Compare Toprol XL vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Toprol Xl
(Metoprolol Succinate)

Microzide
(Hydrochlorothiazide )

Lowers blood pressure and controls heart rate. Toprol Xl (Metoprolol Succinate) is good for controlling chest pain and treating heart failure and heart attack. You can't miss doses.Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.2Toprol XL
Reviews for Toprol Xl (Metoprolol Succinate)
60%
of people (All ages) say Toprol Xl (Metoprolol Succinate) is worth it
54%
say it works well
13%
say it's a big hassle
164 reviews
Have you used Toprol Xl (Metoprolol Succinate)?
Worth itNot sureNot worth it
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
-13% worse vs. Toprol Xl (Metoprolol Succinate)
31%
-23% worse vs. Toprol Xl (Metoprolol Succinate)
16%
-3% worse vs. Toprol Xl (Metoprolol Succinate)
139 reviews
Have you used Microzide (Hydrochlorothiazide (Hctz))?
Worth itNot sureNot worth it
Side effects
Toprol XLHydrochlorothiazide
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Diarrhea 5%
  • Rash or pruritus 5%
  • Shortness of breath 3%
  • Abnormally slow heartbeat 3%
  • Low blood pressure 4%
  • Heart block 3%
More Toprol XL side effects »

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
How it works
Toprol XLHydrochlorothiazide
Toprol Xl (Metoprolol Succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.
Type of medication
Toprol XLHydrochlorothiazide
Prescription only
Prescription only
Available as
Toprol XLHydrochlorothiazide
  • Pill
  • Extended release
  • Pill
Used for
Toprol XLHydrochlorothiazide
Risk factors for serious side effects
Toprol XLHydrochlorothiazide
  • Diabetes
    • Coronary artery disease
    • Heart failure
    • Major surgery requiring anesthesia
    • History of asthma
    Detailed Toprol Xl (Metoprolol Succinate) risks & warnings »
    • Current electrolyte imbalance
    • History of sulfa allergies
    • History of gout
    • Current kidney problems
      Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Kidneys and liver
      Toprol XLHydrochlorothiazide
      No kidneys and liver related info.
      • Requires routine blood tests to check kidney function.
      Upsides and benefits
      Toprol XLHydrochlorothiazide
      • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
      • A first-choice treatment for heart failure. May prevent long-term heart damage.
      • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
      • Toprol XL is the extended release version of Lopressor.
      • Works well to get rid of extra fluids in your body through urination.
      • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
      • Lowers the risk of heart attack and stroke.
      • Good option if you have both high blood pressure and heart failure.
      • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
      • Most people have very few side effects.
      Downsides and risks
      Toprol XLHydrochlorothiazide
      • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
      • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
      • Can hide symptoms of low blood sugar if you're diabetic.
      • You can't miss doses. Stopping Toprol XL suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • Makes you urinate more often.
      • Doesn't work well in people with severe kidney problems.
      Tips from our pharmacists for people taking the medication
      Toprol XLHydrochlorothiazide
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Can cause fatigue and headache.
      • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
      • Don't stop taking this medicine suddenly.
      • Extended release version. Also comes in immediate release called Lopressor (metoprolol tartrate).
      • Starts working in about 2 hours.
      • Makes you urinate more often, so avoid taking it at bedtime.
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
      • Requires routine blood tests to check kidney function.
      Learn more
      More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Toprol Xl (Metoprolol Succinate)?
      Worth itNot sureNot worth it
      More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Microzide (Hydrochlorothiazide (Hctz))?
      Worth itNot sureNot worth it