Compare Topamax vs. Propranolol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Qudexy Xr
(topiramate)

Inderal
(propranolol)

Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.
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Coupons for Topamax
Best available price for 60 (25mg) tablets of topamax
Coupons for Propranolol
Best available price for 60 (20mg) tablets of propranolol
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Topamax
Reviews for Topamax
52%
of people (All ages) say Topamax is worth it
50%
say it works well
36%
say it's a big hassle
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
Reviews for Propranolol
66%
-14% worse vs. Topamax
62%
-12% worse vs. Topamax
15%
-21% worse vs. Topamax
Have you used Inderal (propranolol)?
Worth itNot sureNot worth it
Side effects
TopamaxPropranolol
  • Ear, nose, or throat infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Inflammation inside the nose 5%
  • Tingling sensation 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
  • Dizziness 5%
  • Fatigue 2%
  • Constipation 3%
More Propranolol side effects »
How it works
TopamaxPropranolol
Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
TopamaxPropranolol
Prescription onlyPrescription only
Available as
TopamaxPropranolol
  • Pill
  • Extended release capsule
  • Pill
  • Extended release
  • Liquid
Used for
TopamaxPropranolol
Risk factors for serious side effects
TopamaxPropranolol
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
  • Suddenly stopping Inderal (Propranolol)
  • Major surgery requiring anesthesia
  • Diabetes
  • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
Detailed Inderal (propranolol) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
TopamaxPropranolol
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • A few people will get kidney stones.
No kidneys and liver related info.
Weight
TopamaxPropranolol
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
No weight related info.
Upsides and benefits
TopamaxPropranolol
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • A first-choice treatment to prevent chest pain (angina).
  • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
  • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
Downsides and risks
TopamaxPropranolol
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
Tips from our pharmacists for people taking the medication
TopamaxPropranolol
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause insomnia and fatigue.
  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
  • Don't stop taking this medicine suddenly.
Learn more
More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Inderal (propranolol)?
Worth itNot sureNot worth it