Compare Topamax vs. Neurontin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Qudexy Xr
(topiramate)

Neurontin
(gabapentin)

Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Topamax
Reviews for Topamax
52%
of people (All ages) say Topamax is worth it
50%
say it works well
36%
say it's a big hassle
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
Reviews for Neurontin
57%
-5% worse vs. Topamax
40%
+10% better vs. Topamax
19%
-17% worse vs. Topamax
620 reviews
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
Side effects
TopamaxNeurontin
  • Ear, nose, or throat infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Inflammation inside the nose 5%
  • Tingling sensation 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
How it works
TopamaxNeurontin
Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
TopamaxNeurontin
Prescription onlyPrescription only
Available as
TopamaxNeurontin
  • Pill
  • Extended release capsule
  • Pill
  • Oral solution
Used for
TopamaxNeurontin
Risk factors for serious side effects
TopamaxNeurontin
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed Neurontin (gabapentin) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
TopamaxNeurontin
No food related info.
  • Take the extended-release tablet with food.
Kidneys and liver
TopamaxNeurontin
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • A few people will get kidney stones.
No kidneys and liver related info.
Pain
TopamaxNeurontin
No pain related info.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
Sleep
TopamaxNeurontin
No sleep related info.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
Weight
TopamaxNeurontin
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
No weight related info.
Upsides and benefits
TopamaxNeurontin
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
Downsides and risks
TopamaxNeurontin
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
Tips from our pharmacists for people taking the medication
TopamaxNeurontin
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
Learn more
More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it