Compare Tofranil vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tofranil (imipramine hydrochloride)

Prescription only

Remeron (mirtazapine)

Prescription only
Improves your mood and stops bedwetting in children.

Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

Improves mood.

Remeron (mirtazapine) improves your mood and helps you sleep better, but can cause more weight gain than any other antidepressant.

4.5/ 7 average rating with 152 reviewsforRemeron
Upsides
  • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil (imipramine hydrochloride) is usually taken only once a day.
  • Available in 3 different strengths.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Can help you fall asleep if you have trouble sleeping.
  • Can also help relieve anxiety.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • Available as a generic.
Downsides
  • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
  • Makes you more tired than other antidepressants.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
Used for
Dosage forms
  • Pill
  • Pill
  • Dissolving tablet
Price
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$11.33
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$10
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Reviews
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152 
45%
think this treatment is worth it
39%
think this treatment works well
26%
think this treatment is a hassle

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Side effects
The Tofranil (imipramine hydrochloride) FDA package insert doesn’t have numbers about how common side effects are.
The Remeron (mirtazapine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Higher risk of suicide

    Under age 24

  • Heart problems

    History of heart disease

    ...and 1 more risk factors

  • Blood pressure changes

    High blood pressure

  • Higher risk of seizures

    History of seizures

  • Changes in metabolism

    History of diabetes

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Heart problems

    History of heart problems

    ...and 2 more risk factors

  • Driving impairment

    Alcohol

    ...and 1 more risk factors

See more detailed risks and warnings