Compare Tofranil vs. Prozac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tofranil
(imipramine hydrochloride)

Prozac
(fluoxetine)

Coming soon.Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.
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Coupons for Tofranil
Best available price for 30 (25mg) tablets of imipramine hydrochloride
Coupons for Prozac
Best available price for 30 (20mg) capsules of fluoxetine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Tofranil (imipramine hydrochloride)
Not enough review data. Review it!
of people (All ages) say Tofranil (imipramine hydrochloride) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Tofranil (imipramine hydrochloride)?
Worth itNot sureNot worth it
Reviews for Prozac (fluoxetine)
62%
+62% better vs. Tofranil (imipramine hydrochloride)
40%
+40% better vs. Tofranil (imipramine hydrochloride)
16%
-16% worse vs. Tofranil (imipramine hydrochloride)
1319 reviews
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
Side effects
TofranilProzac

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »
  • Nausea 13%
  • Headache 2%
  • Sleep difficulty 18%
  • Nervousness 5%
  • Drowsiness 7%
  • Anxiety 6%
  • Diarrhea 4%
  • Muscle weakness 5%
  • Loss of appetite 7%
  • Dizziness 3%
More Prozac side effects »
How it works
TofranilProzac
Coming soon.Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
TofranilProzac
Prescription only
Available as
TofranilProzac
  • Pill
  • Pill
  • Delayed release capsule
  • Liquid
Used for
TofranilProzac
  • Depression Nocturnal Enuresis
Risk factors for serious side effects
TofranilProzac
    Coming soon.
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • Stopping Prozac (Fluoxetine) suddenly
    • History of heart problems
    • History of liver problems
    Detailed Prozac (fluoxetine) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    TofranilProzac
    No food related info.
    • Take in the morning with food to avoid side effects.
    Sex
    TofranilProzac
    No sex related info.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    Upsides and benefits
    TofranilProzac
    Coming soon
    • Effective at relieving depression and anxiety symptoms.
    • Lowers relapse rates of depression and bulimia nervosa.
    • Causes less sleepiness than other antidepressants.
    • It's more energizing than other antidepressants, so it's good for people who have low energy.
    • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
    • Six out of ten people who use an antidepressant for the first time find that it works for them.
    Downsides and risks
    TofranilProzac
    Coming soon
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
    • More likely than other antidepressants to interact with other medications you're taking.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    Tips from our pharmacists for people taking the medication
    TofranilProzac
    Coming soon
    • Take in the morning with food to avoid side effects.
    • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
    • Stop taking it slowly to avoid getting withdrawal symptoms.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    Learn more
    More about TofranilSide effectsReviews & ratingsFDA package insert
    Have you used Tofranil (imipramine hydrochloride)?
    Worth itNot sureNot worth it
    More about ProzacSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Prozac (fluoxetine)?
    Worth itNot sureNot worth it