Compare tolcapone vs. Azilect

Head-to-head comparisons of medication uses, side effects, ratings, and more.

tolcapone

Azilect
(rasagiline)

Treats Parkinson's disease. Taking Tasmar (tolcapone) is the next step to control Parkinson's disease when carbidopa/levodopa don't work as well, however you might be more likely to have liver damage.Treats Parkinson's disease. Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.
Reviews & ratings
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Have you used Tasmar (tolcapone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it
Side effects
tolcaponeAzilect
  • Urine discoloration 1%
  • Low blood pressure 1%
  • Stiffness 1%
  • Joint pain 1%
  • Problems with urination 1%
  • Neck pain or stiffness 1%
  • Burning sensation 2%
  • Nasal congestion 2%
  • Flu 1%
More tolcapone side effects »
  • Arthritis 1%
  • Bruising 2%
  • Weakness 2%
  • Neck pain 2%
  • Tingling or prickling sensation 1%
  • Dizziness 1%
  • Gum swelling 1%
  • Excessive bleeding 1%
  • Hernia 1%
  • Muscle weakness 1%
More Azilect side effects »
How it works
tolcaponeAzilect
Tasmar (tolcapone) is an enzyme inhibitor that stops levodopa from being broken down. It causes higher levodopa in the brain, which relieves the symptoms of Parkinson's disease.Azilect (rasagiline) is a monoamine oxidase inhibitor. It increases the amount of dopamine in the brain, which helps those with Parkinson's disease gain better control their movements.
Type of medication
tolcaponeAzilect
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
tolcaponeAzilect
  • Pill
  • Pill
Used for
tolcaponeAzilect
Risk factors for serious side effects
tolcaponeAzilect
  • Liver damage
  • Taking other medicines for Parkinson's disease
  • Taking antipsychotic medicines
Detailed Tasmar (tolcapone) risks & warnings »
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Azilect (rasagiline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
tolcaponeAzilect
  • Tasmar (tolcapone) can be taken with or without food.
No food related info.
Upsides and benefits
tolcaponeAzilect
  • Tasmar (tolcapone) is part of the medicines used as the most common next step to control Parkinson's disease when carbidopa/levodopa doesn't work as well.
  • Tasmar (tolcapone) is available as a generic.
  • Tasmar (tolcapone) can be taken with or without food.
  • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
  • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
  • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
Downsides and risks
tolcaponeAzilect
  • When you first start taking Tasmar (tolcapone), your doctor might have to change the dose a lot because of all the side effects.
  • Tasmar (tolcapone) will only slow the disease down; it is not a cure for Parkinson's disease.
  • Unlike Comtan, Tasmar (tolcapone) is more likely to damage your liver, so you might need regular blood tests for the first few months.
  • Tasmar (tolcapone) is not available as a combination pill with carbidopa/levodopa, unlike Comtan.
  • Tasmar (tolcapone) can cause dry mouth and changes in blood pressure. Changes in blood pressure can make you feel faint and more likely to fall.
  • It can cause unusual cravings and changes in behavior in some people.
Tips from our pharmacists for people taking the medication
tolcaponeAzilect
  • Tasmar (tolcapone) can make you dizzy if you've been sitting or lying down for a while. Be very careful when getting up.
  • Don't drive or do anything requiring concentration until you know how Tasmar (tolcapone) affects you.
  • Your urine might be colored dark orange or brown while taking Tasmar (tolcapone). This is normal.
  • You have to keep taking carbidopa/levodopa with Tasmar (tolcapone). Tasmar (tolcapone) won't work by itself to control your Parkinson's disease.
  • Talk to your doctor if you want to stop taking Tasmar (tolcapone). Stopping it suddenly can be very dangerous.
  • Azilect (rasagiline) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Watch how much cheese, soy sauce or smoked meats you eat. Eating too much of these foods while on Azilect (rasagiline) can cause an unsafe rise in blood pressure.
  • Azilect (rasagiline) can make you dizzy or lightheaded, especially when you suddenly stand up from sitting or laying down.
  • Don't stop taking Azilect (rasagiline) without talking to your doctor first. Stopping it suddenly can cause confusion, stiff muscles and a high fever.
  • Azilect (rasagiline) can prevent many medicines from working properly. Check with your doctor or pharmacist if the way you take your other medicines needs to be changed.
Learn more
More about tolcaponeSide effectsAlternativesFDA package insert
Have you used Tasmar (tolcapone)?
Worth itNot sureNot worth it
More about AzilectSide effectsAlternativesFDA package insert
Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it