Compare Tofranil vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tofranil
(Imipramine Hydrochloride)

Pamelor
(Nortriptyline)

Coming soon.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Button Group. All currently active
Button Group. All currently active

Not enough reviews for this drug. Help someone out, leave a review!

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
TofranilPamelor

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
How it works
TofranilPamelor
Coming soon.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.
Type of medication
TofranilPamelor
Coming soon.
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Available as
TofranilPamelor
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
TofranilPamelor
  • Depression Nocturnal enuresis
Risk factors for serious side effects
TofranilPamelor
Coming soon.
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
  • Older age
  • Electrolyte imbalance
Detailed Pamelor (Nortriptyline) risks & warnings »
Pregnancy category
TofranilPamelor
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.
  • Take it with food and/or at bedtime to decrease the potential side effects.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.
  • Stopping Pamelor (Nortriptyline) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
TofranilPamelor
Coming soon.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Downsides and risks
TofranilPamelor
Coming soon.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Tips from our pharmacists for people taking the medication
TofranilPamelor
Coming soon.
  • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
  • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Learn more
More about TofranilSide effectsFDA package insert
More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert