Compare Topamax vs. Neurontin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Qudexy Xr
(Topiramate)

Neurontin
(Gabapentin)

Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.
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Reviews & ratings
Button Group. All currently active
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4.604166666666667Topamax
Reviews for Qudexy Xr (Topiramate)
54%
of people say Qudexy Xr (Topiramate) is worth it
52%
say it works well
33%
say it's a big hassle
Reviews for Neurontin (Gabapentin)
57%
+3% vs. Qudexy Xr (Topiramate)
39%
13% vs. Qudexy Xr (Topiramate)
19%
+14% vs. Qudexy Xr (Topiramate)
Side effects
TopamaxNeurontin
  • Tingling sensation 45%
  • Slowed-down thinking and movements 19%
  • Dizziness 17%
  • Drowsiness 17%
  • Fatigue 17%
  • Change in taste 14%
  • Difficulty with concentration/attention 13%
  • Nervousness 12%
  • Difficulty with memory 11%
  • Vision abnormal 11%
More Topamax side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Lack of muscle coordination 7%
  • Leg or ankle swelling 6%
  • Fatigue 6%
  • Hostility 5%
  • Involuntary eye movement 4%
  • Double vision 4%
  • Tremor 4%
  • Dry mouth 4%
More Neurontin side effects »
How it works
TopamaxNeurontin
Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
TopamaxNeurontin
AnticonvulsantPrescription only
Anticonvulsant
GABA analog
Prescription only
Available as
TopamaxNeurontin
  • Pill
  • Extended release capsule
  • Pill
  • Oral solution
Used for (click to learn more)
TopamaxNeurontin
Risk factors for serious side effects
TopamaxNeurontin
  • History of depression
    • Children
    • History of metabolic disorders
    • People also taking Depakote
    • Low-carb diet
    • Dehydration
    • Drug interactions
      • Stopping Qudexy Xr (Topiramate) suddenly
      Detailed Qudexy Xr (Topiramate) risks & warnings »
        • Children ages 3 to 12
          • Taking with alcohol or drugs
          • Stopping Neurontin (Gabapentin) suddenly
          Detailed Neurontin (Gabapentin) risks & warnings »
          Pregnancy category
          TopamaxNeurontin
          DFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.
          • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
          Food
          No specific food-related info.
          • Take the extended-release tablet with food.
          Kidneys and liver
          • A few people will get kidney stones.
          • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
          No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.
          • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
          Weight
          • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
          No specific weight-related info.
          Upsides and benefits
          TopamaxNeurontin
          • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
          • Helpful in preventing frequent migraine headaches.
          • Doesn't need routine blood tests.
          • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
          • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
          • It's available as a generic, so it's less expensive than similar medications.
          Downsides and risks
          TopamaxNeurontin
          • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
          • A few people will get kidney stones.
          • Not safe to use if you're pregnant.
          • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
          • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
          Tips from our pharmacists for people taking the medication
          TopamaxNeurontin
          • For the first week, avoid activities that require you to be alert.
          • Don't use if pregnant.
          • Can cause tingling skin sensations and reduced appetite.
          • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
          • Takes 3 to 4 weeks to feel full effects on mood.
          • Side effects are common, but usually manageable.
          • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
          • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
          • Take the extended-release tablet with food.
          • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
          Learn more
          More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
          More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert