Compare Tofranil vs. Paxil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Improves your mood and stops bedwetting in children.

Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

Improves mood and anxiety.

Paxil (paroxetine) is effective for treating depression and anxiety, but causes more unwanted side-effects than other medicines that work like it.

3.4/ 5 average rating with 694 reviewsforPaxil
Upsides
  • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil (imipramine hydrochloride) is usually taken only once a day.
  • Available in 3 different strengths.
  • Available in a cheaper, generic form.
  • Is convenient and can take once a day.
Downsides
  • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
  • More likely to decrease your sexual appetite and delay or prevent ejaculation than other antidepressants.
  • Like most antidepressants, Paxil (paroxetine) has a high risk of suicidal thoughts and behavior when used in children and adolescents.
  • May not be appropriate for you if you are elderly or suffer from dementia.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release pill
  • Liquid
Price
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Reviews
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694 reviews so far
52%
saidit'sworth it
39%
saiditworked well
24%
saidit'sa big hassle

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Side effects
The Tofranil (imipramine hydrochloride) FDA package insert doesn’t have numbers about how common side effects are.
29possible side effects
  • Abnormal ejaculation
    28%
  • Nausea
    25%
  • Weakness
    22%
  • Drowsiness
    22%
  • Difficulty sleeping
    21%
  • Decreased sexual appetite
    12%
  • Dizziness
    11%
  • Sweating
    9%
  • Dry mouth
    9%
  • Diarrhea
    9%
  • Tremor
    9%
  • Female genital disorder
    9%
  • Decreased appetite
    8%
  • Nervousness
    8%
  • Constipation
    5%
  • Anxiety
    5%
  • Yawning
    5%
  • Painful period
    5%
  • Impotence
    5%
  • Indigestion
    4%
  • Gas
    4%
  • Muscle pain
    4%
  • Impaired concentration
    4%
  • Throat inflammation
    4%
  • Abnormal vision
    4%
  • Trauma
    3%
  • Agitation
    3%
  • Vomiting
    2%
  • Muscle twitching
    2%
See more detailed side effects
Risks and risk factors
  • Higher risk of suicide
    • Under age 24
  • Possible bipolar disorder
  • Heart problems
    • History of heart disease
    • Overactive thyroid
  • Blood pressure changes
    • High blood pressure
  • Higher risk of seizures
    • History of seizures
  • Changes in metabolism
    • History of diabetes
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • High levels of serotonin (Serotonin Syndrome)
    • Using other medications that affect serotonin levels
  • Withdrawal
    • Stopping Paxil (paroxetine) suddenly
  • Increased bleeding risk
    • Taking other blood-thinning drugs
  • Sexual dysfunction
See more detailed risks and warnings