Compare Toprol XL vs. Bisoprolol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Toprol XL
(metoprolol succinate)

Zebeta
(bisoprolol)

Lowers blood pressure and controls heart rate. Toprol XL (metoprolol succinate) is good for controlling chest pain, treating heart failure, and heart attack. It has the added benefit of being taken once a day.Lowers blood pressure. Zebeta (Bisoprolol) is usually given to people who have taken other blood pressure meds unsuccessfully or have recently had significant heart problems.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.2Toprol XL
Reviews for Toprol XL
60%
of people (All ages) say Toprol XL is worth it
54%
say it works well
13%
say it's a big hassle
164 reviews
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it
Reviews for Bisoprolol
67%
-7% worse vs. Toprol XL
61%
-7% worse vs. Toprol XL
28%
+15% better vs. Toprol XL
Have you used Zebeta (bisoprolol)?
Worth itNot sureNot worth it
Side effects
Toprol XLBisoprolol
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Skin rash and itching 5%
  • Diarrhea 5%
  • Shortness of breath 3%
  • Slower heartbeat 3%
  • Dizziness/balance problems 1%
More Toprol XL side effects »

We haven’t found good data for Bisoprolol side effects.

FDA side effect reports for Bisoprolol »
How it works
Toprol XLBisoprolol
Toprol XL (metoprolol succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Zebeta (Bisoprolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.
Type of medication
Toprol XLBisoprolol
Prescription onlyPrescription only
Available as
Toprol XLBisoprolol
  • Extended release
  • Pill
Used for
Toprol XLBisoprolol
Risk factors for serious side effects
Toprol XLBisoprolol
  • Sudden discontinuation of medicine
  • Coronary artery disease
  • Diabetes
  • Hyperthyroidsim
  • Heart failure
Detailed Toprol XL (metoprolol succinate) risks & warnings »
  • Diabetes
  • Coronary artery disease
  • Heart failure
  • Major surgery requiring anesthesia
Detailed Zebeta (bisoprolol) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
Toprol XLBisoprolol
  • A first-choice treatment to prevent chest pain (angina). It makes attacks less frequent and helps you be more active without having chest pain.
  • Toprol XL (metoprolol succinate) is a first-choice treatment for heart failure since it may prevent long-term heart damage.
  • It's also a first-choice for heart attack treatment since it lowers the risk of death during and after a heart attack.
  • Toprol XL (metoprolol succinate) is the extended release version of metoprolol tartrate and only needs to be taken once a day.
  • It's available as a generic and is relatively cheap.
  • Good for protecting the heart and lowering blood pressure if you've had a heart attack.
  • Available in a generic version.
  • Also comes in combination with other medications to lower blood pressure.
Downsides and risks
Toprol XLBisoprolol
  • Taking a beta blocker can make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some this may not go away.
  • It's not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
  • Toprol XL (metoprolol succinate) can hide symptoms of low blood sugar if you have diabetes.
  • You can't miss doses. Stopping Toprol XL (metoprolol succinate) suddenly can cause your blood pressure to go up quickly, which increases your risk of heart attack and stroke.
  • This isn't a first choice medication to lower blood pressure.
  • You can't stop taking it suddenly, or else you're more likely to have a heart attack or other problems with your heart.
Tips from our pharmacists for people taking the medication
Toprol XLBisoprolol
  • Toprol XL (metoprolol succinate) cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine and let your doctor know if it hasn't improved.
  • It can make you feel tired or give you headaches.
  • Can hide symptoms of low blood sugar, so be careful taking this if you have diabetes.
  • Don't stop taking this medicine suddenly.
  • This is the extended-release version, but it also comes in an immediate-release form, metoprolol tartrate.
  • Zebeta (Bisoprolol) can make you feel dizzy the first few days you take it, so be careful driving and quickly standing up until you know how your body reacts to it.
  • Don't stop taking it suddenly without talking to your doctor.
  • If you have diabetes, Zebeta (Bisoprolol) can make it difficult to tell if your blood sugar is low.
  • Can cause headache, fatigue, and make you more likely to get colds or the flu.
Learn more
More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it
More about BisoprololSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zebeta (bisoprolol)?
Worth itNot sureNot worth it