Compare Topamax vs. Keppra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Qudexy Xr
(topiramate)

Keppra
(levetiracetam)

Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Prevents seizures. Keppra (Levetiracetam) is effective for preventing seizures in people with epilepsy. Compared to other anti-seizure medications, it has few drug interactions and you don’t need to get your levels checked.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Topamax
Reviews for Topamax
52%
of people (All ages) say Topamax is worth it
50%
say it works well
36%
say it's a big hassle
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
Reviews for Keppra
33%
+19% better vs. Topamax
81%
-31% worse vs. Topamax
33%
-3% worse vs. Topamax
Have you used Keppra (levetiracetam)?
Worth itNot sureNot worth it
Side effects
TopamaxKeppra
  • Ear, nose, or throat infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Inflammation inside the nose 5%
  • Tingling sensation 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
  • Headache 4%
  • Muscle weakness 6%
  • Vomiting 3%
  • Any side effect 3%
  • Common cold 3%
  • Drowsiness 7%
  • Infection 5%
  • Irritability 12%
  • Neck pain 6%
  • Sore throat 7%
More Keppra side effects »
How it works
TopamaxKeppra
Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Keppra (Levetiracetam) is an antiepileptic medication. It prevents seizures by helping regulate neurotransmitters in the brain.
Type of medication
TopamaxKeppra
Prescription onlyPrescription only
Available as
TopamaxKeppra
  • Pill
  • Extended release capsule
  • Pill
  • Extended release
  • Liquid
Used for
TopamaxKeppra
Risk factors for serious side effects
TopamaxKeppra
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
  • History of depression
  • Starting the first month of therapy
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Stopping Keppra (Levetiracetam) suddenly
Detailed Keppra (levetiracetam) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
TopamaxKeppra
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • A few people will get kidney stones.
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
Sleep
TopamaxKeppra
No sleep related info.
  • Taking Keppra (Levetiracetam) can make you feel sleepy, dizzy, and affect your coordination. Avoid activities that require you to be alert, such as driving a car or operating machinery, until you know how Keppra (Levetiracetam) affects you.
  • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
Weight
TopamaxKeppra
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
No weight related info.
Upsides and benefits
TopamaxKeppra
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • Lowers the frequency of seizures, including partial-onset, generalized tonic-clonic, and myoclonic seizures.
  • Unlike many other medications for epilepsy, this has very few drug interactions, so your other medicines shouldn't be affected.
  • If you have trouble swallowing tablets, Keppra (Levetiracetam) is also available as an oral solution.
  • You won’t need to get regular blood tests to check the drug levels in your body.
Downsides and risks
TopamaxKeppra
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
  • It’s important to take your dose on time so that Keppra (Levetiracetam) has consistent levels in your body.
  • May not be the best drug to take if you have a history of psychiatric issues, such as depression or bipolar disorder.
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
  • Keppra (Levetiracetam) is only FDA-approved to be taken with other medicines to treat epilepsy.
Tips from our pharmacists for people taking the medication
TopamaxKeppra
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
  • If you start having skin rashes or changes in your mood, tell your doctor immediately.
  • If you need to stop taking Keppra (Levetiracetam), do so over at least one week to prevent withdrawal seizures.
  • If you are taking the oral solution, use the measuring device given with the medicine. Don’t use your household tablespoons to measure.
  • Don’t crush or cut this medicine before taking it, or else you’ll have dangerously high levels of this drug in your body.
Learn more
More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
More about KeppraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Keppra (levetiracetam)?
Worth itNot sureNot worth it