Compare Topamax vs. Oxybutynin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Qudexy Xr (Topiramate)

Prescription only

Oxytrol (Oxybutynin)

Prescription only
Prevents seizures and migraine headaches.

Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.

4.4/ 7 average rating with 56 reviewsforTopamax
Treats an overactive bladder.

Oxytrol (Oxybutynin) is a good treatment for overactive bladder, but watch out for side effects such as dry mouth and constipation.

  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • Oxytrol (Oxybutynin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • Available in multiple forms: a patch, gel, extended-release tablet, and tablet.
  • The gel form of Oxytrol (Oxybutynin) is available over the counter without a prescription.
  • Oxytrol (Oxybutynin) patch and gel have fewer side effects than taking the tablet.
  • The tablet is available as a generic.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Can’t be used if you have uncontrolled narrow-angle glaucoma.
  • Not recommended if you have ulcerative colitis or certain other stomach problems since Oxytrol (Oxybutynin) can slow stomach emptying.
  • Not the best choice if you have GERD (acid reflux), since Oxytrol (Oxybutynin) can irritate your throat and make the acid reflux worse.
  • Has more side effects than newer medicines that treat overactive bladder.
Used for
Dosage forms
  • Pill
  • Extended release capsule
  • Pill
  • Extended release
  • Liquid
  • Cream, gel, or ointment
  • Patch
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Side effects
10possible side effects
  • Somnolence
  • Dizziness
  • Ataxia
  • Nervousness
  • Fatigue
  • Speech disorders/Related speech problems
  • Psychomotor slowing
  • Vision abnormal
  • Difficulty with memory
  • Paresthesia
See more detailed side effects
The Oxytrol (Oxybutynin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Suicidal thoughts or behavior

    History of depression

  • Uncontrolled body temperature


  • Mental changes due to high ammonia

    History of metabolic disorders

    ...and 1 more risk factors

  • Kidney stones

    Low-carb diet

    ...and 2 more risk factors

  • Withdrawal seizures

    Stopping Qudexy Xr (Topiramate) suddenly

See more detailed risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Heat exhaustion

    Outside in hot weather

    ...and 2 more risk factors

See more detailed risks and warnings