Compare Tofranil vs. Paxil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tofranil
(Imipramine Hydrochloride)

Paxil
(Paroxetine)

Coming soon.Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.
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Reviews & ratings
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Have you used Tofranil (Imipramine Hydrochloride)?
Worth itNot sureNot worth it
Reviews for Paxil (Paroxetine)
52%
+52% better vs. Tofranil (Imipramine Hydrochloride)
39%
+39% better vs. Tofranil (Imipramine Hydrochloride)
24%
-24% worse vs. Tofranil (Imipramine Hydrochloride)
694 reviews
Have you used Paxil (Paroxetine)?
Worth itNot sureNot worth it
Side effects
TofranilPaxil

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »
  • Nausea 17%
  • Drowsiness 14%
  • Dry mouth 6%
  • Headache 1%
  • Muscle weakness 9%
  • Constipation 5%
  • Sleep difficulty 7%
  • Ejaculatory disturbance‡§ 13%
  • Dizziness 7%
  • Diarrhea 4%
More Paxil side effects »
How it works
TofranilPaxil
Coming soon.Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
TofranilPaxil
Prescription only
Available as
TofranilPaxil
  • Pill
  • Pill
  • Extended release tablet
  • Liquid
Used for
TofranilPaxil
  • Depression Nocturnal Enuresis
Risk factors for serious side effects
TofranilPaxil
Coming soon.
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Paxil (Paroxetine) suddenly
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
      Detailed Paxil (Paroxetine) risks & warnings »
      Pregnancy

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      TofranilPaxil
      No food related info.
      • Take with food to avoid upset stomach.
      Sleep
      TofranilPaxil
      No sleep related info.
      • It causes drowsiness, so it's good for people who have trouble sleeping.
      Weight
      TofranilPaxil
      No weight related info.
      • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
      • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
      Upsides and benefits
      TofranilPaxil
      Coming soon
      • Effective at relieving depression and anxiety symptoms.
      • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
      • It causes drowsiness, so it's good for people who have trouble sleeping.
      • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      TofranilPaxil
      Coming soon
      • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
      • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
      • Can harm an unborn child, so you can't take it if you're pregnant.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      TofranilPaxil
      Coming soon
      • Take with food to avoid upset stomach.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • The controlled-release (CR) tablet can cause less nausea than other forms.
      • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
      • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
      Learn more
      More about TofranilSide effectsReviews & ratingsFDA package insert
      Have you used Tofranil (Imipramine Hydrochloride)?
      Worth itNot sureNot worth it
      More about PaxilSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Paxil (Paroxetine)?
      Worth itNot sureNot worth it