Compare Tofranil vs. Neurontin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tofranil
(Imipramine Hydrochloride)

Neurontin
(Gabapentin)

Coming soon.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.
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Reviews & ratings
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Have you used Tofranil (Imipramine Hydrochloride)?
Worth itNot sureNot worth it
Reviews for Neurontin (Gabapentin)
57%
+57% better vs. Tofranil (Imipramine Hydrochloride)
40%
+40% better vs. Tofranil (Imipramine Hydrochloride)
19%
-19% worse vs. Tofranil (Imipramine Hydrochloride)
620 reviews
Have you used Neurontin (Gabapentin)?
Worth itNot sureNot worth it
Side effects
TofranilNeurontin

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
How it works
TofranilNeurontin
Coming soon.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
TofranilNeurontin
Prescription only
Available as
TofranilNeurontin
  • Pill
  • Pill
  • Oral solution
Used for
TofranilNeurontin
  • Depression Nocturnal Enuresis
Risk factors for serious side effects
TofranilNeurontin
Coming soon.
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (Gabapentin) risks & warnings »
      Pregnancy

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      TofranilNeurontin
      No food related info.
      • Take the extended-release tablet with food.
      Pain
      TofranilNeurontin
      No pain related info.
      • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
      Sleep
      TofranilNeurontin
      No sleep related info.
      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
      Upsides and benefits
      TofranilNeurontin
      Coming soon
      • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
      • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
      • It's available as a generic, so it's less expensive than similar medications.
      Downsides and risks
      TofranilNeurontin
      Coming soon
      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
      • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
      Tips from our pharmacists for people taking the medication
      TofranilNeurontin
      Coming soon
      • Side effects are common, but usually manageable.
      • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
      • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
      • Take the extended-release tablet with food.
      • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
      Learn more
      More about TofranilSide effectsReviews & ratingsFDA package insert
      Have you used Tofranil (Imipramine Hydrochloride)?
      Worth itNot sureNot worth it
      More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Neurontin (Gabapentin)?
      Worth itNot sureNot worth it