Compare Topamax vs. Vesicare

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Qudexy Xr
(topiramate)

Vesicare
(solifenacin)

Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Treats an overactive bladder. Vesicare (Solifenacin) is a good treatment for overactive bladder and doesn’t have as many side effects as similar medications.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.43Topamax
Reviews for Topamax
52%
of people (All ages) say Topamax is worth it
50%
say it works well
36%
say it's a big hassle
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it

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Have you used Vesicare (solifenacin)?
Worth itNot sureNot worth it
Side effects
TopamaxVesicare
  • Ear, nose, or throat infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Inflammation inside the nose 5%
  • Tingling sensation 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
  • Dry mouth 7%
  • Constipation 2%
  • Vision blurred 2%
  • Abdominal pain upper 1%
  • Flu 1%
  • Indigestion 3%
  • Dry eyes nos 1%
More Vesicare side effects »
How it works
TopamaxVesicare
Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Vesicare (Solifenacin) is an anticholinergic. It relaxes the bladder muscles by lowering muscle spasms. This helps people go to the bathroom less often and better control their urination.
Type of medication
TopamaxVesicare
Prescription onlyPrescription only
Available as
TopamaxVesicare
  • Pill
  • Extended release capsule
  • Pill
Used for
TopamaxVesicare
Risk factors for serious side effects
TopamaxVesicare
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Outside in hot weather
  • Dehydrated
  • Exercising
Detailed Vesicare (solifenacin) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
TopamaxVesicare
No interactions related info.
  • Has some drug interactions, so make sure your doctor has your complete list of medications.
Alcohol
TopamaxVesicare
No alcohol related info.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
Food
TopamaxVesicare
No food related info.
  • Can be taken with or without food.
  • Can be taken with or without food.
Kidneys and liver
TopamaxVesicare
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • A few people will get kidney stones.
No kidneys and liver related info.
Sleep
TopamaxVesicare
No sleep related info.
  • Vesicare (Solifenacin) can cause drowsiness, confusion, dizziness, hallucinations, or blurred vision. Avoid driving, operating machinery, or doing anything that requires you to be alert until you know how Vesicare (Solifenacin) affects you.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
Weight
TopamaxVesicare
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
No weight related info.
Upsides and benefits
TopamaxVesicare
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • Vesicare (Solifenacin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • Can be taken with or without food.
  • Causes fewer side effects than other medications in the same drug class.
  • Only needs to be taken once a day.
Downsides and risks
TopamaxVesicare
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Can’t be used if you have uncontrolled narrow-angle glaucoma.
  • Not recommended if you have ulcerative colitis or certain other gastrointestinal problems, since Vesicare (Solifenacin) can slow stomach emptying.
  • Has some drug interactions, so make sure your doctor has your complete list of medications.
  • Not available as a generic.
Tips from our pharmacists for people taking the medication
TopamaxVesicare
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
  • Can be taken with or without food.
  • Let your doctor know if your symptoms don’t get better in two weeks. There could be other causes of your bladder problems or you may need to try a different medicine.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
Learn more
More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
More about VesicareSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vesicare (solifenacin)?
Worth itNot sureNot worth it