Toprol XL vs. Catapres

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Scroll horizontally → to see comparisons

Toprol Xl
(Metoprolol Succinate)


Lowers blood pressure and controls heart rate. Toprol Xl (Metoprolol Succinate) is good for controlling chest pain and treating heart failure and heart attack. You can't miss doses.Lowers blood pressure. Catapres (Clonidine) is a good addition if you need more than one medicine to control your blood pressure, but it has a lot of side effects. You can't miss doses.
How it works
Toprol Xl (Metoprolol Succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Catapres (Clonidine) is an alpha-2 agonist. It works in the brain to tell your blood vessels to relax, and it lowers the activity of certain stress hormones. This lowers blood pressure.
Type of medication
Beta blocker
Prescription only
Alpha agonist
Prescription only
Available as
  • Pill
  • Extended release
  • Pill
  • Extended release
  • Patch
Used for (click to learn more)
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.220858895705521Toprol XL
Reviews for Toprol Xl (Metoprolol Succinate)
of people say Toprol Xl (Metoprolol Succinate) is worth it
say it works well
say it's a big hassle
Reviews for Catapres (Clonidine)
-18% vs. Toprol Xl (Metoprolol Succinate)
-22% vs. Toprol Xl (Metoprolol Succinate)
-21% vs. Toprol Xl (Metoprolol Succinate)
Side effects
  • Abnormally slow heartbeat 9%
  • Low blood pressure 4%
  • Heart block 3%
More Toprol XL side effects »

The Catapres FDA package insert doesn’t have numbers about how common side effects are.

More about Catapres side effects »
Risk factors for serious side effects
  • Diabetes
    • Coronary artery disease
    • Heart failure
    • Major surgery requiring anesthesia
    • History of asthma
    Detailed Toprol Xl (Metoprolol Succinate) risks & warnings »
    • Sudden discontinuation of medicine
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 years or older
    • Using other medicine(s) that slows the heart
    Detailed Catapres (Clonidine) risks & warnings »
    Pregnancy category
    No specific alcohol-related info.No specific alcohol-related info.
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
    • A first-choice treatment for heart failure. May prevent long-term heart damage.
    • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
    • Toprol XL is the extended release version of Lopressor.
    • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
    • Available in a weekly patch for people that aren't good at taking medicine by mouth.
    • Works in the brain, so it can help treat some nervous system and psychiatric conditions.
    • Under the brand name Kapvay, it's used to treat ADHD in children and teenagers.
    Downsides and risks
    • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
    • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
    • Can hide symptoms of low blood sugar if you're diabetic.
    • You can't miss doses. Stopping Toprol XL suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    • Has a lot of side effects compared to other blood pressure-lowering medicine because it works in the brain.
    • The pill form can make some people sleepy, dizzy, and have dry mouth.
    • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    Tips from our pharmacists for people taking the medication
    • Can cause dizziness in the first few days.
    • Can cause fatigue and headache.
    • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
    • Extended release version. Also comes in immediate release called Lopressor (metoprolol tartrate).
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Don't stop taking this medicine suddenly.
    • Usually taken together with other medicines for better blood pressure control.
    • Can cause drowsiness, headache, dizziness, and dry mouth.
    • If side effects don't go away, talk to your doctor about alternatives.
    • The weekly patch form can have fewer side effects.
    • Extended release tablet also used to treat ADHD.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Don't stop taking this medicine suddenly.
    Learn more
    More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
    More about CatapresSide effectsReviews & ratingsAlternativesFDA package insert