Compare Tofranil vs. Celexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tofranil
(Imipramine Hydrochloride)

Celexa
(Citalopram)

Coming soon.Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.
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Reviews & ratings
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Have you used Tofranil (Imipramine Hydrochloride)?
Worth itNot sureNot worth it
Reviews for Celexa (Citalopram)
61%
+61% better vs. Tofranil (Imipramine Hydrochloride)
51%
+51% better vs. Tofranil (Imipramine Hydrochloride)
16%
-16% worse vs. Tofranil (Imipramine Hydrochloride)
520 reviews
Have you used Celexa (Citalopram)?
Worth itNot sureNot worth it
Side effects
TofranilCelexa

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »
  • Nausea 7%
  • Dry mouth 6%
  • Drowsiness 8%
  • Sleep difficulty 1%
  • Sweating increased 2%
  • Diarrhea 3%
  • Tremor 2%
  • Ejaculation disorder 5%
  • Inflammation inside the nose 1%
  • Indigestion 1%
More Celexa side effects »
How it works
TofranilCelexa
Coming soon.Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
TofranilCelexa
Prescription only
Available as
TofranilCelexa
  • Pill
  • Pill
  • Oral solution
Used for
TofranilCelexa
  • Depression Nocturnal Enuresis
Risk factors for serious side effects
TofranilCelexa
Coming soon.
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Stopping Celexa (Citalopram) suddenly
  • Higher dose
  • History of heart problems
  • History of liver problems
  • Older age
  • Taking other blood-thinning drugs
    Detailed Celexa (Citalopram) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    TofranilCelexa
    No food related info.
    • Take with food to avoid upset stomach.
    Kidneys and liver
    TofranilCelexa
    No kidneys and liver related info.
    • Not a good option for you if you have heart or liver problems.
    Sex
    TofranilCelexa
    No sex related info.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    Weight
    TofranilCelexa
    No weight related info.
    • Can cause minor weight gain (1 to 5 pounds).
    Upsides and benefits
    TofranilCelexa
    Coming soon
    • Effective at relieving depression and anxiety symptoms.
    • Causes less sleepiness compared to other antidepressants.
    • Six out of ten people who use an antidepressant for the first time find that it works for them.
    Downsides and risks
    TofranilCelexa
    Coming soon
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Can cause minor weight gain (1 to 5 pounds).
    • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
    • Not a good option for you if you have heart or liver problems.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    Tips from our pharmacists for people taking the medication
    TofranilCelexa
    Coming soon
    • Take with food to avoid upset stomach.
    • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
    • Stop taking it slowly to avoid getting withdrawal symptoms.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    Learn more
    More about TofranilSide effectsReviews & ratingsFDA package insert
    Have you used Tofranil (Imipramine Hydrochloride)?
    Worth itNot sureNot worth it
    More about CelexaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Celexa (Citalopram)?
    Worth itNot sureNot worth it