Compare Topamax vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Qudexy Xr (Topiramate)

Prescription only
Prevents seizures and migraine headaches.

Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.

4.4/ 7 average rating with 56 reviewsforTopamax
Prevents seizures and stabilizes mood.

Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.

4.4/ 7 average rating with 97 reviewsforDepakote
Upsides
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
Downsides
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Used for
Dosage forms
  • Pill
  • Extended release capsule
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Price
Lowest price near you
$10.2
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Lowest price near you
$293.48
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Reviews
56 
52%
think this treatment is worth it
50%
think this treatment works well
36%
think this treatment is a hassle

Have you used Qudexy Xr (Topiramate)?

Leave a review
97 
46%
think this treatment is worth it
40%
think this treatment works well
27%
think this treatment is a hassle

Have you used Depacon (Valproate, Valproic Acid, Or Divalproex)?

Leave a review
Side effects
10possible side effects
  • Somnolence
    28%
  • Dizziness
    25%
  • Ataxia
    16%
  • Nervousness
    16%
  • Fatigue
    15%
  • Speech disorders/Related speech problems
    13%
  • Psychomotor slowing
    13%
  • Vision abnormal
    13%
  • Difficulty with memory
    12%
  • Paresthesia
    11%
See more detailed side effects
10possible side effects
  • Nausea
    48%
  • Headache
    31%
  • Asthenia
    27%
  • Vomiting
    27%
  • Somnolence
    27%
  • Tremor
    25%
  • Dizziness
    25%
  • Abdominal Pain
    23%
  • Diplopia
    16%
  • Diarrhea
    13%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    History of depression

  • Uncontrolled body temperature

    Children

  • Mental changes due to high ammonia

    History of metabolic disorders

    ...and 1 more risk factors

  • Kidney stones

    Low-carb diet

    ...and 2 more risk factors

  • Withdrawal seizures

    Stopping Qudexy Xr (Topiramate) suddenly

See more detailed risks and warnings
  • Liver damage

    Children under age 2

    ...and 1 more risk factors

  • Suicidal thoughts or behavior

    History of depression

  • Mental changes due to high ammonia

    History of metabolic disorders

    ...and 1 more risk factors

  • Low body temperature

    People also taking Topamax

  • Withdrawal seizures

    Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly

See more detailed risks and warnings