Compare tolcapone vs. carbidopa/levodopa/entacapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Tasmar
(tolcapone)

Stalevo
(carbidopa / levodopa / entacapone)

Treats Parkinson's disease. Taking Tasmar (tolcapone) is the next step to control Parkinson's disease when carbidopa/levodopa don't work as well, however you might be more likely to have liver damage.Treats Parkinson's disease. Stalevo (carbidopa / levodopa / entacapone) is a good choice for Parkinson's disease, especially when carbidopa/levodopa starts losing its effect.
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Reviews & ratings
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Have you used Tasmar (tolcapone)?
Worth itNot sureNot worth it

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Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it
Side effects
tolcaponecarbidopa/levodopa/entacapone
  • Difficulty controlling movement 22%
  • Nausea 12%
  • Sleeping problems 6%
  • Excessive dreaming 4%
  • Muscle cramps 2%
  • Loss of appetite 6%
  • Sleepiness 5%
  • Lightheadedness from standing 3%
  • Diarrhea 8%
More tolcapone side effects »
  • Difficulty controlling movements 10%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Discolored urine 10%
  • Muscle rigidity 1%
  • Abdominal pain 4%
  • Dizziness 2%
  • Fatigue 2%
  • Constipation 2%
More carbidopa/levodopa/entacapone side effects »
How it works
tolcaponecarbidopa/levodopa/entacapone
Tasmar (tolcapone) is an enzyme inhibitor that stops levodopa from being broken down. It causes higher levodopa in the brain, which relieves the symptoms of Parkinson's disease.Stalevo (carbidopa / levodopa / entacapone) is a combination of carbidopa, levodopa, and entacapone. Entacopone and carbidopa prevent breakdown of levodopa in the body so that levodopa can then enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
tolcaponecarbidopa/levodopa/entacapone
Prescription only
Prescription only
Available as
tolcaponecarbidopa/levodopa/entacapone
  • Pill
  • Pill
Used for
tolcaponecarbidopa/levodopa/entacapone
Risk factors for serious side effects
tolcaponecarbidopa/levodopa/entacapone
  • Liver damage
  • Taking other medicines for Parkinson's disease
    • Taking antipsychotic medicines
      • Taking other medicines for Parkinson's disease
      Detailed Tasmar (tolcapone) risks & warnings »
              • History of stomach ulcers
              Detailed Stalevo (carbidopa / levodopa / entacapone) risks & warnings »
              Pregnancy

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Food
              tolcaponecarbidopa/levodopa/entacapone
              • Tasmar (tolcapone) can be taken with or without food.
              No food related info.
              Upsides and benefits
              tolcaponecarbidopa/levodopa/entacapone
              • Tasmar (tolcapone) is part of the medicines used as the most common next step to control Parkinson's disease when carbidopa/levodopa doesn't work as well.
              • Tasmar (tolcapone) is available as a generic.
              • Tasmar (tolcapone) can be taken with or without food.
              • It combines three medicines into one pill so you don't have to take so many pills daily.
              • Stalevo (carbidopa / levodopa / entacapone) is available as a generic.
              Downsides and risks
              tolcaponecarbidopa/levodopa/entacapone
              • When you first start taking Tasmar (tolcapone), your doctor might have to change the dose a lot because of all the side effects.
              • Tasmar (tolcapone) will only slow the disease down; it is not a cure for Parkinson's disease.
              • Unlike Comtan, Tasmar (tolcapone) is more likely to damage your liver, so you might need regular blood tests for the first few months.
              • Tasmar (tolcapone) is not available as a combination pill with carbidopa/levodopa, unlike Comtan.
              • Tasmar (tolcapone) can cause dry mouth and changes in blood pressure. Changes in blood pressure can make you feel faint and more likely to fall.
              • You would first start by taking Stalevo (carbidopa / levodopa / entacapone) as two different pills, carbidopa/levodopa and entacapone, before you get switched over to Stalevo (carbidopa / levodopa / entacapone).
              • It's less customizable since there are only a few fixed combinations available.
              Tips from our pharmacists for people taking the medication
              tolcaponecarbidopa/levodopa/entacapone
              • Tasmar (tolcapone) can make you dizzy if you've been sitting or lying down for a while. Be very careful when getting up.
              • Don't drive or do anything requiring concentration until you know how Tasmar (tolcapone) affects you.
              • Your urine might be colored dark orange or brown while taking Tasmar (tolcapone). This is normal.
              • You have to keep taking carbidopa/levodopa with Tasmar (tolcapone). Tasmar (tolcapone) won't work by itself to control your Parkinson's disease.
              • Talk to your doctor if you want to stop taking Tasmar (tolcapone). Stopping it suddenly can be very dangerous.
              • Stalevo (carbidopa / levodopa / entacapone) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
              • Your saliva, sweat and urine may have dark color and stain your clothing while taking Stalevo (carbidopa / levodopa / entacapone).
              • Take Stalevo (carbidopa / levodopa / entacapone) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
              • Stalevo (carbidopa / levodopa / entacapone) may cause unusual cravings in some people.
              Learn more
              More about tolcaponeSide effectsAlternativesFDA package insert
              Have you used Tasmar (tolcapone)?
              Worth itNot sureNot worth it
              More about carbidopa/levodopa/entacaponeSide effectsAlternativesFDA package insert
              Have you used Stalevo (carbidopa / levodopa / entacapone)?
              Worth itNot sureNot worth it