Compare Topamax vs. Detrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Qudexy Xr
(topiramate)

Detrol
(tolterodine)

Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Treats overactive bladder. Detrol (tolterodine) is a good treatment for overactive bladder after exercises and other methods to control it haven't worked.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Topamax
Reviews for Topamax
52%
of people (All ages) say Topamax is worth it
50%
say it works well
36%
say it's a big hassle
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it

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Have you used Detrol (tolterodine)?
Worth itNot sureNot worth it
Side effects
TopamaxDetrol
  • Ear, nose, or throat infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Inflammation inside the nose 5%
  • Tingling sensation 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
  • Dry mouth 25%
  • Headache 2%
  • Constipation 3%
  • Dizziness 2%
  • Stomach pain 2%
  • Tiredness 1%
  • Diarrhea 1%
  • Indigestion 3%
  • Drowsiness 1%
  • Dry eyes 1%
More Detrol side effects »
How it works
TopamaxDetrol
Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Detrol (tolterodine) is an antimuscarinic. It helps people control the urge to urinate by relaxing the bladder muscles and stopping them from spasming.
Type of medication
TopamaxDetrol
Prescription onlyPrescription only
Available as
TopamaxDetrol
  • Pill
  • Extended release capsule
  • Pill
  • Extended release
Used for
TopamaxDetrol
Risk factors for serious side effects
TopamaxDetrol
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • People age 65 or older
  • Glaucoma
  • History of bladder problems
Detailed Detrol (tolterodine) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
TopamaxDetrol
No alcohol related info.
  • Drinks with caffeine, alcohol or carbonation can make your symptoms worse.
Food
TopamaxDetrol
No food related info.
  • You can take Detrol (tolterodine) with or without food.
Kidneys and liver
TopamaxDetrol
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • A few people will get kidney stones.
  • If you have liver or kidney problems, talk to your doctor before starting Detrol (tolterodine). You might have to use a lower dose, or you might not be able to take Detrol (tolterodine) at all.
Sleep
TopamaxDetrol
No sleep related info.
  • You can get drowsy or dizzy on Detrol (tolterodine). Do not stand or sit up too quickly if you've been sitting or lying down for a while.
  • Detrol (tolterodine) can cause drowsiness, dizziness and can increase your risk for falls.
Weight
TopamaxDetrol
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
No weight related info.
Upsides and benefits
TopamaxDetrol
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • Detrol (tolterodine) is effective at treating overactive bladder by lowering the urge to urinate, and controlling urination.
  • The tablet is available as a generic in both extended and immediate release, so you can take it once or twice a day.
Downsides and risks
TopamaxDetrol
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
  • Detrol (tolterodine) can cause drowsiness, dizziness and can increase your risk for falls.
  • Detrol (tolterodine) can cause severe dry mouth and eyes and constipation.
  • Generally not recommended if you are 65 or older.
  • Do not use if you have uncontrolled narrow-angle glaucoma.
Tips from our pharmacists for people taking the medication
TopamaxDetrol
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • Detrol (tolterodine) can take up to 4 weeks before you notice any changes.
  • Drinks with caffeine, alcohol or carbonation can make your symptoms worse.
  • You can get drowsy or dizzy on Detrol (tolterodine). Do not stand or sit up too quickly if you've been sitting or lying down for a while.
  • You can take Detrol (tolterodine) with or without food.
  • Do not break, crush or chew extended-release capsules.
Learn more
More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
More about DetrolSide effectsAlternativesFDA package insert
Have you used Detrol (tolterodine)?
Worth itNot sureNot worth it