Compare Topamax vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Qudexy Xr
(topiramate)

Depacon
(valproate, valproic acid, or divalproex)

Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Topamax
Reviews for Qudexy Xr (topiramate)
52%
of people (All ages) say Qudexy Xr (topiramate) is worth it
50%
say it works well
36%
say it's a big hassle
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
Reviews for Depacon (valproate, valproic acid, or divalproex)
46%
-6% worse vs. Qudexy Xr (topiramate)
40%
-10% worse vs. Qudexy Xr (topiramate)
27%
+9% better vs. Qudexy Xr (topiramate)
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
Side effects
TopamaxDepakote
  • Ear, nose, or throat infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Inflammation inside the nose 5%
  • Tingling sensation 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
  • Nausea 7%
  • Drowsiness 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Muscle weakness 3%
  • Abdominal pain 1%
  • Indigestion 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
How it works
TopamaxDepakote
Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
TopamaxDepakote
Prescription only
Prescription only
Available as
TopamaxDepakote
  • Pill
  • Extended release capsule
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for
TopamaxDepakote
Risk factors for serious side effects
TopamaxDepakote
  • History of depression
    • Children
    • History of metabolic disorders
    • People also taking Depakote
    • Low-carb diet
    • Dehydration
    • Drug interactions
      • Stopping Qudexy Xr (Topiramate) suddenly
      Detailed Qudexy Xr (topiramate) risks & warnings »
        • Children under age 2
        • History of metabolic disorders
          • History of depression
            • History of metabolic disorders
            • People also taking Topamax
            • People also taking Topamax
              • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
              Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
              Pregnancy

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Food
              TopamaxDepakote
              No food related info.
              • Take with food to avoid upset stomach.
              Kidneys and liver
              TopamaxDepakote
              • A few people will get kidney stones.
              • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
              • Can cause liver damage, so it's probably not safe if you already have liver problems.
              Weight
              TopamaxDepakote
              • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • May cause hair loss and weight gain.
              Upsides and benefits
              TopamaxDepakote
              • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
              • Helpful in preventing frequent migraine headaches.
              • Doesn't need routine blood tests.
              • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
              • One of the first-line options to stabilize mood for people with bipolar disorder.
              • Helpful in preventing frequent migraine headaches.
              Downsides and risks
              TopamaxDepakote
              • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
              • A few people will get kidney stones.
              • Not safe to use if you're pregnant.
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • Can cause liver damage, so it's probably not safe if you already have liver problems.
              • Not safe to use if you're pregnant.
              • Requires routine blood tests to see how the medicine is affecting your body.
              Tips from our pharmacists for people taking the medication
              TopamaxDepakote
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Can cause tingling skin sensations and reduced appetite.
              • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
              • Takes 3 to 4 weeks to feel full effects on mood.
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Requires routine blood tests.
              • Take with food to avoid upset stomach.
              • May cause hair loss and weight gain.
              • Different versions of Depakote have different dosing. Be careful.
              • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
              • Takes 3 to 4 weeks to feel full effects on mood.
              Learn more
              More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Qudexy Xr (topiramate)?
              Worth itNot sureNot worth it
              More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Depacon (valproate, valproic acid, or divalproex)?
              Worth itNot sureNot worth it