Compare thiothixene vs. trifluoperazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Navane
(thiothixene)

Stelazine
(trifluoperazine)

Treats schizophrenia. Navane (thiothixene) isn't a first choice for treating schizophrenia because of the side effects, but it is cheaper than other medicines.Treats anxiety and schizophrenia. Stelazine (trifluoperazine) can be used to treat schizophrenia, but you might have trouble controlling your movements.
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Coupons for thiothixene
Best available price for 30 (5mg) capsules of thiothixene
Coupons for trifluoperazine
Best available price for 30 (5mg) tablets of trifluoperazine
Reviews & ratings
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Have you used Navane (thiothixene)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Stelazine (trifluoperazine)?
Worth itNot sureNot worth it
Side effects
thiothixenetrifluoperazine

The thiothixene FDA package insert doesn’t have numbers about how common side effects are.

More about thiothixene side effects »

The trifluoperazine FDA package insert doesn’t have numbers about how common side effects are.

More about trifluoperazine side effects »
How it works
thiothixenetrifluoperazine
Navane (thiothixene) is a typical antipsychotic. It works by lowering levels of dopamine in the brain. It's believed that schizophrenia might be caused by the brain being too sensitive to changes in dopamine.Stelazine (trifluoperazine) is a first generation (typical) antipsychotic. It works in schizophrenia by making the brain less sensitive to changes in dopamine, which helps regulate your mood.
Type of medication
thiothixenetrifluoperazine
Prescription onlyPrescription only
Available as
thiothixenetrifluoperazine
  • Pill
  • Pill
Used for
thiothixenetrifluoperazine
Risk factors for serious side effects
thiothixenetrifluoperazine
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol, or taking opioids, benzodiazepines, or sleeping medicines
Detailed Navane (thiothixene) risks & warnings »
  • People age 65 and older with dementia and psychosis
  • Women age 65 and older
  • Taking antipsychotic medications
  • History of low white or red blood cell counts
Detailed Stelazine (trifluoperazine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
thiothixenetrifluoperazine
  • Don't drink alcohol while taking Navane (thiothixene).
  • Don't drink alcohol while taking Stelazine (trifluoperazine).
Food
thiothixenetrifluoperazine
  • Take Navane (thiothixene) with food so you don't get an upset stomach.
No food related info.
Sleep
thiothixenetrifluoperazine
  • Navane (thiothixene) can make you sleepy and unable to focus, so don't drive or do anything requiring concentration for a few hours after taking it until you know how Navane (thiothixene) affects your concentration. This can be worse if you drink alcohol or take medicines that can make you sleepy, such as opioids for pain, benzodiazepines for anxiety, or medicines to help you sleep.
No sleep related info.
Weight
thiothixenetrifluoperazine
  • Side effects include weight gain and high blood sugar.
No weight related info.
Upsides and benefits
thiothixenetrifluoperazine
  • Navane (thiothixene) is available in generic.
  • Navane (thiothixene) is less likely to make you sleepy.
  • Stelazine (trifluoperazine) is one of the recommended medicines for schizophrenia.
  • It’s approved in children age 6 and older.
  • Available in generic.
  • Compared to other similar medicines, you're less likely to feel dehydrated or have problems with your heart with Stelazine (trifluoperazine).
Downsides and risks
thiothixenetrifluoperazine
  • Side effects include weight gain and high blood sugar.
  • Navane (thiothixene) can cause low blood pressure, which can cause fainting or falls if you’re not careful.
  • Smoking tobacco can make Navane (thiothixene) work poorly.
  • If you take Stelazine (trifluoperazine) for more than 12 weeks or are taking high doses of Stelazine (trifluoperazine), you’re at a higher risk for being unable to control your movements.
  • Stelazine (trifluoperazine) can cause agitation and trouble sleeping. These symptoms can sometimes disappear, or there are other treatments you can take to help.
Tips from our pharmacists for people taking the medication
thiothixenetrifluoperazine
  • Don't drive or do anything requiring concentration until you know how Navane (thiothixene) affects you.
  • You might not notice any changes in your behavior until you've taken Navane (thiothixene) for at least 4 weeks.
  • Navane (thiothixene) can cause low blood pressure. Be very careful getting up if you've been sitting or lying down for a while since you can feel faint.
  • Navane (thiothixene) can make it hard to control your body temperature. Be careful exercising, especially in the heat, and dress warmly if it's cold.
  • Take Navane (thiothixene) with food so you don't get an upset stomach.
  • Don't drink alcohol while taking Navane (thiothixene).
  • Stelazine (trifluoperazine) can make you more sensitive to changes in temperature. If it's hot out, drink plenty of liquids, don't exercise too hard, and protect yourself from the sun. If it's cold, dress warm and don't stay outside too long.
  • Stelazine (trifluoperazine) can make you feel sleepy for the first few days. Don't drive or do anything requiring concentration until you know how it affects you.
  • Don't drink alcohol while taking Stelazine (trifluoperazine).
  • You might feel dizzy or faint the first few days you take Stelazine (trifluoperazine). Be very careful getting up if you've been sitting or lying down for a while.
  • If you want to stop taking Stelazine (trifluoperazine) and you've been taking it for at least a few months, talk to your doctor first.
Learn more
More about thiothixeneSide effectsAlternativesFDA package insert
Have you used Navane (thiothixene)?
Worth itNot sureNot worth it
More about trifluoperazineSide effectsAlternativesFDA package insert
Have you used Stelazine (trifluoperazine)?
Worth itNot sureNot worth it