene vs. thioridazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Navane
(thiothixene)

Mellaril
(thioridazine)

Treats schizophrenia. Navane (thiothixene) isn't a first choice for treating schizophrenia because of the side effects, but it is cheaper than other medicines.Treats schizophrenia. Taking Mellaril (thioridazine) is one of many options to treat schizophrenia if other medicines haven't worked, but there are some side effects which can be dangerous.
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Coupons for thiothixene
Best available price for 30 (5mg) capsules of thiothixene
Reviews & ratings
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Have you used Navane (thiothixene)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Mellaril (thioridazine)?
Worth itNot sureNot worth it
Side effects
thiothixenethioridazine

The thiothixene FDA package insert doesn’t have numbers about how common side effects are.

More about thiothixene side effects »

The thioridazine FDA package insert doesn’t have numbers about how common side effects are.

More about thioridazine side effects »
How it works
thiothixenethioridazine
Navane (thiothixene) is a typical antipsychotic. It works by lowering levels of dopamine in the brain. It's believed that schizophrenia might be caused by the brain being too sensitive to changes in dopamine.Mellaril (thioridazine) is a typical antipsychotic that lowers levels of dopamine in the brain. In schizophrenia, it's believed the brain produces too much dopamine.
Type of medication
thiothixenethioridazine
Prescription onlyPrescription only
Available as
thiothixenethioridazine
  • Pill
  • Pill
Used for
thiothixenethioridazine
Risk factors for serious side effects
thiothixenethioridazine
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol, or taking opioids, benzodiazepines, or sleeping medicines
Detailed Navane (thiothixene) risks & warnings »
  • History of heartbeat problems
  • Taking medicines for depression
  • Taking beta blockers
  • People older than 65 years with dementia and psychosis
  • Long-term use of Mellaril (thioridazine)
Detailed Mellaril (thioridazine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
thiothixenethioridazine
  • Don't drink alcohol while taking Navane (thiothixene).
  • Don't drink alcohol while taking Mellaril (thioridazine).
Food
thiothixenethioridazine
  • Take Navane (thiothixene) with food so you don't get an upset stomach.
  • You can take Mellaril (thioridazine) with or without food. Take it with food if you get an upset stomach.
Sleep
thiothixenethioridazine
  • Navane (thiothixene) can make you sleepy and unable to focus, so don't drive or do anything requiring concentration for a few hours after taking it until you know how Navane (thiothixene) affects your concentration. This can be worse if you drink alcohol or take medicines that can make you sleepy, such as opioids for pain, benzodiazepines for anxiety, or medicines to help you sleep.
  • Mellaril (thioridazine) can make you feel sleepy the first few days that you take it, and you might be more likely to fall and hurt yourself. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Mellaril (thioridazine) affects you. Be very careful getting up if you've been sitting or lying down for a while, and brace yourself and sit down if you do feel dizzy.
Weight
thiothixenethioridazine
  • Side effects include weight gain and high blood sugar.
No weight related info.
Upsides and benefits
thiothixenethioridazine
  • Navane (thiothixene) is available in generic.
  • Navane (thiothixene) is less likely to make you sleepy.
  • Available in generic.
  • Compared to other similar medicines, Mellaril (thioridazine) is less likely to cause problems controlling your movements.
Downsides and risks
thiothixenethioridazine
  • Side effects include weight gain and high blood sugar.
  • Navane (thiothixene) can cause low blood pressure, which can cause fainting or falls if you’re not careful.
  • Smoking tobacco can make Navane (thiothixene) work poorly.
  • Mellaril (thioridazine) is only recommended for schizophrenia if other medicines haven't worked because the side effects can be very dangerous.
  • You have to take Mellaril (thioridazine) numerous times a day which can make it hard to remember.
  • Mellaril (thioridazine) can interfere with your heartbeat, so your doctor might have you do annual tests with your heart to make sure it's healthy.
Tips from our pharmacists for people taking the medication
thiothixenethioridazine
  • Don't drive or do anything requiring concentration until you know how Navane (thiothixene) affects you.
  • You might not notice any changes in your behavior until you've taken Navane (thiothixene) for at least 4 weeks.
  • Navane (thiothixene) can cause low blood pressure. Be very careful getting up if you've been sitting or lying down for a while since you can feel faint.
  • Navane (thiothixene) can make it hard to control your body temperature. Be careful exercising, especially in the heat, and dress warmly if it's cold.
  • Take Navane (thiothixene) with food so you don't get an upset stomach.
  • Don't drink alcohol while taking Navane (thiothixene).
  • Don't stop taking Mellaril (thioridazine) suddenly without talking to your doctor, even if you start to feel well.
  • You can take Mellaril (thioridazine) with or without food. Take it with food if you get an upset stomach.
  • If you've missed a dose of Mellaril (thioridazine), take it as soon as you remember. But if it's time for your next dose, just take your normal amount and don't take extra medicine to make up for the missed dose.
  • Don't drive or do anything requiring concentration until you know how Mellaril (thioridazine) affects you.
  • Don't drink alcohol while taking Mellaril (thioridazine).
Learn more
More about thiothixeneSide effectsAlternativesFDA package insert
Have you used Navane (thiothixene)?
Worth itNot sureNot worth it
More about thioridazineSide effectsAlternativesFDA package insert
Have you used Mellaril (thioridazine)?
Worth itNot sureNot worth it