Compare tolcapone vs. carbidopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

tolcapone

carbidopa

Treats Parkinson's disease. Taking Tasmar (tolcapone) is the next step to control Parkinson's disease when carbidopa/levodopa don't work as well, however you might be more likely to have liver damage.Treats Parkinson's disease when given with levodopa. Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.
Reviews & ratings
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Have you used Tasmar (tolcapone)?
Worth itNot sureNot worth it

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Have you used Lodosyn (carbidopa)?
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Side effects
tolcaponecarbidopa
  • Urine discoloration 1%
  • Low blood pressure 1%
  • Stiffness 1%
  • Joint pain 1%
  • Problems with urination 1%
  • Neck pain or stiffness 1%
  • Burning sensation 2%
  • Nasal congestion 2%
  • Flu 1%
More tolcapone side effects »

We haven’t found good data for carbidopa side effects.

FDA side effect reports for carbidopa »
How it works
tolcaponecarbidopa
Tasmar (tolcapone) is an enzyme inhibitor that stops levodopa from being broken down. It causes higher levodopa in the brain, which relieves the symptoms of Parkinson's disease.Lodosyn (carbidopa) is a decarboxylase inhibitor that allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
tolcaponecarbidopa
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
tolcaponecarbidopa
  • Pill
  • Pill
Used for
tolcaponecarbidopa
Risk factors for serious side effects
tolcaponecarbidopa
  • Liver damage
  • Taking other medicines for Parkinson's disease
  • Taking antipsychotic medicines
Detailed Tasmar (tolcapone) risks & warnings »
    Detailed Lodosyn (carbidopa) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    tolcaponecarbidopa
    • Tasmar (tolcapone) can be taken with or without food.
    No food related info.
    Upsides and benefits
    tolcaponecarbidopa
    • Tasmar (tolcapone) is part of the medicines used as the most common next step to control Parkinson's disease when carbidopa/levodopa doesn't work as well.
    • Tasmar (tolcapone) is available as a generic.
    • Tasmar (tolcapone) can be taken with or without food.
    • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
    • It is available in a combination pill with levodopa once you find the right dose that works for you.
    Downsides and risks
    tolcaponecarbidopa
    • When you first start taking Tasmar (tolcapone), your doctor might have to change the dose a lot because of all the side effects.
    • Tasmar (tolcapone) will only slow the disease down; it is not a cure for Parkinson's disease.
    • Unlike Comtan, Tasmar (tolcapone) is more likely to damage your liver, so you might need regular blood tests for the first few months.
    • Tasmar (tolcapone) is not available as a combination pill with carbidopa/levodopa, unlike Comtan.
    • Tasmar (tolcapone) can cause dry mouth and changes in blood pressure. Changes in blood pressure can make you feel faint and more likely to fall.
    • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
    Tips from our pharmacists for people taking the medication
    tolcaponecarbidopa
    • Tasmar (tolcapone) can make you dizzy if you've been sitting or lying down for a while. Be very careful when getting up.
    • Don't drive or do anything requiring concentration until you know how Tasmar (tolcapone) affects you.
    • Your urine might be colored dark orange or brown while taking Tasmar (tolcapone). This is normal.
    • You have to keep taking carbidopa/levodopa with Tasmar (tolcapone). Tasmar (tolcapone) won't work by itself to control your Parkinson's disease.
    • Talk to your doctor if you want to stop taking Tasmar (tolcapone). Stopping it suddenly can be very dangerous.
    • Lodosyn (carbidopa) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • Your saliva, sweat and urine may have dark color and stain your clothing while taking Lodosyn (carbidopa).
    • Take Lodosyn (carbidopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
    • Lodosyn (carbidopa) doesn't work when taken by itself. Don't stop taking your other medicines for Parkinson's disease.
    • Lodosyn (carbidopa) may cause unusual cravings in some people.
    Learn more
    More about tolcaponeSide effectsAlternativesFDA package insert
    Have you used Tasmar (tolcapone)?
    Worth itNot sureNot worth it
    More about carbidopaSide effectsAlternativesFDA package insert
    Have you used Lodosyn (carbidopa)?
    Worth itNot sureNot worth it