Compare Topamax vs. Dantrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Qudexy Xr
(topiramate)

Dantrium
(dantrolene)

Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Relaxes your muscles. Dantrium (dantrolene) effectively treats malignant hyperthermia (increased temperature and muscle contractions when receiving anesthesia) and is the only medicine used to treat the condition. Dantrium (dantrolene) is not a first-choice treatment for general muscle spasms because it can damage your liver.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Topamax
Reviews for Topamax
52%
of people (All ages) say Topamax is worth it
50%
say it works well
36%
say it's a big hassle
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it

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Have you used Dantrium (dantrolene)?
Worth itNot sureNot worth it
Side effects
TopamaxDantrium
  • Ear, nose, or throat infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Inflammation inside the nose 5%
  • Tingling sensation 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »

The Dantrium FDA package insert doesn’t have numbers about how common side effects are.

More about Dantrium side effects »
How it works
TopamaxDantrium
Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Dantrium (dantrolene) stops spasms and relaxes muscle cells by interfering with the release of calcium inside muscle cells.
Type of medication
TopamaxDantrium
Prescription onlyPrescription only
Available as
TopamaxDantrium
  • Pill
  • Extended release capsule
  • Pill
  • Injection
Used for
TopamaxDantrium
  • Malignant Hyperthermia
Risk factors for serious side effects
TopamaxDantrium
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
  • Taking 800 mg or more Dantrium (dantrolene) per day
  • Women
  • Over 35 years old
  • Elderly
  • History of liver disease or dysfunction
Detailed Dantrium (dantrolene) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
TopamaxDantrium
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • A few people will get kidney stones.
No kidneys and liver related info.
Sleep
TopamaxDantrium
No sleep related info.
  • Taking Dantrium (dantrolene) may make you feel dizzy or sleepy for the first few days, especially if you drink alcohol or take recreational drugs. Avoid driving or other activities requiring concentration until you know how your body responds to the medication. Your body should adjust to the medicine. Talk to your doctor or pharmacist if these symptoms bother you.
  • Dantrium (dantrolene) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
Weight
TopamaxDantrium
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
No weight related info.
Upsides and benefits
TopamaxDantrium
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • Dantrium (dantrolene) effectively treats malignant hyperthermia.
  • Can be used for muscle spasticity if other medications haven't worked.
  • Available as generic.
Downsides and risks
TopamaxDantrium
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
  • Not a first-choice treatment for muscle spasms because it can cause liver damage.
  • Can cause dizziness, sleepiness, and sometimes severe diarrhea.
  • Needs routine blood tests since it can injure your liver.
  • Dose needs to be increased slowly to minimize side effects.
Tips from our pharmacists for people taking the medication
TopamaxDantrium
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • Dantrium (dantrolene) can worsen liver function.You may need to have your blood checked regularly before starting Dantrium (dantrolene) and while you're on it.
  • Dantrium (dantrolene) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Dantrium (dantrolene) can cause diarrhea, but it usually goes away within the first few weeks. If it doesn't, talk to your doctor.
  • May make your skin sensitive to the sun. Wear sunblock and avoid prolonged exposure to sunlight while on Dantrium (dantrolene).
Learn more
More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
More about DantriumSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dantrium (dantrolene)?
Worth itNot sureNot worth it