Compare Topamax vs. Dantrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Topamax (topiramate)

Prescription only

Dantrium (dantrolene)

Prescription only
Prevents seizures and migraine headaches.

Topamax (topiramate) is very effective at preventing many types of seizures and migraines, but it can cause several severe side effects that can lead to stopping the medication.

3.3/ 5 average rating with 56 reviewsforTopamax
Relaxes your muscles.

Dantrium (dantrolene) effectively treats malignant hyperthermia (increased temperature and muscle contractions when receiving anesthesia) and is the only medicine used to treat the condition. Dantrium (dantrolene) is not a first-choice treatment for general muscle spasms because it can damage your liver.

Upsides
  • Can lower your number of seizures and also prevent migraine headaches. This medicine can be used on its own or with other antiepileptic medicines to lower the frequency of seizures.
  • Doesn't need routine blood tests like similar medications.
  • Available in short-acting and long-acting forms.
  • Comes as a generic, so it's relatively cheap.
  • Dantrium (dantrolene) effectively treats malignant hyperthermia.
  • Can be used for muscle spasticity if other medications haven't worked.
  • Available as generic.
Downsides
  • Can cause many severe side effects. People starting Topamax (topiramate) need to be monitored for these effects as soon as they start treatment.
  • This medicine can take 4 to 6 weeks for the full effects of this medication to kick in, especially for people taking it for migraines.
  • Children taking Topamax (topiramate) for long periods of time need to have their dose adjusted by their pediatrician as they grow.
  • At higher doses (ie. 400 mg/day), children may experience difficulty with concentration/attention, fever, flushing, and confusion.
  • Not a first-choice treatment for muscle spasms because it can cause liver damage.
  • Can cause dizziness, sleepiness, and sometimes severe diarrhea.
  • Needs routine blood tests since it can injure your liver.
  • Dose needs to be increased slowly to minimize side effects.
Used for
  • Malignant hyperthermia
  • Chronic spasticity
Dosage forms
  • Pill
  • Extended release capsule
  • Pill
  • Injection
Price
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Reviews
56 reviews so far
52%
saidit'sworth it
50%
saiditworked well
36%
saidit'sa big hassle

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Side effects
39possible side effects
  • Sleepiness
    26%
  • Loss of appetite
    24%
  • Fatigue
    16%
  • Injury
    14%
  • Nervousness
    14%
  • Personality disorder (behavior problems)
    11%
  • Difficulty with concentration/attention
    10%
  • Weight loss
    9%
  • Aggressive reaction
    9%
  • Abnormal gait
    8%
  • Purpura
    8%
  • Difficulty sleeping
    8%
  • Viral infection
    7%
  • Impaired coordination
    6%
  • Nausea
    6%
  • Increased saliva
    6%
  • Muscle spasm
    5%
  • Constipation
    5%
  • Difficulty with memory
    5%
  • Pneumonia
    5%
  • Dizziness
    4%
  • Speech disorders/ related speech problems
    4%
  • Nose bleed
    4%
  • Confusion
    4%
  • Urinary incontinence
    4%
  • Stomach flu
    3%
  • Psychomotor slowing
    3%
  • Skin disorder
    3%
  • Allergic reaction
    2%
  • Abnormal reflexes
    2%
  • Thirst
    2%
  • Pussing
    2%
  • Hair loss
    2%
  • Dermatitis
    2%
  • Increased hair growth
    2%
  • Red skin rash
    2%
  • Eye abnormality
    2%
  • Abnormal vision
    2%
  • Leukopenia
    2%
See more detailed side effects
The Dantrium (dantrolene) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Suicidal thoughts or behavior
    • History of depression
  • Fever and inability to sweat
    • Children
  • Mental and cognitive changes
    • History of metabolic disorders
    • People also taking Depakote
  • Kidney stones
    • Low-carb diet
    • Dehydration
    • Drug interactions
  • Vision problems
  • Withdrawal seizures
    • Stopping Topamax (topiramate) suddenly
See more detailed risks and warnings
  • Liver injury
    • Taking 800 mg or more Dantrium (dantrolene) per day
    • Women
    • Over 35 years old
    • Elderly
    • History of liver disease or dysfunction
  • Drowsiness and dizziness
    • Alcohol or recreational drug use
  • Sun sensitivity
  • Lung disease
    • COPD
    • Heart failure
See more detailed risks and warnings