Compare Toprol XL vs. Bystolic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Toprol Xl
(Metoprolol Succinate)

Bystolic
(Nebivolol)

Lowers blood pressure and controls heart rate. Toprol Xl (Metoprolol Succinate) is good for controlling chest pain and treating heart failure and heart attack. You can't miss doses.Lowers blood pressure and controls heart rate. Bystolic (Nebivolol) is a good blood pressure-lowering medicine for people with heart conditions, and has fewer side effects than other beta blockers, but it's expensive. You can't miss doses.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.2Toprol XL
Reviews for Toprol Xl (Metoprolol Succinate)
60%
of people (All ages) say Toprol Xl (Metoprolol Succinate) is worth it
54%
say it works well
13%
say it's a big hassle
164 reviews
Have you used Toprol Xl (Metoprolol Succinate)?
Worth itNot sureNot worth it
Reviews for Bystolic (Nebivolol)
53%
7% vs. Toprol Xl (Metoprolol Succinate)
49%
5% vs. Toprol Xl (Metoprolol Succinate)
18%
5% vs. Toprol Xl (Metoprolol Succinate)
154 reviews
Have you used Bystolic (Nebivolol)?
Worth itNot sureNot worth it
Side effects
Toprol XLBystolic
  • Abnormally slow heartbeat 9%
  • Low blood pressure 4%
  • Heart block 3%
More Toprol XL side effects »
  • Fatigue 4%
  • Headache 3%
  • Dizziness 2%
  • Diarrhea 1%
More Bystolic side effects »
How it works
Toprol XLBystolic
Toprol Xl (Metoprolol Succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Bystolic (Nebivolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.
Type of medication
Toprol XLBystolic
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
Toprol XLBystolic
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
Toprol XLBystolic
Risk factors for serious side effects
Toprol XLBystolic
  • Diabetes
  • Coronary artery disease
  • Heart failure
  • Major surgery requiring anesthesia
  • History of asthma
Detailed risks & warnings »
  • Sudden discontinuation of medicine
  • History of asthma
  • History of diabetes
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
Toprol XLBystolic
  • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
  • A first-choice treatment for heart failure. May prevent long-term heart damage.
  • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
  • Toprol XL is the extended release version of Lopressor.
  • Controls your heart rate to reduce work for your heart.
  • A first-line treatment for heart failure and heart attack.
  • Helps to lower blood pressure if you can't use first-choice treatments or need additional blood pressure control.
  • Many beta blockers can worsen asthma or cause headaches, but Bystolic usually doesn't because it targets the heart more specifically and causes fewer side effects.
Downsides and risks
Toprol XLBystolic
  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
  • You can't miss doses. Stopping Toprol XL suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • Not available in less expensive generic form.
  • You can't miss doses. Stopping Bystolic suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Can hide symptoms of low blood sugar if you're diabetic.
Tips from our pharmacists for people taking the medication
Toprol XLBystolic
  • Can cause dizziness in the first few days.
  • Can cause fatigue and headache.
  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
  • Extended release version. Also comes in immediate release called Lopressor (metoprolol tartrate).
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Don't stop taking this medicine suddenly.
  • Can cause headache, dizziness, or feeling short of breath in the first few days.
  • If side effects don't go away, talk to your doctor about alternatives.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Don't stop taking this medicine suddenly.
Learn more
More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Toprol Xl (Metoprolol Succinate)?
Worth itNot sureNot worth it
More about BystolicSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Bystolic (Nebivolol)?
Worth itNot sureNot worth it