Compare Toprol XL vs. Bisoprolol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Toprol Xl
(Metoprolol Succinate)

Zebeta
(Bisoprolol)

Lowers blood pressure and controls heart rate. Toprol Xl (Metoprolol Succinate) is good for controlling chest pain and treating heart failure and heart attack. You can't miss doses.Lowers blood pressure. Zebeta (Bisoprolol) is usually given to people who have taken other blood pressure meds unsuccessfully or have recently had significant heart problems.
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Reviews & ratings
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5.220858895705521Toprol XL
Reviews for Toprol Xl (Metoprolol Succinate)
60%
of people say Toprol Xl (Metoprolol Succinate) is worth it
55%
say it works well
13%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
Toprol XLBisoprolol
  • Abnormally slow heartbeat 9%
  • Low blood pressure 4%
  • Heart block 3%
More Toprol XL side effects »

We haven’t found good data for Bisoprolol side effects.

FDA side effect reports for Bisoprolol »
How it works
Toprol XLBisoprolol
Toprol Xl (Metoprolol Succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Zebeta (Bisoprolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.
Type of medication
Toprol XLBisoprolol
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
Toprol XLBisoprolol
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
Toprol XLBisoprolol
Risk factors for serious side effects
Toprol XLBisoprolol
  • Diabetes
    • Coronary artery disease
    • Heart failure
    • Major surgery requiring anesthesia
    • History of asthma
    Detailed Toprol Xl (Metoprolol Succinate) risks & warnings »
    • Diabetes
      • Coronary artery disease
      • Heart failure
      • Major surgery requiring anesthesia
      Detailed Zebeta (Bisoprolol) risks & warnings »
      Pregnancy category
      Toprol XLBisoprolol
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      Toprol XLBisoprolol
      • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
      • A first-choice treatment for heart failure. May prevent long-term heart damage.
      • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
      • Toprol XL is the extended release version of Lopressor.
      • Good for protecting the heart and lowering blood pressure if you've had a heart attack.
      • Available in a generic version.
      • Also comes in combination with other medications to lower blood pressure.
      Downsides and risks
      Toprol XLBisoprolol
      • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
      • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
      • Can hide symptoms of low blood sugar if you're diabetic.
      • You can't miss doses. Stopping Toprol XL suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • This isn't a first choice medication to lower blood pressure.
      • You can't stop taking it suddenly, or else you're more likely to have a heart attack or other problems with your heart.
      Tips from our pharmacists for people taking the medication
      Toprol XLBisoprolol
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Can cause fatigue and headache.
      • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
      • Don't stop taking this medicine suddenly.
      • Extended release version. Also comes in immediate release called Lopressor (metoprolol tartrate).
      • Zebeta (Bisoprolol) can make you feel dizzy the first few days you take it, so be careful driving and quickly standing up until you know how your body reacts to it.
      • Don't stop taking it suddenly without talking to your doctor.
      • If you have diabetes, Zebeta (Bisoprolol) can make it difficult to tell if your blood sugar is low.
      • Can cause headache, fatigue, and make you more likely to get colds or the flu.
      Learn more
      More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
      More about BisoprololSide effectsReviews & ratingsAlternativesFDA package insert