Compare Tofranil vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(Imipramine Hydrochloride)


Coming soon.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
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Reviews & ratings
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Reviews for Zoloft (Sertraline)
+59% vs. Tofranil (Imipramine Hydrochloride)
+40% vs. Tofranil (Imipramine Hydrochloride)
15% vs. Tofranil (Imipramine Hydrochloride)
1299 reviews
Side effects

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »
How it works
Coming soon.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
Coming soon.
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Available as
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
  • Depression Nocturnal enuresis
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Tofranil (Imipramine Hydrochloride)

After 4 weeks using Start and Zoloft (Sertraline), here’s how much better people feel.

Risk factors for serious side effects
Coming soon.
  • Under 24 years old
  • Interactions with other medications
      • Stopping Zoloft (Sertraline) suddenly
      • Taking with blood-thinning drugs
      • Elderly
      • Taking with diuretic medications
      Detailed Zoloft (Sertraline) risks & warnings »
      Pregnancy category
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      No specific alcohol-related info.No specific alcohol-related info.
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      No specific sex-related info.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      No specific sleep-related info.
      • Causes less drowsiness than other antidepressants.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      Coming soon.
      • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
      • Causes less drowsiness than other antidepressants.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      Coming soon.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • More likely to cause diarrhea than other antidepressants.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      Coming soon.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • It interacts with St. John's Wort and Tryptophan.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about TofranilSide effectsFDA package insert
      More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert