Compare Tofranil vs. Viibryd

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tofranil
(Imipramine Hydrochloride)

Viibryd
(Vilazodone)

Coming soon.Treats depression. Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.
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Reviews & ratings
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Reviews for Viibryd (Vilazodone)
67%
+67% vs. Tofranil (Imipramine Hydrochloride)
59%
+59% vs. Tofranil (Imipramine Hydrochloride)
13%
13% vs. Tofranil (Imipramine Hydrochloride)
Side effects
TofranilViibryd

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »
  • Diarrhea 19%
  • Nausea 18%
  • Vomiting 4%
  • Dizziness 4%
  • Sleep difficulty 4%
  • Dry mouth 3%
  • Abnormal dreams 3%
  • Tingling sensation 2%
  • Fatigue 1%
  • Impotence 1%
More Viibryd side effects »
How it works
TofranilViibryd
Coming soon.Viibryd (Vilazodone) is an antidepressant that is both a selective serotonin reuptake inhibitor (SSRI) and a serotonin receptor agonist. It treats depression by adjusting the levels of serotonin in your brain.
Type of medication
TofranilViibryd
Coming soon.
Antidepressant
Partial serotonin receptor agonist
Prescription only
Available as
TofranilViibryd
  • Pill
  • Pill
Used for (click to learn more)
TofranilViibryd
  • Depression Nocturnal enuresis
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Tofranil (Imipramine Hydrochloride)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Viibryd (Vilazodone)
Risk factors for serious side effects
TofranilViibryd
Coming soon.
  • Age 18 years or younger
  • Taking Viibryd (Vilazodone) with MAOIs
  • Taking Viibryd (Vilazodone) with Zyvox or methylene blue
  • Taking Viibryd (Vilazodone) with other drugs that increase serotonin
  • Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
  • Women of childbearing age
  • History of glaucoma
  • History of bipolar disorder (mixed/mania)
Detailed Viibryd (Vilazodone) risks & warnings »
Pregnancy category
TofranilViibryd
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Food
No specific food-related info.
  • Take Viibryd (Vilazodone) with food at the same time every day.
Kidneys and liver
No specific kidneys and liver-related info.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
Sex
No specific sex-related info.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Sleep
No specific sleep-related info.
  • In some people, antidepressants like Viibryd (Vilazodone) can trigger a manic episode (increased energy, severe trouble sleeping, racing thoughts, reckless behavior, unusually grand ideas, excessive happiness/ irritability, talking faster or louder than usual). Let your doctor know if you've had any manic episodes in the past or were treated for bipolar disorder before taking Viibryd (Vilazodone).
Weight
No specific weight-related info.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Upsides and benefits
TofranilViibryd
Coming soon.
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Downsides and risks
TofranilViibryd
Coming soon.
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Tips from our pharmacists for people taking the medication
TofranilViibryd
Coming soon.
  • Take Viibryd (Vilazodone) with food at the same time every day.
  • Your dose will need to be increased slowly over the first 3 weeks to reduce feelings of upset stomach.
  • It can take 4 to 6 weeks to see the full effects, so continue taking it even if you start to feel better.
  • Stopping Viibryd (Vilazodone) suddenly can cause withdrawal symptoms, including anxiety, irritability, headache, and dizziness. Gradually lower your dose over a 1 to 2 week period before stopping it completely.
  • Call your doctor right away if you notice new or worsening symptoms of aggressive or violent behavior, panic attacks, or other unusual changes in behavior or mood.
Learn more
More about TofranilSide effectsFDA package insert
More about ViibrydSide effectsReviews & ratingsAlternativesFDA package insert