Compare Tofranil vs. Celexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Improves your mood and stops bedwetting in children.

Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

Improves mood.

Celexa (citalopram) is good for treating depression and anxiety. Side effects are less likely to happen compared to other antidepressants; however, it is not the best choice for people with heart or liver problems.

3.7/ 5 average rating with 520 reviewsforCelexa
Upsides
  • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil (imipramine hydrochloride) is usually taken only once a day.
  • Available in 3 different strengths.
  • Effectively relieves depression symptoms.
  • This medicine is not as drowsy as other antidepressants.
  • Available as a generic, which is cheaper.
Downsides
  • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
  • Can cause sexual side effects like decreased sex drive, difficulties with orgasm or ejaculation, and minor weight gain (1 to 5 pounds).
  • Celexa (citalopram) may not be a good option if you have heart or liver problems.
  • Like most antidepressants, Celexa (citalopram) can increase risk of suicidal thoughts and behavior in people younger than 24 years.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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520 reviews so far
61%
saidit'sworth it
51%
saiditworked well
16%
saidit'sa big hassle

Have you used Celexa (citalopram)?

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Side effects
The Tofranil (imipramine hydrochloride) FDA package insert doesn’t have numbers about how common side effects are.
25possible side effects
  • Nausea
    21%
  • Dry mouth
    20%
  • Drowsiness
    18%
  • Difficulty sleeping
    15%
  • Increased sweating
    11%
  • Tremor
    8%
  • Diarrhea
    8%
  • Abnormal ejaculation
    6%
  • Indigestion
    5%
  • Fatigue
    5%
  • Upper airway infection
    5%
  • Stuffy nose
    5%
  • Vomiting
    4%
  • Anxiety
    4%
  • Anorexia
    4%
  • Abdominal pain
    3%
  • Agitation
    3%
  • Menstrual cramps
    3%
  • Sinus infection
    3%
  • Erection difficulties
    3%
  • Fever
    2%
  • Joint pain
    2%
  • Muscle pain
    2%
  • Decreased sex drive
    2%
  • Yawning
    2%
See more detailed side effects
Risks and risk factors
  • Higher risk of suicide
    • Under age 24
  • Possible bipolar disorder
  • Heart problems
    • History of heart disease
    • Overactive thyroid
  • Blood pressure changes
    • High blood pressure
  • Higher risk of seizures
    • History of seizures
  • Changes in metabolism
    • History of diabetes
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
  • Bipolar disorder
    • History of bipolar disorder
    • At risk for bipolar disorder
  • Withdrawal
    • Stopping Celexa (citalopram) abruptly
  • Lower maximum dose in some people
    • Higher dose
    • History of heart problems
    • History of liver problems
    • 60 years or older
  • Increased bleeding
    • Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
  • Sexual side effects
See more detailed risks and warnings