Compare tolcapone vs. carbidopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tasmar (tolcapone)

Prescription only

Lodosyn (carbidopa)

Prescription only
Treats Parkinson's disease.

Taking Tasmar (tolcapone) is the next step to control Parkinson's disease when carbidopa/levodopa don't work as well, however you might be more likely to have liver damage.

Treats Parkinson's disease when given with levodopa.

Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.

Upsides
  • Tasmar (tolcapone) is part of the medicines used as the most common next step to control Parkinson's disease when carbidopa/levodopa doesn't work as well.
  • Tasmar (tolcapone) is available as a generic.
  • Tasmar (tolcapone) can be taken with or without food.
  • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
  • It is available in a combination pill with levodopa once you find the right dose that works for you.
Downsides
  • When you first start taking Tasmar (tolcapone), your doctor might have to change the dose a lot because of all the side effects.
  • Tasmar (tolcapone) will only slow the disease down; it is not a cure for Parkinson's disease.
  • Unlike Comtan, Tasmar (tolcapone) is more likely to damage your liver, so you might need regular blood tests for the first few months.
  • Tasmar (tolcapone) is not available as a combination pill with carbidopa/levodopa, unlike Comtan.
  • Tasmar (tolcapone) can cause dry mouth and changes in blood pressure. Changes in blood pressure can make you feel faint and more likely to fall.
  • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price
$1769.68
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Reviews
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Side effects
40possible side effects
  • Difficulty controlling movement
    42%
  • Nausea
    30%
  • Sleeping problems
    24%
  • Excessive dreaming
    21%
  • Muscle cramps
    19%
  • Loss of appetite
    19%
  • Sleepiness
    18%
  • Uncontrolled muscle spasms
    17%
  • Lightheadedness from standing
    17%
  • Diarrhea
    16%
  • Dizziness
    13%
  • Confusion
    11%
  • Headache
    10%
  • Hallucinations
    8%
  • Vomiting
    8%
  • Fatigue
    7%
  • Constipation
    6%
  • Common cold
    5%
  • Urinary tract infection
    5%
  • Dry mouth
    5%
  • Abdominal pain
    5%
  • Falls
    4%
  • Increased sweating
    4%
  • Fainting
    4%
  • Indigestion
    4%
  • Flu
    3%
  • Shortness of breath
    3%
  • Loss of balance
    3%
  • Increased abnormal movements
    3%
  • Chest pain
    3%
  • Tingling/prickling sensation
    3%
  • Urine discoloration
    2%
  • Gas
    2%
  • Low blood pressure
    2%
  • Stiffness
    2%
  • Joint pain
    2%
  • Problems with urination
    2%
  • Neck pain or stiffness
    2%
  • Burning sensation
    2%
  • Nasal congestion
    2%
See more detailed side effects
The Lodosyn (carbidopa) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Liver damage
    • Liver damage
  • Falling asleep during the day
    • Taking other medicines for Parkinson's disease
  • Diarrhea
  • Abnormal thinking and mood changes
    • Taking antipsychotic medicines
  • Difficulty controlling movements
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
See more detailed risks and warnings