Compare Tofranil vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(imipramine hydrochloride)


Coming soon.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Prices and coupon for 30 (25mg) tablets of imipramine hydrochloride
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Prices and coupon for 30 (50mg) tablets of trazodone
Reviews & ratings
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Have you used Tofranil (imipramine hydrochloride)?
Worth itNot sureNot worth it
Reviews for Oleptro (trazodone)
+73% better vs. Tofranil (imipramine hydrochloride)
+49% better vs. Tofranil (imipramine hydrochloride)
-24% worse vs. Tofranil (imipramine hydrochloride)
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Side effects

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Headache 6%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
How it works
Coming soon.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
Prescription only
Available as
  • Pill
  • Pill
  • Extended release
Used for
  • Depression Nocturnal Enuresis
Risk factors for serious side effects
Coming soon.
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
  • Drug interactions
    • Age 65 years or older
    • Alcohol
    • Taking other medicines that make you less alert
    Detailed Oleptro (trazodone) risks & warnings »

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Upsides and benefits
    Coming soon
    • Commonly used in lower doses to help treat sleep problems (insomnia).
    • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
    • Fewer sexual side effects than many other antidepressants.
    • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
    • Comes as a generic medication and is cheaper than many other sleep aides.
    • Six out of ten people who use an antidepressant for the first time find that it works for them.
    Downsides and risks
    Coming soon
    • Not as effective as other medications for depression.
    • More sedating than other antidepressants.
    • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
    • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    Tips from our pharmacists for people taking the medication
    Coming soon
    • Makes you sleepy. Take at bedtime.
    • Can cause temporary dry mouth and upset stomach.
    • Seek medical attention for unwanted, persistent erection.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    Learn more
    More about TofranilSide effectsReviews & ratingsFDA package insert
    Have you used Tofranil (imipramine hydrochloride)?
    Worth itNot sureNot worth it
    More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Oleptro (trazodone)?
    Worth itNot sureNot worth it