Compare Tofranil vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Improves your mood and stops bedwetting in children.

Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

4.0/ 5 average rating with 19 reviewsforPamelor
Upsides
  • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil (imipramine hydrochloride) is usually taken only once a day.
  • Available in 3 different strengths.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Downsides
  • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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19 reviews so far
79%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

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Side effects
The Tofranil (imipramine hydrochloride) FDA package insert doesn’t have numbers about how common side effects are.
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of suicide
    • Under age 24
  • Possible bipolar disorder
  • Heart problems
    • History of heart disease
    • Overactive thyroid
  • Blood pressure changes
    • High blood pressure
  • Higher risk of seizures
    • History of seizures
  • Changes in metabolism
    • History of diabetes
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Low blood pressure
    • Age 65 years or older
  • Withdrawal
    • Stopping Pamelor (Nortriptyline) suddenly
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings