Compare Toprol XL vs. Bystolic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Toprol XL
(metoprolol succinate)

Bystolic
(nebivolol)

Lowers blood pressure and controls heart rate. Toprol XL (metoprolol succinate) is good for controlling chest pain, treating heart failure, and heart attack. It has the added benefit of being taken once a day.Lowers blood pressure and controls heart rate. Bystolic (Nebivolol) is a good blood pressure-lowering medicine for people with heart conditions, and has fewer side effects than other beta blockers, but it's expensive. You can't miss doses.
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Coupons for Toprol XL
Best available price for 30 (25mg) tablets of toprol-xl
Coupons for Bystolic
Best available price for 30 (10mg) tablets of bystolic
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.2Toprol XL
Reviews for Toprol XL
60%
of people (All ages) say Toprol XL is worth it
54%
say it works well
13%
say it's a big hassle
164 reviews
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it
Reviews for Bystolic
53%
+7% better vs. Toprol XL
49%
+5% better vs. Toprol XL
18%
+5% better vs. Toprol XL
154 reviews
Have you used Bystolic (nebivolol)?
Worth itNot sureNot worth it
Side effects
Toprol XLBystolic
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Skin rash and itching 5%
  • Diarrhea 5%
  • Shortness of breath 3%
  • Slower heartbeat 3%
  • Dizziness/balance problems 1%
More Toprol XL side effects »
  • Headache 3%
  • Fatigue 1%
  • Nausea 3%
More Bystolic side effects »
How it works
Toprol XLBystolic
Toprol XL (metoprolol succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Bystolic (Nebivolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.
Type of medication
Toprol XLBystolic
Prescription onlyPrescription only
Available as
Toprol XLBystolic
  • Extended release
  • Pill
Used for
Toprol XLBystolic
Risk factors for serious side effects
Toprol XLBystolic
  • Sudden discontinuation of medicine
  • Coronary artery disease
  • Diabetes
  • Hyperthyroidsim
  • Heart failure
Detailed Toprol XL (metoprolol succinate) risks & warnings »
  • Sudden discontinuation of medicine
  • History of asthma
  • History of diabetes
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
Detailed Bystolic (nebivolol) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
Toprol XLBystolic
  • A first-choice treatment to prevent chest pain (angina). It makes attacks less frequent and helps you be more active without having chest pain.
  • Toprol XL (metoprolol succinate) is a first-choice treatment for heart failure since it may prevent long-term heart damage.
  • It's also a first-choice for heart attack treatment since it lowers the risk of death during and after a heart attack.
  • Toprol XL (metoprolol succinate) is the extended release version of metoprolol tartrate and only needs to be taken once a day.
  • It's available as a generic and is relatively cheap.
  • Controls your heart rate to reduce work for your heart.
  • A first-line treatment for heart failure and heart attack.
  • Helps to lower blood pressure if you can't use first-choice treatments or need additional blood pressure control.
  • Many beta blockers can worsen asthma or cause headaches, but Bystolic usually doesn't because it targets the heart more specifically and causes fewer side effects.
Downsides and risks
Toprol XLBystolic
  • Taking a beta blocker can make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some this may not go away.
  • It's not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
  • Toprol XL (metoprolol succinate) can hide symptoms of low blood sugar if you have diabetes.
  • You can't miss doses. Stopping Toprol XL (metoprolol succinate) suddenly can cause your blood pressure to go up quickly, which increases your risk of heart attack and stroke.
  • Not available in less expensive generic form.
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • You can't miss doses. Stopping Bystolic suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
Tips from our pharmacists for people taking the medication
Toprol XLBystolic
  • Toprol XL (metoprolol succinate) cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine and let your doctor know if it hasn't improved.
  • It can make you feel tired or give you headaches.
  • Can hide symptoms of low blood sugar, so be careful taking this if you have diabetes.
  • Don't stop taking this medicine suddenly.
  • This is the extended-release version, but it also comes in an immediate-release form, metoprolol tartrate.
  • Can cause headache, dizziness, or feeling short of breath in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • If side effects don't go away, talk to your doctor about alternatives.
  • Don't stop taking this medicine suddenly.
Learn more
More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it
More about BystolicSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Bystolic (nebivolol)?
Worth itNot sureNot worth it