Compare Tofranil vs. Viibryd

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tofranil (imipramine hydrochloride)

Prescription only

Viibryd (Vilazodone)

Prescription only
Improves your mood and stops bedwetting in children.

Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

Treats depression.

Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.

5.4/ 7 average rating with 95 reviewsforViibryd
  • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil (imipramine hydrochloride) is usually taken only once a day.
  • Available in 3 different strengths.
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
  • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
The Tofranil (imipramine hydrochloride) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Diarrhea
  • Nausea
  • Dizziness
  • Dry mouth
  • Insomnia
  • Vomiting
  • Decreased libido
  • Abnormal dreams
  • Libido decreased
  • Fatigue
See more detailed side effects
Risks and warnings
  • Higher risk of suicide

    Under age 24

  • Heart problems

    History of heart disease

    ...and 1 more risk factors

  • Blood pressure changes

    High blood pressure

  • Higher risk of seizures

    History of seizures

  • Changes in metabolism

    History of diabetes

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 18 years or younger

  • Monoamine oxidase inhibitor (MAOI) interaction

    Taking Viibryd (Vilazodone) with MAOIs

    ...and 1 more risk factors

  • Serotonin syndrome

    Taking Viibryd (Vilazodone) with other drugs that increase serotonin

  • Abnormal bleeding

    Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting

  • Risk to fetus

    Women of childbearing age

  • Eye problems

    History of glaucoma

  • Activation of mania/hypomania

    History of bipolar disorder (mixed/mania)

See more detailed risks and warnings