Compare Topamax vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Qudexy Xr
(Topiramate)

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.604166666666667Topamax
Reviews for Qudexy Xr (Topiramate)
54%
of people say Qudexy Xr (Topiramate) is worth it
52%
say it works well
33%
say it's a big hassle
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
8% vs. Qudexy Xr (Topiramate)
39%
13% vs. Qudexy Xr (Topiramate)
27%
+6% vs. Qudexy Xr (Topiramate)
Side effects
TopamaxDepakote
  • Tingling sensation 45%
  • Slowed-down thinking and movements 19%
  • Dizziness 17%
  • Drowsiness 17%
  • Fatigue 17%
  • Change in taste 14%
  • Difficulty with concentration/attention 13%
  • Nervousness 12%
  • Difficulty with memory 11%
  • Vision abnormal 11%
More Topamax side effects »
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »
How it works
TopamaxDepakote
Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
TopamaxDepakote
AnticonvulsantPrescription only
AnticonvulsantPrescription only
Available as
TopamaxDepakote
  • Pill
  • Extended release capsule
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for (click to learn more)
TopamaxDepakote
Risk factors for serious side effects
TopamaxDepakote
  • History of depression
    • Children
    • History of metabolic disorders
    • People also taking Depakote
    • Low-carb diet
    • Dehydration
    • Drug interactions
      • Stopping Qudexy Xr (Topiramate) suddenly
      Detailed Qudexy Xr (Topiramate) risks & warnings »
        • Children under age 2
        • History of metabolic disorders
          • History of depression
            • History of metabolic disorders
            • People also taking Topamax
            • People also taking Topamax
              • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
              Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
              Pregnancy category
              TopamaxDepakote
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              No specific food-related info.
              • Take with food to avoid upset stomach.
              Kidneys and liver
              • A few people will get kidney stones.
              • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
              No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • May cause hair loss and weight gain.
              Upsides and benefits
              TopamaxDepakote
              • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
              • Doesn't need routine blood tests.
              • Helpful in preventing frequent migraine headaches.
              • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
              • One of the first-line options to stabilize mood for people with bipolar disorder.
              • Helpful in preventing frequent migraine headaches.
              Downsides and risks
              TopamaxDepakote
              • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
              • A few people will get kidney stones.
              • Not safe to use if you're pregnant.
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • Can cause liver damage, so it's probably not safe if you already have liver problems.
              • Requires routine blood tests to see how the medicine is affecting your body.
              • Not safe to use if you're pregnant.
              Tips from our pharmacists for people taking the medication
              TopamaxDepakote
              • Can cause tingling skin sensations and reduced appetite.
              • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Takes 3 to 4 weeks to feel full effects on mood.
              • Requires routine blood tests.
              • Take with food to avoid upset stomach.
              • May cause hair loss and weight gain.
              • Different versions of Depakote have different dosing. Be careful.
              • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Takes 3 to 4 weeks to feel full effects on mood.
              Learn more
              More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
              More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert