Compare Tofranil vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tofranil
(imipramine hydrochloride)

Remeron
(mirtazapine)

Coming soon.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Prices and coupon for 30 (25mg) tablets of imipramine hydrochloride
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Prices and coupon for 30 (15mg) tablets of mirtazapine
Reviews & ratings
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Have you used Tofranil (imipramine hydrochloride)?
Worth itNot sureNot worth it
Reviews for Remeron (mirtazapine)
45%
+45% better vs. Tofranil (imipramine hydrochloride)
39%
+39% better vs. Tofranil (imipramine hydrochloride)
26%
-26% worse vs. Tofranil (imipramine hydrochloride)
152 reviews
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it
Side effects
TofranilRemeron

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »
  • Drowsiness 36%
  • Dry mouth 10%
  • Increased appetite 15%
  • Constipation 6%
  • Weight gain 10%
  • Muscle weakness 3%
  • Dizziness 4%
  • Flu syndrome 2%
  • Abnormal dreams 3%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
TofranilRemeron
Coming soon.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
TofranilRemeron
Prescription only
Available as
TofranilRemeron
  • Pill
  • Pill
  • Dissolving tablet
Used for
TofranilRemeron
  • Depression Nocturnal Enuresis
Risk factors for serious side effects
TofranilRemeron
Coming soon.
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
  • Alcohol
  • Taking other medicines that make you less alert
      Detailed Remeron (mirtazapine) risks & warnings »
      Pregnancy

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Weight
      TofranilRemeron
      No weight related info.
      • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
      • Can increase appetite and weight.
      • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
      Upsides and benefits
      TofranilRemeron
      Coming soon
      • Effective at relieving some depression symptoms.
      • Starts to work more quickly than most antidepressants.
      • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
      • Good option for people who are underweight or frail, because it can help you gain weight.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      TofranilRemeron
      Coming soon
      • Not as effective as other medications for depression.
      • More sedating than other antidepressants.
      • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
      • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      TofranilRemeron
      Coming soon
      • Makes you sleepy. Take at bedtime.
      • Can increase appetite and weight.
      • Takes 8 to 12 weeks to see full effects on mood.
      • Stop taking slowly to avoid withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about TofranilSide effectsReviews & ratingsFDA package insert
      Have you used Tofranil (imipramine hydrochloride)?
      Worth itNot sureNot worth it
      More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Remeron (mirtazapine)?
      Worth itNot sureNot worth it