Compare Tofranil vs. Neurontin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tofranil
(imipramine hydrochloride)

Neurontin
(gabapentin)

Improves your mood and stops bedwetting in children. Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.
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Coupons for Tofranil
Best available price for 30 (25mg) tablets of imipramine hydrochloride
Coupons for Neurontin
Best available price for 90 (300mg) capsules of gabapentin
Reviews & ratings
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Reviews for Tofranil (imipramine hydrochloride)
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of people (All ages) say Tofranil (imipramine hydrochloride) is worth it
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say it works well
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say it's a big hassle
Have you used Tofranil (imipramine hydrochloride)?
Worth itNot sureNot worth it
Reviews for Neurontin (gabapentin)
57%
+57% better vs. Tofranil (imipramine hydrochloride)
40%
+40% better vs. Tofranil (imipramine hydrochloride)
19%
-19% worse vs. Tofranil (imipramine hydrochloride)
620 reviews
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
Side effects
TofranilNeurontin

The Tofranil FDA package insert doesn’t have numbers about how common side effects are.

More about Tofranil side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
How it works
TofranilNeurontin
Tofranil (imipramine hydrochloride) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood. It's not known exactly how Tofranil (imipramine hydrochloride) treats bedwetting.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
TofranilNeurontin
Prescription only
Prescription only
Available as
TofranilNeurontin
  • Pill
  • Pill
  • Oral solution
Used for
TofranilNeurontin
Risk factors for serious side effects
TofranilNeurontin
  • Under age 24
  • History of heart disease
  • Overactive thyroid
  • High blood pressure
  • History of seizures
Detailed Tofranil (imipramine hydrochloride) risks & warnings »
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed Neurontin (gabapentin) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
TofranilNeurontin
  • Don't drink alcohol while taking Tofranil (imipramine hydrochloride).
No alcohol related info.
Food
TofranilNeurontin
No food related info.
  • Take the extended-release tablet with food.
Pain
TofranilNeurontin
No pain related info.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
Sleep
TofranilNeurontin
  • Tofranil (imipramine hydrochloride) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
Weight
TofranilNeurontin
  • Compared to other medicines for depression, Tofranil (imipramine hydrochloride) can make you more likely to gain weight and have changes in blood sugar. If you have diabetes, your doctor might need to change the doses of your medications to make sure your blood sugar stays controlled. Talk to your doctor to see if you should take another medicine besides Tofranil (imipramine hydrochloride).
No weight related info.
Upsides and benefits
TofranilNeurontin
  • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil (imipramine hydrochloride) is usually taken only once a day.
  • Available in 3 different strengths.
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
Downsides and risks
TofranilNeurontin
  • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
Tips from our pharmacists for people taking the medication
TofranilNeurontin
  • You might need to take Tofranil (imipramine hydrochloride) for a few weeks before you notice any changes in your mood.
  • Don't drink alcohol while taking Tofranil (imipramine hydrochloride).
  • If you miss your bedtime dose, skip it and take your regular dose the next evening. Don't take extra medicine to make up for the missed dose.
  • You might be more sensitive to the sun while taking Tofranil (imipramine hydrochloride). Make sure to drink plenty of liquids, wear sunscreen, or cover your skin if you'll be out in the sun.
  • Tofranil (imipramine hydrochloride) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
  • Don't stop taking Tofranil (imipramine hydrochloride) without talking to your doctor first.
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
Learn more
More about TofranilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tofranil (imipramine hydrochloride)?
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More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it